Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats

The article studies features of socio-economic and socio-political development of the Black Sea village in 1920s. Documents from the fond of the Black Sea District Committee (Obkom) of the RCP (b) -VKP (b) stored in the Center for Documentation of the Modern History of the Krasnodar Krai allow not only to reconstruct the developments in the Black Sea village in the NEP days, but also to understand the nature of its evolution. Uniqueness of the Black Sea village was greatly determined by its geographical environment. There had formed a sectoral makeup of agricultural production: fruit-farming, viticulture, tobacco growing. Rugged relief forced peasants to form holdings or farms; therefore rural communities were rare. Its another distinctive feature was its motley national composition. Over 50 ethnic groups inhabited the district, among most numerous were the Russians, the Ukrainians, the Armenians, and the Greeks. In the first years of the NEP, the main tasks facing district authorities were to develop ‘high-intensity’ industries and to shape local peasant farms into food base for cities and resorts. While tackling these tasks, they had to deal with shortages of land and poor communications and to bring lease relations and work-hands employment up to scratch. The situation was complicated by socio-political inertia of rural population of the district that came from the absence of community tradition. Study of the documents from the fond of the Black Sea party obkom shows that local authorities were well aware of the peculiarity of their region, but in most cases had to follow guidelines set ‘from above’ to introduce all-Russian standards.

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الجامعة الاسلامية العالمية بماليزيا وودورها فى تعليم اللغة العربية للناطقين بغيرها International Islamic University of Malaysia and Its Role in Teaching Arabic to Non-Native Speakers

Journal of Islam in Asia <span style="font-size: 0.6em">(E-ISSN: 2289-8077)</span> ◽

10.31436/jia.v10i2.396 ◽

2014 ◽

Vol 10 (2) ◽

pp. 66

Author(s):

علاء حسنى المزين (Alaa Hosni)

Keyword(s):

Distinctive Feature ◽

Native Speakers ◽

Arabic Language ◽

Strong Connection ◽

Positive Effects ◽

The World ◽

Islamic Identity ◽

Islamic Civilization ◽

The University ◽

Scientific Documentation

كان من أهم الآثار الإيجابية للصحوة الإسلامية التى عمت العالم الإسلامى بشكل ملحوظ منذ أوائل السبعينيات فى القرن العشرين زيادة إقبال الشعوب الإسلامية على تعلم اللغة العربية، وبدأ الاهتمام الحقيقى لجامعات العالم الإسلامى بتوفير مساقات متخصصة لهذا الغرض منذ أوائل الثمانينات، وكانت الجامعة الإسلامية العالمية بماليزيا التى أسست سنة 1983 من أنشط الجامعات فى هذا الصدد، وهو نشاط استلفت نظر الباحث إذ وجده يستحق الرصد والتوثيق العلمى، والمراجعة إذا اقتضت الضرورة لا بهدف الإشادة بالتجربة بل رغبة فى الإفادة والاستفادة من قبل المختصين من المهتمين بهذا الميدان الحيوى من ميادين خدمة اللغة العربية بل خدمة الإسلام، وحضارته نظرا للارتباط الوثيق بين اللغة العربية وهذا الدين الحنيف باعتبارها لغة كتابه الخالد، والمعلم الرئيس من معالم الهوية الإسلامية المميزة والصمود الحضارى.*****************************************************One of the most positive effects of the Islamic awakening since the early seventies, in the twentieth century, which spread across the Islamic world in a significant manner, has been the increased Muslims’ interest in learning the Arabic language all over the world. There began a real interest in the universities of the Muslim world for the Arabic language by providing specialized courses for this purpose since the early eighties and the International Islamic University Malaysia established in 1983 has been the most active university in this regard. And this activity of the university drew the interest of the researcher who found it worthy of investigation and scientific documentation as well as of revision, if necessary, not in order to pay tribute to the experience, but for taking advantage and learning from specialists interested in this vital field of the fields of Arabic language service which is actually service of Islam and its civilization considering the strong connection between Islam and the Arabic language, the language of the Qur’Én , the most distinctive feature of Islamic identity and resilience of Islamic civilization.

