scholarly journals High‐mobility group box‐1 contributes tumor angiogenesis under interleukin‐8 mediation during gastric cancer progression

2017 ◽  
Vol 108 (8) ◽  
pp. 1594-1601 ◽  
Author(s):  
Hye Won Chung ◽  
Jong‐Baeck Lim
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Tumor Angiogenesis ◽  
High Mobility ◽  
Interleukin 8 ◽  
High Mobility Group ◽  
Gastric Cancer Progression

scholarly journals Role of Glycated High Mobility Group Box-1 in Gastric Cancer

2021 ◽  
Vol 22 (10) ◽  
pp. 5185
Author(s):  
Shingo Kishi ◽  
Yukiko Nishiguchi ◽  
Kanya Honoki ◽  
Shiori Mori ◽  
Rina Fujiwara-Tani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Cancer ◽  
Tumor Progression ◽  
Cancer Progression ◽  
Distant Metastasis ◽  
Primary Tumor ◽  
High Mobility ◽  
High Mobility Group ◽  
Promoting Effect ◽  
Gastric Cancer Cells

Advanced glycation end products (AGEs) are produced in response to a high-glucose environment and oxidative stress and exacerbate various diseases. Nε-(Carboxymethyl)lysine (CML) is an AGE that is produced by the glycation of lysine residues of proteins. There are a few reports on alterations in protein function due to CML modification; however, its association with cancer is not clear. We investigated the significance of CML modification in high mobility group box protein-1 (HMGB1), a cytokine that is significantly associated with cancer progression. Treatment of the gastric cancer cell lines TMK1 and MKN74 with glyoxal or glucose resulted in increased CML modification compared to untreated cells. CML-HMGB1 was modified via oxidation and more pronouncedly activated the receptor for AGE and downstream AKT and NF-κB compared to naïve HMGB1 and oxidized HMGB1. CML-HMGB1 bound with reduced affinity to DNA and histone H3, resulting in enhanced extranuclear translocation and extracellular secretion. Treatment of gastric cancer cells with CML-HMGB1 enhanced cell proliferation and invasion, sphere formation, and protection from thapsigargin-induced apoptosis, and decreased 5-FU sensitivity in comparison to HMGB1. Further, CML-HMGB1 was detected at various levels in all the 10 gastric cancer tumor specimens. HMGB1 levels correlated with primary tumor progression and distant metastasis, whereas CML-HMGB1 levels were associated with primary tumor progression, lymph node metastasis, distant metastasis, and stage. In addition, CML-HMGB1 levels correlated with oxidative stress in cancer tissues and resistance to neoadjuvant therapy. Therefore, CML modification of HMGB1 enhanced the cancer-promoting effect of HMGB1. In this study, CML-HMGB1 has been highlighted as a new therapeutic target, and analysis of the molecular structure of CML-HMGB1 is desired in the future.

scholarly journals Combined targeting of high-mobility group box-1 and interleukin-8 to control micrometastasis potential in gastric cancer

2015 ◽  
Vol 137 (7) ◽  
pp. 1598-1609 ◽  
Author(s):  
Hye Won Chung ◽  
Sunphil Jang ◽  
Hoguen Kim ◽  
Jong-Baeck Lim
Keyword(s):  
Gastric Cancer ◽  
High Mobility ◽  
Interleukin 8 ◽  
High Mobility Group

scholarly journals MiR-1284 suppresses gastric cancer progression by targeting EIF4A1

2019 ◽  
Vol Volume 12 ◽  
pp. 3965-3976 ◽  
Author(s):  
Weiyuan Wei ◽  
Wenlong Cao ◽  
Zexu Zhan ◽  
Linhai Yan ◽  
Yubo Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Gastric Cancer Progression

scholarly journals Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer

2009 ◽  
Vol 7 (1) ◽  
pp. 38 ◽  
Author(s):  
Hye Chung ◽  
Sang-Guk Lee ◽  
Heejung Kim ◽  
Duck Hong ◽  
Jae Chung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Mobility ◽  
High Mobility Group ◽  
Pathologic Features
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