The selective 5‐HT 1F receptor agonist lasmiditan inhibits trigeminal nociceptive processing: implications for migraine and cluster headache

2021 ◽  
Author(s):  
Marta Vila‐Pueyo ◽  
Keith Page ◽  
Paul R. Murdock ◽  
Howard J. Loraine ◽  
Amanda J. Woodrooffe ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Receptor Agonist ◽  
Nociceptive Processing

Laser-Evoked Cortical Potentials in Cluster Headache

Cephalalgia ◽  
2007 ◽  
Vol 27 (6) ◽  
pp. 510-518 ◽  
Author(s):  
J Ellrich ◽  
K Jung ◽  
D Ristic ◽  
S Said Yekta
Keyword(s):  
Cluster Headache ◽  
Normative Data ◽  
Specific Pattern ◽  
Control Side ◽  
Episodic Cluster Headache ◽  
Nociceptive Processing ◽  
Healthy Control ◽  
Deviation Pattern ◽  
Evoked Cortical Potentials ◽  
Cortical Potentials

Craniofacial nociceptive processing in patients ( n = 25) suffering from unilateral cluster headache was assessed by laser-evoked cortical potentials (LEPs). Latencies and amplitudes of late (N2, P2) and middle-latency (N1) LEPs were measured in chronic (CCH, n = 9) and episodic cluster headache (ECH, n = 17). In CCH patients on headache side N1c occurred later and P2 amplitude was smaller than on the healthy control side. In active periods of ECH patients P2 latency was shorter on the headache side. In remission periods of ECH patients the N2P2 ratio was lower on the headache side. In 19 out of 26 examinations in 25 headache patients LEP deviated from normative data in healthy controls ( n = 10) without any specific pattern of altered parameters. LEPs document pathological changes in craniofacial nociception in cluster headache. However, there seems to be no pathognomonic deviation pattern that enables reliable diagnosis of cluster headache and application of LEPs in further studies of pathophysiological mechanisms.

Sumatriptan Relaxes Isolated Porcine Ophthalmic Artery, But Inhibits VIP-Induced Relaxation

Cephalalgia ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 378-382 ◽  
Author(s):  
Maurice B Vincent ◽  
Linda R White ◽  
Inger Johanne Bakken ◽  
Ottar Sjaastad
Keyword(s):  
Cluster Headache ◽  
Vasoactive Intestinal Peptide ◽  
Therapeutic Effect ◽  
Receptor Agonist ◽  
Ophthalmic Artery ◽  
Similar Activity ◽  
Related Peptide ◽  
Vascular Bed ◽  
Calcitonin Gene ◽  
High Concentrations

Sumatriptan, a 5-hydroxytryptamine (5HT)1-like receptor agonist, is a new antimigraine drug which is also effective in cluster headache (CH), a disorder with marked ocular circulatory abnormalities. Sumatriptan could putatively exert a therapeutic effect in this vascular bed. The present study is an attempt to assess sumatriptan's vasoactivity in isolated porcine ophthalmic artery (POA) and to verify whether it has similar activity to 5HT, and whether it interferes with the vasodilation induced by calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). In contrast to 5HT, sumatriptan induced only slight contraction in POA at high concentrations. However, in some artery segments pre-contracted with PGF22a, sumatriptan induced a slight and short-lasting but marked relaxation. In addition, relaxations induced by VIP were inhibited significantly by sumatriptan, whereas CGRP effects were not influenced by the drug. Such reactions suggest that sumatriptan's effect in CH is probably unrelated to direct ocular arterial vasoconstriction.

MKC-733, a selective 5-HT3 receptor agonist, stimulates fasting human antral motility

2001 ◽  
Vol 120 (5) ◽  
pp. A460-A461 ◽  
Author(s):  
N COLEMAN ◽  
J WRIGHT ◽  
M PARKER ◽  
R SPILLER
Keyword(s):  
Receptor Agonist ◽  
Antral Motility

1197: AT-Home Efficacy of an Intranasally Administered Melanocortin Receptor Agonist, PT-141, In Men with Erectile Dysfunction (ED)

2004 ◽  
Vol 171 (4S) ◽  
pp. 316-316
Author(s):  
Hunter Wessells ◽  
Harin Padma-Nathan ◽  
Jacob Rajfer ◽  
Robert Feldman ◽  
Raymond Rosen ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Receptor Agonist ◽  
Melanocortin Receptor ◽  
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