scholarly journals Antizyme inhibitor 1: a potential carcinogenic molecule

2017 ◽  
Vol 108 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Shiqiao Qiu ◽  
Jing Liu ◽  
Feiyue Xing
Keyword(s):  
Antizyme Inhibitor ◽  
Antizyme Inhibitor 1

Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines

Amino Acids ◽  
2013 ◽  
Vol 46 (3) ◽  
pp. 575-583 ◽  
Author(s):  
Yasuko Murakami ◽  
Makiko Ohkido ◽  
Hiroko Takizawa ◽  
Noriyuki Murai ◽  
Senya Matsufuji
Keyword(s):  
Multiple Forms ◽  
Antizyme Inhibitor ◽  
Antizyme Inhibitor 1

scholarly journals Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer

2021 ◽  
Author(s):  
Daryl Jin Tai Tay ◽  
Yangyang Song ◽  
Boya Peng ◽  
Tan Boon Toh ◽  
Lissa Hooi ◽  
...  
Keyword(s):  
Rna Editing ◽  
Antisense Therapy ◽  
Antizyme Inhibitor ◽  
Antizyme Inhibitor 1

scholarly journals RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers

Tumor Biology ◽  
2017 ◽  
Vol 39 (8) ◽  
pp. 101042831770000 ◽  
Author(s):  
Xueda Hu ◽  
Jingyi Chen ◽  
Xiaoshun Shi ◽  
Fenglan Feng ◽  
King Wai Lau ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Adenosine Deaminase ◽  
Rna Editing ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Antizyme Inhibitor ◽  
Antizyme Inhibitor 1

RNA editing is a widespread post-transcriptional mechanism that confers specific and reproducible nucleotide changes in selected RNA transcripts and plays a critical role in many human cancers. However, little is known about how RNA editing operates in non-small-cell lung cancers. Here, we measured the sequence and expression level of genes of antizyme inhibitor 1 and adenosine deaminase acting on RNA family in 30 non-small-cell lung cancer patient samples and 13 cell lines and revealed RNA editing S367G in antizyme inhibitor 1 is a high-frequent molecular events. We determined overexpression of antizyme inhibitor 1 with RNA editing, implying the oncogenic function of this alteration. We also detected the association of adenosine deaminase acting on RNA overexpression with RNA editing occurred in antizyme inhibitor 1. Furthermore, the RNA editing could cause a cytoplasmic-to-nuclear translocation of antizyme inhibitor 1 protein and conferred the malignant phenotype of non-small-cell lung cancer cells. The in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer.

scholarly journals Antizyme inhibitor 1 genetic polymorphisms associated with diabetic patients validated in the livers of diabetic mice

2019 ◽  
Author(s):  
Cheng‑Hsu Chen ◽  
Yeh‑Han Wang ◽  
Shang‑Feng Tsai ◽  
Tung‑Min Yu ◽  
Shih‑Yin Chen ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Diabetic Patients ◽  
Diabetic Mice ◽  
Antizyme Inhibitor ◽  
Antizyme Inhibitor 1

scholarly journals A macromolecular inhibitor of the antizyme to ornithine decarboxylase

1982 ◽  
Vol 204 (3) ◽  
pp. 647-652 ◽  
Author(s):  
K Fujita ◽  
Y Murakami ◽  
S Hayashi
Keyword(s):  
Ornithine Decarboxylase ◽  
Rat Liver ◽  
Molecular Size ◽  
Antizyme Inhibitor ◽  
Heat Labile

A macromolecular factor that inhibits the activity of the antizyme to ornithine decarboxylase (ODC) was found in rat liver extracts. The factor, ‘antizyme inhibitor’, was heat-labile, non diffusable and of similar molecular size to ODC. The antizyme inhibitor re-activated ODC that had been inactivated by antizyme, apparently by replacing ODC in a complex with antizyme. Therefore the antizyme inhibitor can be used to assay the amount of inactive ODC-antizyme complex formed in vitro. When assayed by this method, the complex was shown to be eluted before ODC from a Sephadex G-100 column. Significant increase in ODC activity was observed when the antizyme inhibitor was added to crude liver extracts from rats that had been injected with 1,3-diaminopropane to cause decay of ODC activity, suggesting the presence of inactive ODC-antizyme complex in the extracts.

scholarly journals Antizyme Inhibitor 2 Hypomorphic Mice. New Patterns of Expression in Pancreas and Adrenal Glands Suggest a Role in Secretory Processes

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69188 ◽  
Author(s):  
Carlos López-Garcia ◽  
Bruno Ramos-Molina ◽  
Ana Lambertos ◽  
Andrés J. López-Contreras ◽  
Asunción Cremades ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Antizyme Inhibitor ◽  
Antizyme Inhibitor 2
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