scholarly journals Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a C hinese population

2014 ◽  
Vol 105 (6) ◽  
pp. 731-735 ◽  
Author(s):  
Ningbin Dai ◽  
Mingfeng Zheng ◽  
Cheng Wang ◽  
Yong Ji ◽  
Jiangbo Du ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Genetic Variants

scholarly journals Genetic variants at 9p21.3 are associated with risk of esophageal squamous cell carcinoma in a Chinese population

2017 ◽  
Vol 108 (2) ◽  
pp. 250-255 ◽  
Author(s):  
Xiaoming Lin ◽  
Caiwang Yan ◽  
Yong Gao ◽  
Jiangbo Du ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Genetic Variants ◽  
Chinese Population

Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population

2020 ◽  
Vol 41 (6) ◽  
pp. 761-768
Author(s):  
Nan Yang ◽  
Pingting Ying ◽  
Jianbo Tian ◽  
Xiaoyang Wang ◽  
Shufang Mei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Genetic Variants ◽  
Association Studies ◽  
Valuable Insight ◽  
Genome Wide Association Studies ◽  
Cancer Occurrence

Abstract N 6-methyladenosine (m6A) is an abundant modification in RNAs that affects RNA metabolism, and it is reported to be closely related to cancer occurrence and metastasis. In this study, we focused on evaluating the associations between genetic variants in m6A modification genes and the risk of esophageal squamous-cell carcinoma (ESCC). By integrating data of our previous genome-wide association studies and the predictions of several annotation tools, we identified a single nucleotide polymorphism, rs2416282 in the promoter of YTHDC2, that was significantly associated with the susceptibility of ESCC (odds ratio = 0.84, 95% CI: 0.77–0.92, P = 2.81 × 10−4). Through further functional experiments in vitro, we demonstrated that rs2416282 regulated YTHDC2 expression. Knockdown of YTHDC2 substantially promoted the proliferation rate of ESCC cells by affecting several cancer-related signaling pathways. Our results suggested that rs2416282 contributed to ESCC risk by regulating YTHDC2 expression. This study provided us a valuable insight into the roles of genetic variants in m6A modification genes for ESCC susceptibility and may contribute to the prevention of this disease in the future.

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