Purine adducts as a presumable missing link for aristolochic acid nephropathy related cellular energy crisis, potential anti‐fibrotic prevention and treatment

2021 ◽  
Author(s):  
Gordana Kocic ◽  
Mihajlo Gajic ◽  
Katarina Tomovic ◽  
Jovan Hadzi‐Djokic ◽  
Marko Anderluh ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Energy Crisis ◽  
Missing Link ◽  
Cellular Energy ◽  
Aristolochic Acid Nephropathy ◽  
Prevention And Treatment

Enzymes Metabolizing Aristolochic Acid and their Contribution to the Development of Aristolochic Acid Nephropathy and Urothelial Cancer

2013 ◽  
Vol 14 (6) ◽  
pp. 695-705 ◽  
Author(s):  
Marie Stiborova ◽  
Vaclav Martínek ◽  
Eva Frei ◽  
Volker Arlt ◽  
Heinz Schmeiser
Keyword(s):  
Urothelial Cancer ◽  
Aristolochic Acid ◽  
Aristolochic Acid Nephropathy

scholarly journals The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy

2020 ◽  
Vol 97 (1) ◽  
pp. 119-129 ◽  
Author(s):  
Jiafa Ren ◽  
Nathan P. Rudemiller ◽  
Yi Wen ◽  
Xiaohan Lu ◽  
Jamie R. Privratsky ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Aristolochic Acid ◽  
Distal Nephron ◽  
Aristolochic Acid Nephropathy

scholarly journals Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy

2018 ◽  
Vol 5 ◽  
Author(s):  
Vedran Premužić ◽  
Vanja Ivković ◽  
Ninoslav Leko ◽  
Želimir Stipančić ◽  
Sandra Karanović ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Aristolochic Acid Nephropathy ◽  
Endemic Nephropathy

scholarly journals MP097L-ARGININE SUPPLEMENTATION IMPROVES CHRONIC KIDNEY INJURY IN EXPERIMENTAL ARISTOLOCHIC ACID NEPHROPATHY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i374-i374
Author(s):  
Inès Jadot ◽  
Vanessa Colombaro ◽  
Blanche Martin ◽  
Isabelle Habsch ◽  
Olivia Botton ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Kidney Injury ◽  
Aristolochic Acid Nephropathy ◽  
Chronic Kidney Injury ◽  
Arginine Supplementation

Chapter 7 Aristolochic Acid Nephropathy

2009 ◽  
pp. 211-227 ◽  
Author(s):  
Arthur P. Grollman ◽  
John Scarborough ◽  
Bojan Jelaković
Keyword(s):  
Aristolochic Acid ◽  
Aristolochic Acid Nephropathy

Aristolochic acid nephropathy caused by ingestion of herbal medicinal products

2015 ◽  
Author(s):  
M. Refik Gökmen ◽  
Graham M. Lord
Keyword(s):  
Aristolochic Acid ◽  
Herbal Medicines ◽  
Balkan Endemic Nephropathy ◽  
Herbal Products ◽  
Herbal Medicinal Products ◽  
Aristolochic Acid Nephropathy ◽  
Endemic Nephropathy ◽  
Risk Of Malignancy ◽  
Urothelial Malignancy ◽  
Mechanisms Of Carcinogenesis

Aristolochic acid nephropathy (AAN) is a rapidly progressive renal disease caused by the ingestion of plant products containing aristolochic acid (AA), first described in connection with the use of Chinese herbal medicines. Although the true worldwide extent of this disease is unknown, it is likely to represent a significant cause of chronic kidney disease (CKD) in many parts of the world. Furthermore, recent data have also demonstrated that AA is also the primary aetiological agent in Balkan endemic nephropathy. AAN is notable in its association with urothelial malignancy, with the mechanisms of carcinogenesis now well characterized. Aside from a possible role for corticosteroid therapy in slowing disease progression in selected patients, no disease-specific treatments have yet been shown to alter the course of this nephropathy. Therefore, prevention of exposure to AA and, in affected patients, effective management of the risk of malignancy are key principles in the approach to this condition. Although preparations containing Aristolochia spp. and herbs that can be confused or substituted for Aristolochia have been banned in many countries, other herbal products containing AA have continued to be available to consumers long after these bans have been instituted, highlighting the ongoing need for awareness of this disease.

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