scholarly journals Bacterial growth dynamics and PKPD relationships of rifampicin and bedaquiline in BALB/c mice

Author(s):  
Morris Muliaditan ◽  
Oscar Della Pasqua
2016 ◽  
pp. 39-44
Author(s):  
Ifra Tun Nur ◽  
Jannatun Tahera ◽  
Md Sakil Munna ◽  
M Majibur Rahman ◽  
Rashed Noor

With a previous observation of Escherichia coli growth cessation along with temperature variation within three different bacteriological culture media (nutrient agar, Luria-Bertani agar and minimal agar), current investigation further depicted on the possible growth dynamics of Escherichia coli (SUBE01) and Salmonella (SUBS01) growth and viability upon supplementation of different carbon sources (dextrose, sucrose, lactose, glycerol and tween 20) at 37°C under the aeration of 100 rpm. Viability of the tested bacterial species was assessed through the enumeration of the colony forming unit (cfu) appeared upon prescribed incubation for 12-24 hours on different agar plates consisting of the above mentioned carbon sources. Besides, to inspect the cellular phenotypic changes, morphological observations were conducted under the light microscope. Variations in bacterial growth (either growth acceleration or cessation) were further noticed through the spot tests on the agar plates. Considerable shortfalls in the culturable cells of E. coli and Salmonella spp. were noted in the minimal media separately consisting of sucrose, lactose, glycerol or tween 20 while an opposite impact of accelerated growth was noticed in the media supplied with dextrose. The data revealed a hierarchy of consequence of carbon sources as nutrient generators whereby the favourable bacterial growth and survival order of the carbon sources was estimated as dextrose > glycerol > lactose > tween 20 > sucrose.Bangladesh J Microbiol, Volume 32, Number 1-2,June-Dec 2015, pp 39-44


eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
David Duneau ◽  
Jean-Baptiste Ferdy ◽  
Jonathan Revah ◽  
Hannah Kondolf ◽  
Gerardo A Ortiz ◽  
...  

A central problem in infection biology is understanding why two individuals exposed to identical infections have different outcomes. We have developed an experimental model where genetically identical, co-housed Drosophila given identical systemic infections experience different outcomes, with some individuals succumbing to acute infection while others control the pathogen as an asymptomatic persistent infection. We found that differences in bacterial burden at the time of death did not explain the two outcomes of infection. Inter-individual variation in survival stems from variation in within-host bacterial growth, which is determined by the immune response. We developed a model that captures bacterial growth dynamics and identifies key factors that predict the infection outcome: the rate of bacterial proliferation and the time required for the host to establish an effective immunological control. Our results provide a framework for studying the individual host-pathogen parameters governing the progression of infection and lead ultimately to life or death.


2004 ◽  
Vol 21 (4) ◽  
pp. 273-286 ◽  
Author(s):  
Joanne M. Horn ◽  
Brett A. Masterson ◽  
Angel Rivera ◽  
Anabel Miranda ◽  
Michael A. Davis ◽  
...  

Science ◽  
2015 ◽  
Vol 349 (6252) ◽  
pp. 1066-1068
Author(s):  
C. Ash

2018 ◽  
Vol 247 ◽  
pp. 640-651 ◽  
Author(s):  
Amritanshu Shriwastav ◽  
Vaishali Ashok ◽  
Jeenu Thomas ◽  
Purnendu Bose

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Haydee Martínez ◽  
Joaquín Sánchez ◽  
José-Manuel Cruz ◽  
Guadalupe Ayala ◽  
Marco Rivera ◽  
...  

We applied the so-called chemical kinetics approach to complex bacterial growth patterns that were dependent on the liquid-surface-area-to-volume ratio (SA/V) of the bacterial cultures. The kinetic modeling was based on current experimental knowledge in terms of autocatalytic bacterial growth, its inhibition by the metabolite CO2, and the relief of inhibition through the physical escape of the inhibitor. The model quantitatively reproduces kinetic data of SA/V-dependent bacterial growth and can discriminate between differences in the growth dynamics of enteropathogenicE. coli,E. coli  JM83, andSalmonella typhimuriumon one hand andVibrio choleraeon the other hand. Furthermore, the data fitting procedures allowed predictions about the velocities of the involved key processes and the potential behavior in an open-flow bacterial chemostat, revealing an oscillatory approach to the stationary states.


Vox Sanguinis ◽  
2019 ◽  
Vol 114 (5) ◽  
pp. 478-486 ◽  
Author(s):  
Sandra Ramirez‐Arcos ◽  
Yuntong Kou ◽  
Marie‐Pierre Cayer ◽  
Marie‐Joëlle De Grandmont ◽  
Mélissa Girard ◽  
...  

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