scholarly journals Somatic alteration and depleted nuclear expression of BAP 1 in human esophageal squamous cell carcinoma

2015 ◽  
Vol 106 (9) ◽  
pp. 1118-1129 ◽  
Author(s):  
Takahiro Mori ◽  
Makiko Sumii ◽  
Fumiyoshi Fujishima ◽  
Kazuko Ueno ◽  
Mitsuru Emi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Nuclear Expression ◽  
Somatic Alteration

scholarly journals Nuclear Expression of Phosphorylated EGFR Is Associated with Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma

Pathobiology ◽  
2007 ◽  
Vol 74 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Mina Hoshino ◽  
Hirokazu Fukui ◽  
Yuko Ono ◽  
Akira Sekikawa ◽  
Kazuhito Ichikawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Nuclear Expression

scholarly journals Nuclear expression of Twist promotes lymphatic metastasis in esophageal squamous cell carcinoma

2012 ◽  
Vol 13 (8) ◽  
pp. 606-613 ◽  
Author(s):  
Taiqian Gong ◽  
Zengfu Xue ◽  
Shanhong Tang ◽  
Xiushan Zheng ◽  
Guanghui Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphatic Metastasis ◽  
Nuclear Expression

scholarly journals SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lei Feng ◽  
Kaikai Zhao ◽  
Liangchao Sun ◽  
Xiaoyang Yin ◽  
Junpeng Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chip Sequencing ◽  
Node Metastasis ◽  
Nuclear Expression

Abstract Background Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to clarify SLC7A11’s expression and correlation with nuclear expression of nuclear factor erythroid-2 (NRF2)-associated radioresistance in ESCC. Methods We included 127 ESCC patients who received radical chemoradiotherapy. Immunohistochemical staining was used to detect SLC7A11 and NRF2 nuclear expression, and the relationship between clinicopathological characteristics and survival rates or therapy response were evaluated. Western blot, dual-reporter assays and Chromatin immunoprecipitation (ChIP)-sequencing were used to analyze their relationship in vitro. Their roles in radioresistance were then investigated through multiple validation steps. Results NRF2 nuclear expression and SLC7A11 expression were overexpressed in ESCC tissues and were positively correlated with one another. NRF2 nuclear expression was significantly associated with tumor length, lymph node metastasis, and TNM stage, while SLC7A11 expression was associated with lymph node metastasis. Patients with high NRF2 nuclear expression and SLC7A11 expression had significantly shorter overall and progression-free survival, and poor treatment response. The multivariate model showed that NRF2 nuclear expression and SLC7A11 expression, sex and tumor location are independent prognostic factors. In vitro analysis confirmed that hyperactivation of NRF2 induced SLC7A11 expression by directly binding to its promoter region, promoting radioresistance, reducing radiotherapy-induced lipid peroxidation levels, PTGS2 expression, and radiotherapy-related ferroptosis morphologic features. Conclusion Our study reveals a connection between high SLC7A11 expression and NRF2 nuclear expression in patients with ESCC that was related to worse survival and poorer therapy outcomes. SLC7A11-mediated ferroptosis inhibition induced NRF2-associated radioresistance, highlighting potential of NRF2/SLC7A11/ferroptosis axis as future therapeutic targets against therapy resistance biomarker.

Progress of Chemoradiotherapy for Resectable Esophageal Squamous Cell Carcinoma

2012 ◽  
Vol 63 (2) ◽  
pp. 195-195
Author(s):  
K. Minashi ◽  
T. Yano ◽  
T. Kojima ◽  
M. Onozawa ◽  
K. Nihei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Resectable Esophageal
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