scholarly journals Metabolome analysis for pancreatic cancer risk in nested case-control study: Japan Public Health Center-based prospective Study

2018 ◽  
Vol 109 (5) ◽  
pp. 1672-1681 ◽  
Author(s):  
Takashi Nakagawa ◽  
Takashi Kobayashi ◽  
Shin Nishiumi ◽  
Akihisa Hidaka ◽  
Taiki Yamaji ◽  
...  
Keyword(s):  
Public Health ◽  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Prospective Study ◽  
Health Center ◽  
Case Control Study ◽  
Case Control ◽  
Metabolome Analysis ◽  
Nested Case Control ◽  
Control Study

Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study

2007 ◽  
Vol 19 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Tetsuya Otani ◽  
Motoki Iwasaki ◽  
Shizuka Sasazuki ◽  
Manami Inoue ◽  
Shoichiro Tsugane ◽  
...  
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Prospective Study ◽  
Health Center ◽  
Case Control Study ◽  
Case Control ◽  
Public Health Center ◽  
Plasma Folate ◽  
Nested Case Control ◽  
Control Study

Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: A Nested Case-Control Study From the Japan Public Health Center-Based Prospective Study Group

2008 ◽  
Vol 26 (10) ◽  
pp. 1677-1683 ◽  
Author(s):  
Motoki Iwasaki ◽  
Manami Inoue ◽  
Tetsuya Otani ◽  
Shizuka Sasazuki ◽  
Norie Kurahashi ◽  
...  
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Plasma Level ◽  
Prospective Study ◽  
Health Center ◽  
Case Control Study ◽  
Case Control ◽  
Inverse Association ◽  
Nested Case Control ◽  
Control Study

Purpose Because they have large variations in consumption, Asian countries are suitable settings for studies of the effect of relatively high-dose isoflavone intake on breast cancer risk. Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake. Patients and Methods A total of 24,226 women ages 40 to 69 years in the Japan Public Health Center–based prospective study who responded to the baseline questionnaire and provided blood in 1990 to 1995 were observed to December 2002. During a mean 10.6 years of follow-up, 144 patients newly diagnosed with breast cancer were identified. Two matched controls for each patient were selected from the cohort. Isoflavone levels were assessed by plasma level and food frequency questionnaire, and the odds ratio of breast cancer according to isoflavone level was estimated using a conditional logistic regression model. Results We found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups. Regarding dietary intake of isoflavones, nonsignificant inverse associations were observed for both genistein and daidzein. Conclusion This nested case-control study found an inverse association between plasma genistein and the risk of breast cancer in Japan.

scholarly journals A Prospective Nested Case-Control Study of Vitamin D Status and Pancreatic Cancer Risk in Male Smokers

2006 ◽  
Vol 66 (20) ◽  
pp. 10213-10219 ◽  
Author(s):  
Rachael Z. Stolzenberg-Solomon ◽  
Reinhold Vieth ◽  
Azar Azad ◽  
Pirjo Pietinen ◽  
Philip R. Taylor ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Status ◽  
Pancreatic Cancer Risk ◽  
Nested Case Control ◽  
Control Study

Plasma Isoflavones and Subsequent Risk of Prostate Cancer in a Nested Case-Control Study: The Japan Public Health Center

2008 ◽  
Vol 26 (36) ◽  
pp. 5923-5929 ◽  
Author(s):  
Norie Kurahashi ◽  
Motoki Iwasaki ◽  
Manami Inoue ◽  
Shizuka Sasazuki ◽  
Shoichiro Tsugane
Keyword(s):  
Public Health ◽  
Prostate Cancer ◽  
Health Center ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Conditional Logistic Regression Model ◽  
Public Health Center ◽  
Nested Case Control ◽  
Control Study

PurposeThe incidence of prostate cancer is much lower in Japanese than Western populations. Given the preventive effects of isoflavones on carcinogenesis in the prostate in many nonhuman studies and the high consumption of isoflavones in Japanese, this low incidence may be partly due to the effects of soy.Patients and MethodsWe conducted a nested case-control study within the Japan Public Health Center–based Prospective Study. A total of 14,203 men aged 40 to 69 years who had returned the baseline questionnaire and provided blood samples were observed from 1990 to 2005. During a mean of 12.8 years of follow-up, 201 newly diagnosed prostate cancers were identified. Two matched controls for each case were selected from the cohort. Conditional logistic regression model was used to estimate the odds ratios (ORs) and 95% CIs for prostate cancer in relation to plasma levels of isoflavone.ResultsPlasma genistein level tended to be inversely associated with the risk of total prostate cancer. Although plasma daidzein showed no association, the highest tertile for plasma equol, a metabolite of daidzein, was significantly associated with a decreased risk of total prostate cancer (OR = 0.60; 95% CI, 0.36 to 0.99; Ptrend= .04). These inverse associations were strengthened after analysis was confined to localized cases, with ORs in the highest group of plasma genistein and equol compared with the lowest of 0.54 (95% CI, 0.29 to 1.01; Ptrend= .03) and 0.43 (95% CI, 0.22 to 0.82; Ptrend= .02), respectively. Plasma isoflavone levels were not statistically significantly associated with the risk of advanced prostate cancer.ConclusionIsoflavones may prevent the development of prostate cancer.

Statins and pancreatic cancer risk: a nested case–control study

2010 ◽  
Vol 21 (12) ◽  
pp. 2093-2100 ◽  
Author(s):  
Marie C. Bradley ◽  
Carmel M. Hughes ◽  
Marie M. Cantwell ◽  
Liam J. Murray
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Pancreatic Cancer Risk ◽  
Nested Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document