scholarly journals PIK 3 CA mutation profiling in patients with breast cancer, using a highly sensitive detection system

2018 ◽  
Vol 109 (8) ◽  
pp. 2558-2566 ◽  
Author(s):  
Tatsunori Shimoi ◽  
Akinobu Hamada ◽  
Marifu Yamagishi ◽  
Mitsuharu Hirai ◽  
Masayuki Yoshida ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Detection System ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Mutation Profiling

scholarly journals Highly Sensitive Detection of HER2 Extracellular Domain in the Serum of Breast Cancer Patients by Piezoelectric Microcantilevers

2011 ◽  
Vol 83 (9) ◽  
pp. 3392-3397 ◽  
Author(s):  
LiNa Loo ◽  
Joseph A. Capobianco ◽  
Wei Wu ◽  
Xiaotong Gao ◽  
Wan Y. Shih ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Extracellular Domain ◽  
Sensitive Detection ◽  
Breast Cancer Patients ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

scholarly journals Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients

2003 ◽  
Vol 108 (4) ◽  
pp. 592-595 ◽  
Author(s):  
Nuno Cerveira ◽  
Lurdes Torres ◽  
Patr�cia Rocha ◽  
Susana Bizarro ◽  
Deolinda Pereira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Sensitive Detection ◽  
Breast Cancer Patients ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

A new highly sensitive detection system for peptides and proteins in column effluents

1972 ◽  
Vol 66 (1) ◽  
pp. 145-152 ◽  
Author(s):  
J.J.T. Gerding ◽  
H.J.M. Kempe ◽  
B.J.M. Lamer ◽  
M.H. Gerdin
Keyword(s):  
Detection System ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

scholarly journals Aptamer Embedded Arch-Cruciform DNA Assemblies on 2-D VS2 Scaffolds for Sensitive Detection of Breast Cancer Cells

Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 378
Author(s):  
Jinfeng Quan ◽  
Yihan Wang ◽  
Jialei Zhang ◽  
Kejing Huang ◽  
Xuemei Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Dna Sequences ◽  
Breast Cancer Cells ◽  
Limit Of Detection ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Cruciform Dna ◽  
Mcf 7

Arch-cruciform DNA are self-assembled on AuNPs/VS2 scaffold as a highly sensitive and selective electrochemical biosensor for michigan cancer foundation-7 (MCF-7) breast cancer cells. In the construction, arch DNA is formed using two single-strand DNA sequences embedded with the aptamer for MCF-7 cells. In the absence of MCF-7 cells, a cruciform DNA labeled with three terminal biotin is bound to the top of arch DNA, which further combines with streptavidin-labeled horseradish peroxidase (HRP) to catalyze the hydroquinone-H2O2 reaction on the electrode surface. The presence of MCF-7 cells can release the cruciform DNA and reduce the amount of immobilized HRP, thus effectively inhibiting enzyme-mediated electrocatalysis. The electrochemical response of the sensor is negatively correlated with the concentration of MCF-7 cells, with a linear range of 10 − 1 × 105 cells/mL, and a limit of detection as low as 5 cells/mL (S/N = 3). Through two-dimensional materials and enzyme-based dual signal amplification, this biosensor may pave new ways for the highly sensitive detection of tumor cells in real samples.

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