scholarly journals Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

2013 ◽  
Vol 104 (4) ◽  
pp. 409-415 ◽  
Author(s):  
Tomonari Kinoshita ◽  
Genichiro Ishii ◽  
Nobuyoshi Hiraoka ◽  
Shunki Hirayama ◽  
Chisako Yamauchi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lung Adenocarcinoma ◽  
Cancer Associated Fibroblasts ◽  
Forkhead Box P3 ◽  
Poor Outcome ◽  
Forkhead Box

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells

2010 ◽  
Vol 126 (6) ◽  
pp. 1242-1251 ◽  
Author(s):  
Alicia N. McMurchy ◽  
Jana Gillies ◽  
Sarah E. Allan ◽  
Laura Passerini ◽  
Eleonora Gambineri ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Immune Dysregulation ◽  
Forkhead Box P3 ◽  
Forkhead Box

Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease

2014 ◽  
Vol 49 (6) ◽  
pp. 817-826 ◽  
Author(s):  
V. P. B. Parachuru ◽  
D. E. Coates ◽  
T. J. Milne ◽  
H. M. Hussaini ◽  
A. M. Rich ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Periodontal Disease ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Forkhead Box P3 ◽  
Forkhead Box

scholarly journals Evaluation of IL-17 Producing Memory Regulatory and Effector T Cells Expressing CD26 Molecule in Patients with Psoriasis

2018 ◽  
pp. 453-463
Author(s):  
Behnaz Esmaeili ◽  
Parvin Mansouri ◽  
Alipasha Meysamie ◽  
Maryam Izad
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Memory T Cells ◽  
Treg Cells ◽  
Effector Memory ◽  
Forkhead Box P3 ◽  
Forkhead Box ◽  
Significant Difference ◽  
Cytokine Levels

Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation. Human T helper-17 cells (Th-17) express high level of surface CD26, while regulatory T cells are CD26 negative or low and this phenotype is stable even after activation of Treg cells. In this study, we aimed to analyze IL-17 producing Treg cells using CD26.      Memory T cells were isolated from 10 patients with psoriasis and 10 controls. Ex vivo stimulated IL-17 producing regulatory (Forkhead Box P3 (Foxp3)+CD25+CD26-/low) and effector (Foxp3+CD25+CD26hi) memory T cells were analyzed by flow cytometry. IL-23, IL-6, TNFα, TGFβ and IL-17 cytokine levels were also evaluated. No significant difference in IL-17+memory regulatory T cells was seen between patients and controls (p=0.19). A significant decrease in the percentage of IL-17 producing CD26hi effector memory T cells was observed in patients (p=0.04). However, the percentage of these cells was not different between patients with mild or severe form of psoriasis compared to controls (p=0.13). We could not find any significant difference regarding IL-23, IL-6, TNFα, TGFβ and IL-17 cytokine levels in plasma and cell culture supernatant samples between patients and controls.  Taken together, our results showed a reduced IL-17 producing effector memory CD26hi T cells in patients with psoriasis compared to controls. However, IL-17 producing memory regulatory CD4+T cells of patients showed no significant difference from that of controls

933 INTERLEUKIN-23 RECEPTOR SIGNALING MODULATES THE STABILITY AND FUNCTION OF FORKHEAD BOX P3 POSITIVE REGULATORY T CELLS

2020 ◽  
Vol 158 (6) ◽  
pp. S-186-S-187
Author(s):  
Justin Jacobse ◽  
Jing Li ◽  
Rajeev K. Tyagi ◽  
Edmond H.H.M. Rings ◽  
Janneke N. Samsom ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Receptor Signaling ◽  
Forkhead Box P3 ◽  
Forkhead Box ◽  
Interleukin 23 ◽  
The Stability ◽  
And Function
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