scholarly journals Bone invasion‐targeted chemotherapy with a novel anionic platinum complex (3Pt) for oral squamous cell carcinoma

2019 ◽  
Vol 110 (10) ◽  
pp. 3288-3295 ◽  
Author(s):  
Yoshiya Kasahara ◽  
Kazuhira Endo ◽  
Takayoshi Ueno ◽  
Haruna Ueno ◽  
Makiko Moriyama‐Kita ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Platinum Complex ◽  
Targeted Chemotherapy ◽  
Bone Invasion

Bone invasion by oral squamous cell carcinoma

2021 ◽  
Vol 63 (3) ◽  
Author(s):  
David Král ◽  
Richard Pink ◽  
Lenka Šašková ◽  
Jaroslav Michálek ◽  
Peter Tvrdý
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Invasion

scholarly journals CCL28-induced RARβ expression inhibits oral squamous cell carcinoma bone invasion

2019 ◽  
Vol 129 (12) ◽  
pp. 5381-5399 ◽  
Author(s):  
Junhee Park ◽  
Xianglan Zhang ◽  
Sun Kyoung Lee ◽  
Na-Young Song ◽  
Seung Hwa Son ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Invasion

scholarly journals Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma

2013 ◽  
Vol 104 (3) ◽  
pp. 369-374 ◽  
Author(s):  
Kazuhira Endo ◽  
Takayoshi Ueno ◽  
Satoru Kondo ◽  
Naohiro Wakisaka ◽  
Shigeyuki Murono ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Targeted Chemotherapy

Tumor-Targeted Chemotherapy: Role in Oral Squamous Cell Carcinoma (OSCC) Management

2014 ◽  
Vol 72 (9) ◽  
pp. e38-e39
Author(s):  
M.B. Border ◽  
A. Holpuch ◽  
B. Han ◽  
G. Koutras ◽  
M. Tong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Targeted Chemotherapy

scholarly journals The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yin-Zhe An ◽  
Eunae Cho ◽  
Junqi Ling ◽  
Xianglan Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Associated Fibroblasts ◽  
Bone Invasion ◽  
Biological Behaviour ◽  
Snail Expression

Abstract Background In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. Methods The clinicopathological significance of Axin2 and Snail expression was investigated by immunohistochemistry in an OSCC cohort containing 217 tissue samples from patients with long-term follow-up. The influence of the Axin2-Snail axis on the biological behaviour of OSCC cells and CAFs was further investigated both in vitro and in vivo. Results Axin2 expression was significantly associated with Snail expression, the desmoplasia status, and bone invasion in patients with OSCC. In multivariate analysis, lymph node metastasis, desmoplasia, Axin2 expression, and Snail expression were independent poor prognostic factors in our cohort. Consistent with these findings, OSCC cells demonstrated attenuated oncogenic activity as well as decreased expression of Snail and various cytokines after Axin2 knockdown in vitro. Among the related cytokines, C-C motif chemokine ligand 5 (CCL5) and interleukin 8 (IL8) demonstrated a strong influence on the biological behaviour of CAFs in vitro. Moreover, both the desmoplastic reaction and osteolytic lesions in the calvaria were predominantly decreased after Axin2 knockdown in OSCC cells in vivo using a BALB/c athymic nude mouse xenograft model. Conclusions Oncogenic activities of the Axin2-Snail axis are not limited to the cancer cells themselves but rather extend to CAFs via regulation of the cytokine-mediated cancer-stromal interaction, with further implications for bone invasion as well as a poor prognosis in OSCC.

scholarly journals Establishment of a murine model of bone invasion by oral squamous cell carcinoma

Oral Oncology ◽  
2007 ◽  
Vol 43 (3) ◽  
pp. 257-262 ◽  
Author(s):  
Takeshi Nomura ◽  
Takahiko Shibahara ◽  
Akira Katakura ◽  
Shizuka Matsubara ◽  
Nobuo Takano
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Murine Model ◽  
Bone Invasion
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