scholarly journals Peneciraistin C induces caspase-independent autophagic cell death through mitochondrial-derived reactive oxygen species production in lung cancer cells

2013 ◽  
Vol 104 (11) ◽  
pp. 1476-1482 ◽  
Author(s):  
Xiaohong Pan ◽  
Desheng Liu ◽  
Juan Wang ◽  
Xiuli Zhang ◽  
Miaomiao Yan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cancer Cells ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Autophagic Cell Death ◽  
Lung Cancer Cells ◽  
Oxygen Species ◽  
Species Production

MG132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH level

2010 ◽  
Vol 29 (7) ◽  
pp. 607-614 ◽  
Author(s):  
Yong Hwan Han ◽  
Woo Hyun Park
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Cell Death ◽  
Cancer Cells ◽  
Proteasome Inhibitor ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Oxygen Species ◽  
A549 Lung

Carbobenzoxy-Leu-Leu-leucinal (MG132) as a proteasome inhibitor has been shown to induce apoptotic cell death through formation of reactive oxygen species (ROS). In the present study, we evaluated the effects of MG132 on the growth of A549 lung cancer cells in relation to cell growth, ROS and glutathione (GSH) levels. Treatment with MG132 inhibited the growth of A549 cells with an IC50 of approximately 20 μM at 24 hours. DNA flow cytometric analysis indicated that 0.5 ∼ 30 μM MG132 induced a G1 phase arrest of the cell cycle in A549 cells. Treatment with 10 or 30 μM MG132 also induced apoptosis, as evidenced by sub-G1 cells and annexin V staining cells. This was accompanied by the loss of mitochondrial membrane potential (MMP; Δψm). The intracellular ROS levels including O2•- were strongly increased in 10 or 30 μM MG132-treated A549 cells but were down-regulated in 0.1, 0.5 or 1 μM MG132-treated cells. Furthermore, 10 or 30 μM MG132 increased mitochondrial O2•- level but 0.1, 0.5 or 1 μM MG132 decreased that. In addition, 10 or 30 μM MG132 induced GSH depletion in A549 cells. In conclusion, MG132 inhibited the growth of human A549 cells via inducing the cell cycle arrest as well as triggering apoptosis, which was in part correlated with the changes of ROS and GSH levels. Our present data provide important information on the anti-growth mechanisms of MG132 in A549 lung cancer cells in relation to ROS and GSH.

Curcumin exerts cytotoxicity dependent on reactive oxygen species accumulation in non-small-cell lung cancer cells

2019 ◽  
Vol 15 (11) ◽  
pp. 1243-1253 ◽  
Author(s):  
Cuijuan Wang ◽  
Xingguo Song ◽  
Ming Shang ◽  
Wei Zou ◽  
Mengping Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Oxygen Species ◽  
Small Cell Lung

scholarly journals Preventive Effect of Daiokanzoto (TJ-84) on 5-Fluorouracil-Induced Human Gingival Cell Death through the Inhibition of Reactive Oxygen Species Production

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112689 ◽  
Author(s):  
Kaya Yoshida ◽  
Masami Yoshioka ◽  
Hirohiko Okamura ◽  
Satomi Moriyama ◽  
Kazuyoshi Kawazoe ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Preventive Effect ◽  
Species Production

Resveratrol Induces Reactive Oxygen Species Production and Apoptosis in Breast Cancer Cells

2010 ◽  
Vol 49 ◽  
pp. S92-S93
Author(s):  
Paula Seixas Costa ◽  
Danielly Cristiny Ferraz Costa ◽  
Fabiana Alves Casanova ◽  
Jerson Lima Silva ◽  
Eliane Fialho Oliveira
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Species Production
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