scholarly journals Postoperative changes in plasma miR21‐5p as a novel biomarker for colorectal cancer recurrence: a prospective study

2021 ◽  
Author(s):  
Masahiro Fukada ◽  
Nobuhisa Matsuhashi ◽  
Takao Takahashi ◽  
Nobuhiko Sugito ◽  
Kazuki Heishima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prospective Study ◽  
Cancer Recurrence ◽  
Postoperative Changes ◽  
Colorectal Cancer Recurrence ◽  
A Prospective Study

scholarly journals The association between the adapted dietary inflammatory index and colorectal cancer recurrence and all-cause mortality

2021 ◽  
Author(s):  
Evertine Wesselink ◽  
Laura E. Staritsky ◽  
Moniek van Zutphen ◽  
Anne J.M.R. Geijsen ◽  
Dieuwertje E. Kok ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Recurrence ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
All Cause Mortality ◽  
Colorectal Cancer Recurrence

Prognostic Impact of Sarcopenia in Colorectal Cancer Recurrence

Nutrition ◽  
2021 ◽  
pp. 111362
Author(s):  
Koichi Takiguchi ◽  
Shinji Furuya ◽  
Makoto Sudo ◽  
Ryo Saito ◽  
Atsushi Yamamoto ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Recurrence ◽  
Prognostic Impact ◽  
Colorectal Cancer Recurrence

scholarly journals Baseline and Kinetic Circulating Tumor Cell Counts Are Prognostic Factors in a Prospective Study of Metastatic Colorectal Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 502
Author(s):  
Virgílio Souza e Silva ◽  
Emne Ali Abdallah ◽  
Angelo Borsarelli Carvalho de Brito ◽  
Alexcia Camila Braun ◽  
Milena Shizue Tariki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Prospective Study ◽  
Metastatic Colorectal Cancer ◽  
Clinical Outcomes ◽  
Predictive Biomarkers ◽  
Multi Drug Resistance ◽  
Cell Counts ◽  
Potential Clinical Benefit ◽  
A Prospective Study

The discovery of predictive biomarkers in metastatic colorectal cancer (mCRC) is essential to improve clinical outcomes. Recent data suggest a potential role of circulating tumor cells (CTCs) as prognostic indicators. We conducted a follow-on analysis from a prospective study of consecutive patients with mCRC. CTC analysis was conducted at two timepoints: baseline (CTC1; before starting chemotherapy), and two months after starting treatment (CTC2). CTC isolation/quantification were completed by ISET® (Rarecells, France). CTC expressions of drug resistance-associated proteins were evaluated. Progression-free survival (PFS) and overall survival (OS) were estimated by the Kaplan–Meier method. Seventy-five patients were enrolled from May 2012 to May 2014. A CTC1 cut-off of >1.5 CTCs/mL was associated with an inferior median OS compared to lower values. A difference of CTC2−CTC1 > 5.5 CTCs/mL was associated with a reduced median PFS. By multivariate analysis, CTC1 > 1.5 CTCs/mL was an independent prognostic factor for worse OS. Multi-drug resistance protein-1 (MRP-1) expression was associated with poor median OS. CTC baseline counts, kinetics, and MRP-1 expression were predictive of clinical outcomes. Larger studies are warranted to explore the potential clinical benefit of treating mCRC patients with targeted therapeutic regimens guided by CTC findings.

scholarly journals Tumor Tissue MIR92a and Plasma MIRs21 and 29a as Predictive Biomarkers Associated with Clinicopathological Features and Surgical Resection in a Prospective Study on Colorectal Cancer Patients

2020 ◽  
Vol 9 (8) ◽  
pp. 2509
Author(s):  
Masahiro Fukada ◽  
Nobuhisa Matsuhashi ◽  
Takao Takahashi ◽  
Nobuhiko Sugito ◽  
Kazuki Heishima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prospective Study ◽  
Surgical Resection ◽  
Tumor Tissue ◽  
Lymphatic Invasion ◽  
Clinicopathological Features ◽  
Stage Iii ◽  
Sample Type ◽  
Significant Difference ◽  
A Prospective Study

Cancer-related microRNAs (miRNAs) are emerging as non-invasive biomarkers for colorectal cancer (CRC). This study aimed to analyze the correlation between the levels of tissue and plasma miRNAs and clinicopathological characteristics and surgical resection. This study was a prospective study of CRC patients who underwent surgery. Forty-four sample pairs of tissue and plasma were analyzed. The miRNA levels were evaluated by RT-qPCR. The level of tumor tissue MIR92a showed a significant difference in CRC with lymph node metastasis, stage ≥ III, and high lymphatic invasion. In preoperative plasma, there were significant differences in CRC with stage ≥ III (MIR29a) and perineural invasion (MIR21). In multivariate analysis of lymphatic invasion, the levels of both preoperative plasma MIR29a and tumor tissue MIR92a showed significant differences. Furthermore, in cases with higher plasma miRNA level, the levels of plasma MIRs21 and 29a were significantly decreased after the operation. In this study, there were significant differences in miRNAs levels with respect to the sample type, clinicopathological features, and surgical resection. The levels of tumor tissue MIR92a and preoperative plasma MIR29a may have the potential as a biomarker for prognosis. The plasma MIRs21 and 29a level has the potential to be a predictive biomarker for treatment efficacy.

scholarly journals A Prospective Study of Plasma C-Peptide and Colorectal Cancer Risk in Men

2004 ◽  
Vol 96 (7) ◽  
pp. 546-553 ◽  
Author(s):  
J. Ma ◽  
E. Giovannucci ◽  
M. Pollak ◽  
A. Leavitt ◽  
Y. Tao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Prospective Study ◽  
Colorectal Cancer Risk ◽  
C Peptide ◽  
A Prospective Study

Local colorectal cancer recurrence: pelvic MRI evaluation

2012 ◽  
Vol 38 (1) ◽  
pp. 72-81 ◽  
Author(s):  
A. Colosio ◽  
P. Fornès ◽  
P. Soyer ◽  
M. Lewin ◽  
M. Loock ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Recurrence ◽  
Pelvic Mri ◽  
Colorectal Cancer Recurrence ◽  
Mri Evaluation

Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis

2014 ◽  
Vol 25 (10) ◽  
pp. 1407-1418 ◽  
Author(s):  
Sabrina Schlesinger ◽  
Sabine Siegert ◽  
Manja Koch ◽  
Jessica Walter ◽  
Nils Heits ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Prospective Study ◽  
Cancer Survivors ◽  
Body Mass ◽  
Meta Analysis ◽  
Colorectal Cancer Survivors ◽  
Risk Of Mortality ◽  
A Prospective Study
Sign in / Sign up

Export Citation Format

Share Document