scholarly journals Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications

2017 ◽  
Vol 108 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Tatsuya Ishiguro ◽  
Hirokazu Ohata ◽  
Ai Sato ◽  
Kaoru Yamawaki ◽  
Takayuki Enomoto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Clinical Applications

scholarly journals In vitro models of cancer stem cells and clinical applications

BMC Cancer ◽  
2016 ◽  
Vol 16 (S2) ◽  
Author(s):  
Sara S. Franco ◽  
Karolina Szczesna ◽  
Maria S. Iliou ◽  
Mohammed Al-Qahtani ◽  
Ali Mobasheri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
In Vitro Models ◽  
Clinical Applications

scholarly journals Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 500
Author(s):  
Hend M. Nawara ◽  
Said M. Afify ◽  
Ghmkin Hassan ◽  
Maram H. Zahra ◽  
Akimasa Seno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Cancer Stem Cells ◽  
Combination Therapy ◽  
Treatment Failure ◽  
Cancer Patients ◽  
Anticancer Drugs ◽  
Causes Of Death ◽  
Therapeutic Strategies ◽  
Clinical Applications

Paclitaxel (PTX) is a chemotherapeutical agent commonly used to treat several kinds of cancer. PTX is known as a microtubule-targeting agent with a primary molecular mechanism that disrupts the dynamics of microtubules and induces mitotic arrest and cell death. Simultaneously, other mechanisms have been evaluated in many studies. Since the anticancer activity of PTX was discovered, it has been used to treat many cancer patients and has become one of the most extensively used anticancer drugs. Regrettably, the resistance of cancer to PTX is considered an extensive obstacle in clinical applications and is one of the major causes of death correlated with treatment failure. Therefore, the combination of PTX with other drugs could lead to efficient therapeutic strategies. Here, we summarize the mechanisms of PTX, and the current studies focusing on PTX and review promising combinations.

The proteomics of cancer stem cells. Potential clinical applications for innovative research in oncology

2011 ◽  
Vol 5 (11-12) ◽  
pp. 590-602 ◽  
Author(s):  
Roberto Scatena ◽  
Patrizia Bottoni ◽  
Alessandro Pontoglio ◽  
Bruno Giardina
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Clinical Applications ◽  
Innovative Research

Molecular biology of breast cancer stem cells: Potential clinical applications

2010 ◽  
Vol 36 (6) ◽  
pp. 485-491 ◽  
Author(s):  
Nam P. Nguyen ◽  
Fabio S. Almeida ◽  
Alex Chi ◽  
Ly M. Nguyen ◽  
Deirdre Cohen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Molecular Biology ◽  
Clinical Applications ◽  
Breast Cancer Stem Cells

scholarly journals Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Hui Wang ◽  
Hongyi Zhang ◽  
Yihao Zhu ◽  
Zhonghang Wu ◽  
Chunhong Cui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Clinical Applications ◽  
Therapeutic Drug ◽  
Invasion And Migration ◽  
Tumor Growth And Metastasis ◽  
And Migration ◽  
Prevent Tumor Growth ◽  
Inhibit Cell Proliferation

Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and metastasis. To achieve better clinical outcomes, it is crucial to eradicate both bulk BC cells and breast cancer stem cells (BCSCs). Salinomycin, a monocarboxylic polyether antibiotic isolated from Streptomyces albus, can precisely kill cancer stem cells (CSCs), particularly BCSCs, by various mechanisms, including apoptosis, autophagy, and necrosis. There is increasing evidence that salinomycin can inhibit cell proliferation, invasion, and migration in BC and reverse the immune-inhibitory microenvironment to prevent tumor growth and metastasis. Therefore, salinomycin is a promising therapeutic drug for BC. In this review, we summarize established mechanisms by which salinomycin protects against BC and discuss its future clinical applications.

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