scholarly journals Short‐term cultured autologous PBMCs as a potential immunogen to activate Tax‐specific CTL response in adult T‐cell leukemia patients

2021 ◽  
Author(s):  
Miku Ishizawa ◽  
Undrakh Ganbaatar ◽  
Atsuhiko Hasegawa ◽  
Natsuko Takatsuka ◽  
Nobuyo Kondo ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Short Term ◽  
Ctl Response ◽  
Adult T Cell Leukemia

scholarly journals Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

Blood ◽  
1986 ◽  
Vol 68 (3) ◽  
pp. 779-782 ◽  
Author(s):  
N Arima ◽  
Y Daitoku ◽  
S Ohgaki ◽  
J Fukumori ◽  
H Tanaka ◽  
...  
Keyword(s):  
T Cell ◽  
Interleukin 2 ◽  
Leukemic Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Autocrine Growth ◽  
Short Term ◽  
Adult T Cell Leukemia ◽  
Spontaneous Proliferation ◽  
Short Term Culture

Abstract Leukemic cells in the peripheral blood of a patient with adult T cell leukemia (ATL), which expressed the Tac antigen/interleukin 2 (IL2) receptor, were investigated in vitro for autocrine growth by IL 2. The cells showed spontaneous proliferation in mitogen-free medium. The spontaneous proliferation of the cells was inhibited by monoclonal anti- IL 2 or anti-Tac antibody. These cells were found to produce messenger RNA for IL 2 and secrete IL 2 during short-term culture in the same medium. Recombinant IL 2 and IL 2 secreted by the cells enhanced the proliferation of the cells in a dose-dependent manner when added to the initial culture. These findings demonstrate that an autocrine mechanism by IL 2 is involved in the proliferation of ATL cells during short-term culture.

scholarly journals Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia

2010 ◽  
Vol 207 (13) ◽  
pp. 2785-2792 ◽  
Author(s):  
Hiba El Hajj ◽  
Marwan El-Sabban ◽  
Hideki Hasegawa ◽  
Ghazi Zaatari ◽  
Julien Ablain ◽  
...  
Keyword(s):  
T Cell ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Short Term ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Long Term Prognosis ◽  
Cell Immortality

Chronic HTLV-I (human T cell lymphotropic virus type I) infection may cause adult T cell leukemia/lymphoma (ATL), a disease with dismal long-term prognosis. The HTLV-I transactivator, Tax, initiates ATL in transgenic mice. In this study, we demonstrate that an As2O3 and IFN-α combination, known to trigger Tax proteolysis, cures Tax-driven ATL in mice. Unexpectedly, this combination therapy abrogated initial leukemia engraftment into secondary recipients, whereas the primary tumor bulk still grew in the primary hosts, only to ultimately abate later on. This loss of initial transplantability required proteasome function. A similar regimen recently yielded unprecedented disease control in human ATL. Our demonstration that this drug combination targeting Tax stability abrogates tumor cell immortality but not short-term growth may foretell a favorable long-term efficiency of this regimen in patients.

scholarly journals Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

Blood ◽  
1986 ◽  
Vol 68 (3) ◽  
pp. 779-782 ◽  
Author(s):  
N Arima ◽  
Y Daitoku ◽  
S Ohgaki ◽  
J Fukumori ◽  
H Tanaka ◽  
...  
Keyword(s):  
T Cell ◽  
Interleukin 2 ◽  
Leukemic Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Autocrine Growth ◽  
Short Term ◽  
Adult T Cell Leukemia ◽  
Spontaneous Proliferation ◽  
Short Term Culture

Leukemic cells in the peripheral blood of a patient with adult T cell leukemia (ATL), which expressed the Tac antigen/interleukin 2 (IL2) receptor, were investigated in vitro for autocrine growth by IL 2. The cells showed spontaneous proliferation in mitogen-free medium. The spontaneous proliferation of the cells was inhibited by monoclonal anti- IL 2 or anti-Tac antibody. These cells were found to produce messenger RNA for IL 2 and secrete IL 2 during short-term culture in the same medium. Recombinant IL 2 and IL 2 secreted by the cells enhanced the proliferation of the cells in a dose-dependent manner when added to the initial culture. These findings demonstrate that an autocrine mechanism by IL 2 is involved in the proliferation of ATL cells during short-term culture.

Differences Between Long- and Short-Term Survivors with Lymphoma Type of Adult T-Cell Leukemia

1990 ◽  
Vol 2 (5) ◽  
pp. 301-305 ◽  
Author(s):  
Yoshinori Shimamot ◽  
Kenji Suga ◽  
Hideya Igarashi ◽  
Junji Nishimura ◽  
Hajime Nawata ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Short Term ◽  
Adult T Cell Leukemia ◽  
Lymphoma Type

Three Cases of Adult T Cell Leukemia

1980 ◽  
Vol 42 (5) ◽  
pp. 802-810 ◽  
Author(s):  
Kenji SUGIMOTO ◽  
Yoko NAKANO ◽  
Masayuki SHIMIZU ◽  
Yasuo NAKAMURA ◽  
Kota TSUJI
Keyword(s):  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia
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