scholarly journals Long non‐coding RNA ROR promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma

2016 ◽  
Vol 107 (9) ◽  
pp. 1215-1222 ◽  
Author(s):  
Li Li ◽  
Miao Gu ◽  
Bo You ◽  
Si Shi ◽  
Ying Shan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Nano-Coated si-SNHG14 Regulated PD-L1 Expression and Decreased Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma Cells

2021 ◽  
Vol 17 (10) ◽  
pp. 1993-2002
Author(s):  
Haoran Yu ◽  
Chen Zhang ◽  
Wanpeng Li ◽  
Xicai Sun ◽  
Quan Liu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Animal Experiments ◽  
Loss Of Function ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Tumor Agent

To investigate the expression characteristics of long non-coding RNA SNHG14 in nasopharyngeal carcinoma (NPC) and its effects on epithelial-mesenchymal transition and development of nano-coated si-SNHG14 as an anti-tumor agent. The SNHG14 expression in cancerous and adjacent non-cancerous tissues was monitored using reverse transcriptionpolymerase chain reaction (RT-PCR). Gain- and loss-of-function experiments tested the regulation of SNHG14, miR- 5590-3p, and ZEB1 on PD-L1. The binding association between the above three factors was verified using bioinformatics analysis. EMT-related E-cadherin, N-cadherin, and Vimentin were tested using Western blot. Animal experiments in nude mice verified the function of SNHG14 in the EMT of NPC in vivo. The nano-coated si-SNHG14 was developed as an anti-tumor agent and was verified NPC cell in vitro. SNHG14 was upregulated in NPC tissues. Knocking down SNHG14 markedly inhibited the EMT of NPC. Additionally, the expression of ZEB1 was positively related to that of the SNHG14, while it was inversely correlated with that of miR-5590-3p. Moreover, ZEB1 transcription upregulated PD-L1 and promoted the EMT, while SNHG14 could accelerate the EMT of NPC in vivo by regulating the PD-1 and PD-L1. SNHG14-miR-5590- 3p-ZEB1 positively regulated PD-L1 and facilitate the EMT of NPC. Nano-coated si-SNHG14 significantly downregulated PD-L1 expression and decreased EMT.

scholarly journals LncRNA GAS5 facilitates nasopharyngeal carcinoma progression through epigenetically silencing PTEN via EZH2

RSC Advances ◽  
2019 ◽  
Vol 9 (54) ◽  
pp. 31691-31698
Author(s):  
Dan Zhao ◽  
Yujie Li ◽  
Min Yu
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Growth Arrest ◽  
Cancer Development ◽  
Specific Transcript ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Lncrna Gas5

Increasing evidence demonstrated that long non-coding RNA growth-arrest-specific transcript 5 (GAS5) serves as a critical regulator in cancer development and progression.

scholarly journals Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p

Aging ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 999-1011 ◽  
Author(s):  
Kai-Yu Sun ◽  
Tao Peng ◽  
Zhe Chen ◽  
Peng Song ◽  
Xu-Hong Zhou
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Human Nasopharyngeal Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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