scholarly journals Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype

2015 ◽  
Vol 106 (8) ◽  
pp. 951-958 ◽  
Author(s):  
Naohide Oue ◽  
Kazuhiro Sentani ◽  
Naoya Sakamoto ◽  
Wataru Yasui
Keyword(s):  
Gastric Cancer ◽  
Molecular Characteristics ◽  
Mucin Phenotype ◽  
Intestinal Mucin

Overexpression of KIF11 in Gastric Cancer with Intestinal Mucin Phenotype

Pathobiology ◽  
2016 ◽  
Vol 84 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Takeharu Imai ◽  
Naohide Oue ◽  
Masahiro Nishioka ◽  
Shoichiro Mukai ◽  
Takashi Oshima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mucin Phenotype ◽  
Intestinal Mucin

Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance

2013 ◽  
Vol 137 (8) ◽  
pp. 1047-1053 ◽  
Author(s):  
Dae Hwan Kim ◽  
Nari Shin ◽  
Gwang Ha Kim ◽  
Geum Am Song ◽  
Tae-Yong Jeon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Proportional Hazard ◽  
Poor Prognostic Factor ◽  
Mucin Phenotype ◽  
Gastric Cancers ◽  
Intestinal Mucin ◽  
Mucin Expression

Context.—The clinical validity of mucin expression in gastric cancer is debated. Whereas several reports demonstrate a correlation between mucin expression and prognosis, others deny such an association. Objectives.—This survival analysis study aims to elucidate the prognostic significance of mucin expression in gastric cancer. Design.—A retrospective survival analysis was done with 412 cases of gastric cancer characterized on the basis of MUC immunohistochemistry using MUC2, MUC5AC, MUC6, and CD10 antibodies; the cases were divided into those with a gastric, an intestinal, or a null mucin phenotype based on the predominant mucin. Results.—There was no association between mucin expression and survival when considering overall gastric cancers or the advanced gastric cancer subtype. However, early gastric cancers with a gastric mucin phenotype showed longer survival than those with an intestinal mucin phenotype (P = .01) or a null phenotype (P = .01). In particular, MUC5AC-positive early gastric cancers resulted in longer survival than did those that did not express MUC5AC (P = .009). The loss of MUC5AC expression was identified as an independent, poor prognostic factor in early gastric cancers using the Cox regression proportional hazard model (hazard ratio, 3.50; P = .045). Conclusions.—MUC5AC expression is significantly associated with patient survival and can be used to predict outcomes in the gastric cancers, especially in the early gastric cancers.

scholarly journals Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis

2012 ◽  
Vol 33 (5) ◽  
pp. 1081-1088 ◽  
Author(s):  
K. Sentani ◽  
N. Oue ◽  
Y. Naito ◽  
N. Sakamoto ◽  
K. Anami ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Mucin Phenotype ◽  
Favorable Prognosis ◽  
Intestinal Mucin

scholarly journals Towards Personalization in the Curative Treatment of Gastric Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Astrid E. Slagter ◽  
Marieke A. Vollebergh ◽  
Edwin P. M. Jansen ◽  
Johanna W. van Sandick ◽  
Annemieke Cats ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Standard Of Care ◽  
Molecular Characteristics ◽  
Perioperative Chemotherapy ◽  
Current Standard ◽  
Common Cancer ◽  
Resectable Gastric Cancer

Gastric cancer is the fifth most common cancer worldwide and has a high mortality rate. In the last decades, treatment strategy has shifted from an exclusive surgical approach to a multidisciplinary strategy. Treatment options for patients with resectable gastric cancer as recommended by different worldwide guidelines, include perioperative chemotherapy, pre- or postoperative chemoradiotherapy and postoperative chemotherapy. Although gastric cancer is a heterogeneous disease with respect to patient-, tumor-, and molecular characteristics, the current standard of care is still according to a one-size-fits-all approach. In this review, we discuss the background of the different treatment strategies in resectable gastric cancer including the current standard, the specific role of radiotherapy, and describe the current areas of research and potential strategies for personalization of therapy.

Abstract 2789: Functional and molecular characteristics of 20 novel patient-derived xenografts of Asian gastric cancer.

2013 ◽  
Author(s):  
Rebekka Krumbach ◽  
Seong-Ho Kong ◽  
Woo Ho Kim ◽  
Julia Schüler ◽  
Andreas Ackermann ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Characteristics

scholarly journals Mucin phenotype of differentiated early gastric cancer: an immunohistochemistry study supporting therapeutic decision making

2019 ◽  
Vol Volume 11 ◽  
pp. 5047-5054
Author(s):  
Elisabetta Cavalcanti ◽  
Francesco De Michele ◽  
Giulio Lantone ◽  
A. Panarese ◽  
Maria Lucia Caruso
Keyword(s):  
Gastric Cancer ◽  
Decision Making ◽  
Early Gastric Cancer ◽  
Therapeutic Decision ◽  
Mucin Phenotype ◽  
Therapeutic Decision Making

scholarly journals Molecular characteristics of synchronous multiple gastric cancer

Theranostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 5489-5500
Author(s):  
Anqiang Wang ◽  
Zhongwu Li ◽  
Meng Wang ◽  
Shuqin Jia ◽  
Jiahu Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Characteristics ◽  
Multiple Gastric Cancer

Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer

2011 ◽  
Vol 46 (9) ◽  
pp. 1064-1070 ◽  
Author(s):  
Masaaki Kobayashi ◽  
Manabu Takeuchi ◽  
Yoichi Ajioka ◽  
Satoru Hashimoto ◽  
Akito Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Mucin Phenotype ◽  
Mucosal Gastric Cancer

Molecular characteristics of differentiated-type gastric carcinoma with distinct mucin phenotype: LI-cadherin is associated with intestinal phenotype

2006 ◽  
Vol 56 (4) ◽  
pp. 200-205 ◽  
Author(s):  
Junichi Motoshita ◽  
Hirofumi Nakayama ◽  
Kiyomi Taniyama ◽  
Keisuke Matsusaki ◽  
Wataru Yasui
Keyword(s):  
Gastric Carcinoma ◽  
Molecular Characteristics ◽  
Mucin Phenotype ◽  
Intestinal Phenotype
Sign in / Sign up

Export Citation Format

Share Document