Pathological calcification in osteoarthritis: an outcome or a disease initiator?

2020 ◽  
Vol 95 (4) ◽  
pp. 960-985 ◽  
Author(s):  
Jian‐fei Yan ◽  
Wen‐pin Qin ◽  
Bo‐cheng Xiao ◽  
Qian‐qian Wan ◽  
Franklin R. Tay ◽  
...  
Keyword(s):  
Pathological Calcification

Proteomics analysis of liver pathological calcification suggests a role for the IQ motif containing GTPase activating protein 1 in myofibroblast function

2009 ◽  
Vol 3 (3) ◽  
pp. 307-321 ◽  
Author(s):  
Fariba Kalantari ◽  
Patrick Auguste ◽  
Tahereh Ziafazeli ◽  
George Tzimas ◽  
Lars Malmström ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Proteomics Analysis ◽  
Iq Motif ◽  
Pathological Calcification

Pathological Calcification of Biomaterials

2020 ◽  
pp. 973-994
Author(s):  
Frederick J. Schoen ◽  
Robert J. Levy ◽  
Hobey Tam ◽  
Naren Vyavahare
Keyword(s):  
Pathological Calcification

scholarly journals Biological Effects of Phosphate on Fibroblast-Like Synoviocytes

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Yubo Sun ◽  
David R. Mauerhan ◽  
Deepthi Chaturvedi ◽  
Edward N. Hanley ◽  
Helen E. Gruber
Keyword(s):  
Cell Death ◽  
Biological Effects ◽  
Interleukin 1 ◽  
Phosphate Transport ◽  
Dependent Manner ◽  
Expression Of Genes ◽  
Calcium Deposits ◽  
Calcification Inhibitors ◽  
Pathological Calcification ◽  
Fibroblast Like Synoviocytes

This study sought to examine the expression of genes implicated in phosphate transport and pathological calcification in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and investigate the biological effects of phosphate. Results revealed that several genes, which were implicated in phosphate transport and pathological calcification, were differentially expressed in OA FLS and RA FLS. Phosphate stimulated the expression of matrix metalloproteinse-1, matrix metalloproteinse-3, cyclooxygenase-2, and interleukin-1β in a dose-dependent manner. Phosphate also induced OA FLS cell death but not RA FLS cell death at higher concentration. Calcification inhibitors, phosphocitrate (PC), and ethane-1-hydroxy-1,1-diphosphonate (EHDP), effectively inhibited these detrimental biological effects of phosphate. These findings suggest that abnormal expression of genes implicated in phosphate transport and pathological calcification may contribute to the progression of OA through the induction of extracellular matrix-degrading enzymes, proinflammatory cytokines, cell death, and calcium deposits. Calcification inhibitors such as PC and EHDP are potent inhibitors of these detrimental biological effects of phosphate.

scholarly journals Focal ossification as one of the reasons for erroneous diagnosis of chorioretinal lesions

2019 ◽  
Vol 12 (3) ◽  
pp. 31-39 ◽  
Author(s):  
Alevtina S. Stoyukhina
Keyword(s):  
Detailed Analysis ◽  
Retinal Damage ◽  
Choroidal Hemangioma ◽  
Choroidal Osteoma ◽  
Erroneous Diagnosis ◽  
Pathological Calcification ◽  
Secondary Calcification

Focal calcifications of the retina and choroid occur usually in such well-known tumors as: retinoblastoma, choroidal osteoma, choroidal hemangioma, retinal astrocytoma. In addition, cases of idiopathic or secondary calcification are known, the most common of them is sclerochoroidal calcification. The article provides a detailed analysis of the clinical and tomographic pictures of ossifying conditions occurring in adults. It is shown that, in addition to a different ophthalmoscopic picture, these conditions are characterized by a different level of localization of the pathological calcification zone and a different stage of retinal damage.

Pharmacological Inhibition of Rac1 Activity Prevents Pathological Calcification and Enhances Tendon Regeneration

2019 ◽  
Vol 5 (7) ◽  
pp. 3511-3522
Author(s):  
Long Yang ◽  
Chenqi Tang ◽  
Yangwu Chen ◽  
Dengfeng Ruan ◽  
Erchen Zhang ◽  
...  
Keyword(s):  
Pharmacological Inhibition ◽  
Tendon Regeneration ◽  
Rac1 Activity ◽  
Pathological Calcification
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