scholarly journals Prognostic value of serum Epstein–Barr virus antibodies in patients with nasopharyngeal carcinoma and undetectable pretreatment Epstein–Barr virus DNA

2017 ◽  
Vol 108 (8) ◽  
pp. 1640-1647 ◽  
Author(s):  
Ji‐Jin Yao ◽  
Li Lin ◽  
Ya‐Nan Jin ◽  
Si‐Yang Wang ◽  
Wang‐Jian Zhang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Prognostic value of Epstein-Barr virus serology in patients with nasopharyngeal carcinoma

1993 ◽  
Vol 26 (2) ◽  
pp. 171-175 ◽  
Author(s):  
D.E. Wyatt ◽  
D.S. Brooker ◽  
J.H. Connolly ◽  
P.V. Coyle
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Prognostic Value of Plasma Epstein-Barr Virus DNA Levels Pre- and Post-Neoadjuvant Chemotherapy in Patients With Nasopharyngeal Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Lisheng Zhu ◽  
Tao Ouyang ◽  
Ying Xiong ◽  
Li Ba ◽  
Qiuting Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Progression Free Survival ◽  
Post Treatment ◽  
Rank Test ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

BackgroundIn this study, we evaluated the prognostic value of the plasma levels of Epstein-Barr virus (EBV) DNA in patients with nasopharyngeal carcinoma (NPC) at different treatment stages.MethodsWe retrospectively analyzed the Data of 206 patients with NPC. Pre-neoadjuvant chemotherapy (pre-NACT), post-NACT, post-radiotherapy, and post-treatment plasma EBV DNA levels were used to establish prognostic nomograms. The concordance index (C-index) and calibration curves were used to compare the prognostic accuracy of the nomograms. The results were confirmed in a validation cohort consisting of patients who were tested for EBV DNA levels at all four stages of treatment. The Kaplan-Meier method was used to calculate the progression-free survival (PFS) and overall survival (OS). Survival differences were calculated using the log-rank test.ResultsEBV DNA-positive patients had worse 3-year PFS and 5-year OS than EBV DNA-negative patients; this was true for pre-NACT (PFS: 82.7% vs. 57.3%, P < 0.001; OS: 90.9% vs. 68.7%, P = 0.08) and post-NACT (PFS: 85.0% vs. 50.6%, P < 0.001; OS: 91.7% vs. 65.7%; P = 0.001) EBV DNA levels but not for post-radiotherapy (PFS: 72.2% vs. 60.9%, P = 0.192; OS: 73.1% vs. 77.2%, P = 0.472) or post-treatment (PFS: 77.3% vs. 59.2%, P = 0.063; OS: 77.5% vs. 79.7%, P = 0.644) levels. Nomograms combining pre-NACT and post-NACT EBV DNA levels had a superior prognostic ability than those of post-radiotherapy and post-treatment EBV DNA levels.ConclusionPre-NACT EBV DNA levels combined with post-NACT EBV DNA levels can more reliably predict survival outcomes in patients with NPC.

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