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Kant’s Contradiction in Conception Test

Theoria ◽

10.3167/th.2017.6415201 ◽

2017 ◽

Vol 64 (152) ◽

pp. 1-23

Author(s):

James Furner

Keyword(s):

Distinctive Feature ◽

Law Of Nature ◽

Logical Contradiction ◽

Hybrid View ◽

The Law ◽

New Interpretation ◽

Universal Law

AbstractThe contradiction in conception test (CC test) is one of two tests posed by Kant’s Formula of the Law of Nature. This article proposes a new interpretation of this test: a causal-teleological version of the Logical Contradiction Interpretation (LCI). Its distinctive feature is that it identifies causal and teleological implications in the thought of a universal law of nature. A causal-teleological version of LCI has two advantages. While the established view of the Groundwork’s applications of the CC test is a hybrid view that treats the Groundwork’s arguments as different in kind, a causal-teleological version of LCI unifies the Groundwork’s applications of the CC test. Relatedly, a causal-teleological version of LCI provides a solution to the problem of how the CC test can confirm the impermissibility of a self-directed maxim.

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Synthezis the strucrure of cloud computing system to control of mobile robots group

Proceedings of the Mavlyutov Institute of Mechanics ◽

10.21662/uim2016.1.011 ◽

2016 ◽

Vol 11 (1) ◽

pp. 72-80

Author(s):

O.V. Darintsev ◽

A.B. Migranov

Keyword(s):

Cloud Computing ◽

Mobile Robots ◽

Distinctive Feature ◽

Information Exchange ◽

High Performance ◽

Computing System ◽

Control Information ◽

Cloud Computing System ◽

Group Control ◽

Reliability And Robustness

In article one of possible approaches to synthezis of group control of mobile robots which is based on use of cloud computing is considered. Distinctive feature of the offered techniques is adequate reflection of specifics of a scope and the robots of tasks solved by group in architecture of control-information systems, methods of the organization of information exchange, etc. The approach offered by authors allows to increase reliability and robustness of collectives of robots, to lower requirements to airborne computers when saving summary high performance in general.

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Italy

10.1093/oso/9780198779599.003.0004 ◽

2018 ◽

Author(s):

Maurizio Ferrera

Keyword(s):

Social Policy ◽

Welfare State ◽

Distinctive Feature ◽

Social Insurance ◽

State Compensation ◽

Early Colonial ◽

Comprehensive Reform ◽

Veteran Benefits ◽

Democratic Stability ◽

War Mobilization

Wars have had a clearly recognizable impact on Italy’s social policy since unification. The independence and early colonial wars prompted the introduction of veteran benefits and other forms of state compensation. The two world wars marked key turning points, creating the conditions for introducing compulsory social insurance and then extending its scope and coverage. The pronatalist policies introduced by Fascism were in their turn closely linked to the regime’s war mobilization strategy. In comparative perspective, a distinctive feature of Italian developments was the elaboration of very ambitious and comprehensive reform plans after both world wars, largely motivated by the wish to forge broad cross-class coalitions and safeguard democratic stability. Even if initially unsuccessful, such plans left an ideational legacy which contributed to inspire welfare state developments well throughout the so-called Golden Age.

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Background Practices

10.1093/oso/9780198796220.001.0001 ◽

2017 ◽

Cited By ~ 7

Author(s):

Hubert L. Dreyfus

Keyword(s):

Scientific Realism ◽

Distinctive Feature ◽

Phenomenological Description ◽

Existential Philosophy ◽

Textual Exegesis ◽

European Tradition ◽

Continental Divide ◽

European Philosophy ◽

Anglophone World ◽

Hubert Dreyfus

Hubert Dreyfus is one of the foremost advocates of European philosophy in the anglophone world. His clear, jargon-free interpretations of the leading thinkers of the European tradition of philosophy have done a great deal to erase the analytic–Continental divide. But Dreyfus is not just an influential interpreter of Continental philosophers; he is a creative, iconoclastic thinker in his own right. Drawing on the work of Heidegger, Husserl, Merleau-Ponty, Foucault, and Kierkegaard, Dreyfus makes significant contributions to contemporary conversations about mind, authenticity, technology, nihilism, modernity and postmodernity, art, scientific realism, and religion. This volume collects thirteen of Dreyfus’s most influential essays, each of which interprets, develops, and extends the insights of his predecessors working in phenomenological and existential philosophy. The essays exemplify a distinctive feature of his approach to philosophy, namely the way his work inextricably intertwines the interpretation of texts with his own analysis and description of the phenomena at issue. In fact, these two tasks—textual exegesis and phenomenological description—are for Dreyfus necessarily dependent on each other. In approaching philosophy in this way, Dreyfus is an heir to Heidegger’s own historically oriented style of phenomenology.

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Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

Communications Biology ◽

10.1038/s42003-021-02430-5 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Meilin Chan ◽

Licun Wu ◽

Zhihong Yun ◽

Trevor D. McKee ◽

Michael Cabanero ◽

...

