scholarly journals Deciphering mollusc shell production: the roles of genetic mechanisms through to ecology, aquaculture and biomimetics

2020 ◽  
Vol 95 (6) ◽  
pp. 1812-1837 ◽  
Author(s):  
Melody S. Clark ◽  
Lloyd S. Peck ◽  
Jaison Arivalagan ◽  
Thierry Backeljau ◽  
Sophie Berland ◽  
...  
Keyword(s):  
Mollusc Shell ◽  
Genetic Mechanisms ◽  
Shell Production

Molecular and Genetic Mechanisms of Factor XIII A Subunit Deficiency

2000 ◽  
Vol Volume 26 (Number 01) ◽  
pp. 005-010 ◽  
Author(s):  
Akitada Ichinose ◽  
Masayoshi Souri ◽  
Tomonori Izumi ◽  
Nobumasa Takahashi
Keyword(s):  
Factor Xiii ◽  
Genetic Mechanisms ◽  
A Subunit

Molecular and genetic mechanisms of pathological processes development (VIII Congress of the International Society of Pathophysiology)

2018 ◽  
pp. 281-284
Author(s):  
А.В. Кубышкин ◽  
П.Ф. Литвицкий ◽  
Л.П. Чурилов ◽  
О. Пеханова ◽  
О.И. Уразова ◽  
...  
Keyword(s):  
International Society ◽  
Genetic Mechanisms

В статье приводятся данные об основных тенденциях и направлениях развития патофизиологии как науки и образовательной дисциплины, представленных на VIII конгрессе Международного общества патофизиологов в Братиславе. The article provides information of the main trends and directions of development of Pathophysiology as a science and educational discipline, which presented at the VIII Congress of the International Society of Pathophysiology in Bratislava.

Immune and Genetic Mechanisms in COPD: Possible Targets for Therapeutic Interventions

2013 ◽  
Vol 14 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Eleni G. Tzortzaki ◽  
Alberto Papi ◽  
Eirini Neofytou ◽  
Nikolaos Soulitzis ◽  
Nikolaos M. Siafakas
Keyword(s):  
Therapeutic Interventions ◽  
Genetic Mechanisms

scholarly journals Editorial: Evolution of Genetic Mechanisms of Antibiotic Resistance

2019 ◽  
Vol 10 ◽  
Author(s):  
Silvia Buroni ◽  
Simona Pollini ◽  
Gian Maria Rossolini ◽  
Elena Perrin
Keyword(s):  
Antibiotic Resistance ◽  
Genetic Mechanisms

The Hydraulic Operation of Lathes for the Production of Shells

1944 ◽  
Vol 151 (1) ◽  
pp. 70-86
Author(s):  
W. Littlejohn Philip
Keyword(s):  
Machine Tools ◽  
Hydraulic Power ◽  
The Third ◽  
Hydraulic Machine ◽  
Hydraulic Machinery ◽  
Simple Machines ◽  
High Level ◽  
Shell Production ◽  
Hydraulic Operation ◽  
Made In

The paper is limited to the application of hydraulic power to lathes designed for shell making although, in the author's opinion, there is an immense field for the application of the same principles in other directions. Self-contained hydraulic machine tools have been dealt with by Mr. H. C. Town,† but in the system to be described all the machines are operated from a central hydraulic plant. Three complete installations on this principle have been established by the author, and the present paper contains an account of this work from the first experiments in 1915 until about four years ago. The first plant was constructed in 1915 for the production of 3·29-inch shells, known as “18-pounders”, from the solid bar. The output was 2,000 shells per week of 135 hours, with girl operators working on three shifts. The second plant was put down in 1916–17 for an output of 500 9·2-inch howitzer shells per week of 135 hours, also with girls working on three shifts. The third plant is of recent design. It was started in 1938 for the production of 3·45-inch shells, known as “25-pounders”; and was laid out for an output of 1,000 shells per week of 47 hours. This plant included four types of hydraulic lathes which the author was engaged to design for the War Office. Soon after the commencement of the last war in 1914 it became evident that shell production would have to be greatly increased, and engineering firms were pressed to take up shell manufacture. The author, on behalf of his firm, undertook to help in the movement, and he at once set about the construction of some simple machines for the job. These conformed on general lines to the practice of the period as regards design and operation. He soon realized, however, that drastic changes would have to be made if production was to reach the high level that circumstances demanded. Although quite familiar with hydraulic machinery of various types and of many applications in presses and certain types of heavy tools, he was not aware of any instance in which hydraulic power had been applied to the movements of a lathe. It appeared to him, nevertheless, that it would be possible to construct a very useful machine on these lines, and he accordingly started immediately to carry out experiments and to prepare designs. It was considered essential that machines for the duty which the author had in mind should be much heavier and more rigid than the ordinary machines of the time, so that they should be free from vibration and “chatter” or spring with the heaviest possible cutting. The standard of rigidity aimed at was that which would permit a half-crown coin to remain balanced on edge on the moving saddle or turret while the tools were making the heaviest cuts. This object was achieved, and the demonstration was frequently made in the presence of those who came to see the lathes at work.

scholarly journals Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 686
Author(s):  
Alireza Nazarian ◽  
Alexander M. Kulminski
Keyword(s):  
Nucleotide Polymorphisms ◽  
Genetic Associations ◽  
Significance Level ◽  
Association Analyses ◽  
Complex Disorders ◽  
Specific Effects ◽  
Genome Wide ◽  
Genetic Mechanisms ◽  
Sex Disparities ◽  
Almost All

Almost all complex disorders have manifested epidemiological and clinical sex disparities which might partially arise from sex-specific genetic mechanisms. Addressing such differences can be important from a precision medicine perspective which aims to make medical interventions more personalized and effective. We investigated sex-specific genetic associations with colorectal (CRCa) and lung (LCa) cancers using genome-wide single-nucleotide polymorphisms (SNPs) data from three independent datasets. The genome-wide association analyses revealed that 33 SNPs were associated with CRCa/LCa at P < 5.0 × 10−6 neither males or females. Of these, 26 SNPs had sex-specific effects as their effect sizes were statistically different between the two sexes at a Bonferroni-adjusted significance level of 0.0015. None had proxy SNPs within their ±1 Mb regions and the closest genes to 32 SNPs were not previously associated with the corresponding cancers. The pathway enrichment analyses demonstrated the associations of 35 pathways with CRCa or LCa which were mostly implicated in immune system responses, cell cycle, and chromosome stability. The significant pathways were mostly enriched in either males or females. Our findings provided novel insights into the potential sex-specific genetic heterogeneity of CRCa and LCa at SNP and pathway levels.

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