scholarly journals A group of long noncoding RNAs identified by data mining can predict the prognosis of lung adenocarcinoma

2018 ◽  
Vol 109 (12) ◽  
pp. 4033-4044 ◽  
Author(s):  
Meijian Liao ◽  
Qing Liu ◽  
Bing Li ◽  
Weijie Liao ◽  
Weidong Xie ◽  
...  
Keyword(s):  
Data Mining ◽  
Lung Adenocarcinoma ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Lijuan Hu ◽  
Jian Chen ◽  
Fan Zhang ◽  
Junjun Wang ◽  
Jingye Pan ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
A549 Cell ◽  
Cisplatin Resistance ◽  
Expression Profiles ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Pcr Analysis ◽  
Sensitive Cell ◽  
Chain Reaction ◽  
Polymerase Chain

Background. Long noncoding RNAs (lncRNAs) have been shown to be involved in the mechanism of cisplatin resistance in lung adenocarcinoma (LAD). However, the roles of lncRNAs in cisplatin resistance in LAD are not well understood. Methods. We used a high-throughput microarray to compare the lncRNA and mRNA expression profiles in cisplatin resistance cell A549/DDP and cisplatin sensitive cell A549. Several candidate cisplatin resistance-associated lncRNAs were verified by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis. Results. We found that 1,543 lncRNAs and 1,713 mRNAs were differentially expressed in A549/DDP cell and A549 cell, hinting that many lncRNAs were irregular from cisplatin resistance in LAD. We also obtain the fact that 12 lncRNAs were aberrantly expressed in A549/DDP cell compared with A549 cell by quantitative PCR. Among these, UCA1 was the aberrantly expressed lncRNA and can significantly reduce the IC50 of cisplatin in A549/DDP cell after knockdown, while it can increase the IC50 of cisplatin after UCA1 was overexpressed in NCI-H1299. Conclusions. We obtained patterns of irregular lncRNAs and they may play a key role in cisplatin resistance of LAD.

scholarly journals Expression profiles of long noncoding RNAs in lung adenocarcinoma

2018 ◽  
Vol Volume 11 ◽  
pp. 5383-5390 ◽  
Author(s):  
Bing Zhao ◽  
Hang Xu ◽  
Xiaoye Ai ◽  
Yasheng Adalat ◽  
Ying Tong ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Expression Profiles ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Genomic data mining for functional annotation of human long noncoding RNAs

2019 ◽  
Vol 20 (6) ◽  
pp. 476-487 ◽  
Author(s):  
Brian L. Gudenas ◽  
Jun Wang ◽  
Shu-zhen Kuang ◽  
An-qi Wei ◽  
Steven B. Cogill ◽  
...  
Keyword(s):  
Data Mining ◽  
Functional Annotation ◽  
Noncoding Rnas ◽  
Genomic Data ◽  
Long Noncoding Rnas ◽  
Genomic Data Mining

Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long noncoding RNAs

Lung Cancer ◽  
2015 ◽  
Vol 88 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Ping Wang ◽  
Shaohua Lu ◽  
Hailei Mao ◽  
Yanan Bai ◽  
Tianle Ma ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Early Stage ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Microarray Profiling
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