Keyword(s):

Tumor Growth ◽

Malignant Pleural Mesothelioma ◽

Neutralizing Antibodies ◽

Pleural Mesothelioma ◽

Spheroid Formation ◽

Resistance To Therapy ◽

Sarcomatoid Mesothelioma

AbstractMalignant pleural mesothelioma (MPM) is an aggressive neoplasm originating from the pleura. Non-epithelioid (biphasic and sarcomatoid) MPM are particularly resistant to therapy. We investigated the role of the GITR-GITRL pathway in mediating the resistance to therapy. We found that GITR and GITRL expressions were higher in the sarcomatoid cell line (CRL5946) than in non-sarcomatoid cell lines (CRL5915 and CRL5820), and that cisplatin and Cs-137 irradiation increased GITR and GITRL expressions on tumor cells. Transcriptome analysis demonstrated that the GITR-GITRL pathway was promoting tumor growth and inhibiting cell apoptosis. Furthermore, GITR+ and GITRL+ cells demonstrated increased spheroid formation in vitro and in vivo. Using patient derived xenografts (PDXs), we demonstrated that anti-GITR neutralizing antibodies attenuated tumor growth in sarcomatoid PDX mice. Tumor immunostaining demonstrated higher levels of GITR and GITRL expressions in non-epithelioid compared to epithelioid tumors. Among 73 patients uniformly treated with accelerated radiation therapy followed by surgery, the intensity of GITR expression after radiation negatively correlated with survival in non-epithelioid MPM patients. In conclusion, the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma, associated with tumor stemness and resistance to therapy. Blocking the GITR-GITRL pathway could be a new therapeutic target for non-epithelioid mesothelioma.

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25-Gauge Catheter as a Surrogate to Anterior Chamber Maintainer in Trabeculectomy

Surgical Innovation ◽

10.1177/1553350620982182 ◽

2021 ◽

pp. 155335062098218

Author(s):

Alessandra A. Kusabara ◽

Niro Kasahara

Keyword(s):

Surgical Technique ◽

Anterior Chamber ◽

Distinctive Feature ◽

Low Cost ◽

Economic Environment ◽

Intravenous Catheter ◽

Flat Anterior Chamber ◽

Limited Health

A flat anterior chamber (AC) is a distinctive feature in status post vitrectomy eyes during trabeculectomy. The use of AC maintainers is useful to help prevent this peroperative situation. We herein describe the surgical technique using a 25-gauge intravenous catheter as a surrogate to conventional AC maintainers. A potential advantage of this approach is the low cost in the current economic environment with limited health restraints.

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Digital Gene Expression Analysis of Epithelioid and Sarcomatoid Mesothelioma Reveals Differences in Immunogenicity

Cancers ◽

10.3390/cancers13081761 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1761

Author(s):

Luka Brcic ◽

Alexander Mathilakathu ◽

Robert F. H. Walter ◽

Michael Wessolly ◽

Elena Mairinger ◽

...

Keyword(s):

Gene Expression ◽

Antigen Processing ◽

Checkpoint Inhibitors ◽

Cytotoxic T Cells ◽

Asbestos Exposure ◽

Gene Expression Pattern ◽

Digital Gene Expression ◽

Cell Interaction ◽

Time To Death ◽

Sarcomatoid Mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive malignancy associated with asbestos exposure. Median survival ranges from 14 to 20 months after initial diagnosis. As of November 2020, the FDA approved a combination of immune checkpoint inhibitors after promising intermediate results. Nonetheless, responses remain unsatisfying. Adequate patient stratification to improve response rates is still lacking. This retrospective study analyzed formalin fixed paraffin embedded specimens from a cohort of 22 MPM. Twelve of those samples showed sarcomatoid, ten epithelioid differentiation. Complete follow-up, including radiological assessment of response by modRECIST and time to death, was available with reported deaths of all patients. RNA of all samples was isolated and subjected to digital gene expression pattern analysis. Our study revealed a notable difference between epithelioid and sarcomatoid mesothelioma, showing differential gene expression for 304/698 expressed genes. Whereas antigen processing and presentation to resident cytotoxic T cells as well as phagocytosis is highly affected in sarcomatoid mesothelioma, cell–cell interaction via cytokines seems to be of greater importance in epithelioid cases. Our work reveals the specific role of the immune system within the different histologic subtypes of MPM, providing a more detailed background of their immunogenic potential. This is of great interest regarding therapeutic strategies including immunotherapy in mesothelioma.

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