scholarly journals Characterization of V‐set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells

2017 ◽  
Vol 108 (8) ◽  
pp. 1701-1714 ◽  
Author(s):  
Yusuke Inoue ◽  
Shun Matsuura ◽  
Katsuhiro Yoshimura ◽  
Yuji Iwashita ◽  
Tomoaki Kahyo ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Function ◽  
Suppressor Function ◽  
Immunoglobulin Domain ◽  
Esophageal Cancer Cells

scholarly journals Characterization of a Monoclonal Antibody to Human Esophageal Cancer Cells

1992 ◽  
Vol 25 (9) ◽  
pp. 2447-2447
Author(s):  
Genzan Shirohzu ◽  
Hideaki Yamana ◽  
Toshiaki Matsumura ◽  
Teruhiko Fujii ◽  
Uhi Toh ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Esophageal Cancer ◽  
Cancer Cells ◽  
Human Esophageal Cancer ◽  
Esophageal Cancer Cells

The expression of the tumor suppressor gene connexin 26 is not mediated by methylation in human esophageal cancer cells

2003 ◽  
Vol 36 (2) ◽  
pp. 74-81 ◽  
Author(s):  
Jadranka Loncarek ◽  
Hiroshi Yamasaki ◽  
Pierre Levillain ◽  
Serge Milinkevitch ◽  
Marc Mesnil
Keyword(s):  
Esophageal Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Connexin 26 ◽  
Human Esophageal Cancer ◽  
Esophageal Cancer Cells

scholarly journals Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor Prdx1 with Apoptosis Induction in Esophageal Cancer Cells

2005 ◽  
Vol 11 (21) ◽  
pp. 7945-7952 ◽  
Author(s):  
Isamu Hoshino ◽  
Hisahiro Matsubara ◽  
Naoyuki Hanari ◽  
Mikito Mori ◽  
Takanori Nishimori ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Apoptosis Induction ◽  
Deacetylase Inhibitor ◽  
Esophageal Cancer Cells

scholarly journals Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence

Oncogene ◽  
2019 ◽  
Vol 39 (7) ◽  
pp. 1572-1589 ◽  
Author(s):  
Zhu Wang ◽  
Youjia Li ◽  
Dinglan Wu ◽  
Shan Yu ◽  
Yuliang Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Nuclear Receptor ◽  
Cellular Senescence ◽  
Xenograft Model ◽  
Tumor Suppressor Function ◽  
Prostate Cancer Cells ◽  
Suppressor Function

Abstract Hepatocyte nuclear factor 4α (HNF4α, NR2A1) is a highly conserved member of the nuclear receptor superfamily. Recent advances reveal that it is a key transcriptional regulator of genes, broadly involved in xenobiotic and drug metabolism and also cancers of gastrointestinal tract. However, the exact functional roles of HNF4α in prostate cancer progression are still not fully understood. In this study, we determined the functional significance of HNF4α in prostate cancer. Our results showed that HNF4α exhibited a reduced expression pattern in clinical prostate cancer tissues, prostate cancer cell lines and xenograft model of castration-relapse prostate cancer. Stable HNF4α knockdown not only could promote cell proliferation and suppress doxorubicin (Dox)-induced cellular senescence in prostate cancer cells, but also confer resistance to paclitaxel treatment and enhance colony formation capacity and in vivo tumorigenicity of prostate cancer cells. On the contrary, ectopic overexpression of HNF4α could significantly inhibit the cell proliferation of prostate cancer cells, induce cell-cycle arrest at G2/M phase and trigger the cellular senescence in prostate cancer cells by activation of p21 signal pathway in a p53-independent manner via its direct transactivation of CDKN1A. Together, our results show that HNF4α performs a tumor suppressor function in prostate cancer via a mechanism of p21-driven cellular senescence.

β-Catenin Inhibits Promyelocytic Leukemia Protein Tumor Suppressor Function in Colorectal Cancer Cells

2012 ◽  
Vol 142 (3) ◽  
pp. 572-581 ◽  
Author(s):  
Reiko Satow ◽  
Miki Shitashige ◽  
Takafumi Jigami ◽  
Kiyoko Fukami ◽  
Kazufumi Honda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Promyelocytic Leukemia ◽  
Tumor Suppressor Function ◽  
Promyelocytic Leukemia Protein ◽  
Suppressor Function ◽  
Colorectal Cancer Cells
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