Clinical implications of sperm DNA damage in IVF and ICSI : updated systematic review and meta‐analysis

2021 ◽  
Author(s):  
Jordi Ribas‐Maynou ◽  
Marc Yeste ◽  
Nerea Becerra‐Tomás ◽  
Kenneth I. Aston ◽  
Emma R. James ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Damage ◽  
Meta Analysis ◽  
Clinical Implications ◽  
Sperm Dna Damage ◽  
Sperm Dna

scholarly journals A systematic review and meta-analysis to determine the effect of sperm DNA damage on IVF and ICSI outcome

2016 ◽  
Vol 0 (0) ◽  
pp. 0 ◽  
Author(s):  
Luke Simon ◽  
Armand Zini ◽  
Alina Dyachenko ◽  
Antonio Ciampi ◽  
DouglasT Carrell
Keyword(s):  
Systematic Review ◽  
Dna Damage ◽  
Meta Analysis ◽  
Sperm Dna Damage ◽  
Sperm Dna

scholarly journals Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis

2012 ◽  
Vol 25 (3) ◽  
pp. 307-314 ◽  
Author(s):  
Ying-Jun Wang ◽  
Rong-Qiu Zhang ◽  
Yan-Jun Lin ◽  
Rong-Gui Zhang ◽  
Wei-Li Zhang
Keyword(s):  
Dna Damage ◽  
Meta Analysis ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Varicocele Repair

Clinical implications of sperm DNA damage

2010 ◽  
Vol 13 (4) ◽  
pp. 201-207 ◽  
Author(s):  
Sheena E. M. Lewis ◽  
Luke Simon
Keyword(s):  
Dna Damage ◽  
Clinical Implications ◽  
Sperm Dna Damage ◽  
Sperm Dna

scholarly journals Correlation of sperm DNA damage with blastocyst formation: systematic review and meta-analysis

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Prashanth K. Adiga ◽  
Srisailesh Vitthala ◽  
Shivaranjeni
Keyword(s):  
Dna Damage ◽  
Dna Fragmentation ◽  
Semen Analysis ◽  
Meta Analysis ◽  
Main Body ◽  
Sperm Dna Fragmentation ◽  
Blastocyst Formation ◽  
Male Factor ◽  
Sperm Dna Damage ◽  
Sperm Dna

Abstract Background The routine semen analysis fails to detect sperm DNA damage which contributes to the majority of male factor infertility. Sperm DNA fragmentation test (DFI) measures the sperm DNA damage. Blastocyst formation is an important step in IVF ± ICSI. At present, the literature lacks any data that correlates DFI and blastocyst formation. Main body of the abstract We searched MEDLINE and other databases till 2020 for the studies that reported on sperm DNA damage and blastocyst formation in assisted reproductive technology (ART). The outcomes analyzed were (1) a comparison of blastulation rates in high DFI and low DFI groups. (2) Comparison of blastulation rates in high DFI and low DFI groups based on (a) different sperm DNA fragmentation assays (COMET, SCD, SCSA, TUNEL), (b) different types of ART (IVF/IVF + ICSI/ICSI). 10 studies were included in this review. A non-significant increase in the blastocyst formation was observed in high DFI group (OR = 0.70; 95% CI = 0.4 to 1.21; P = 0.20) and with SCD and TUNEL assays. Short conclusion Our study emphasizes on sperm DNA fragmentation (sperm DNA damage) as an important marker of blastocyst formation. The results of this meta-analysis suggest that the high sperm DNA fragmentation may not adversely affect the blastocyst formation.

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