scholarly journals Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity

2020 ◽  
Vol 177 (24) ◽  
pp. 5534-5554
Author(s):  
Leena Otsomaa ◽  
Jouko Levijoki ◽  
Gerd Wohlfahrt ◽  
Hugh Chapman ◽  
Ari‐Pekka Koivisto ◽  
...  
Keyword(s):  
Sodium Calcium Exchanger ◽  
Inotropic Activity ◽  
Sodium Calcium

Initial Characterization of the Feline Sodium-Calcium Exchanger Genea

1996 ◽  
Vol 779 (1) ◽  
pp. 121-125 ◽  
Author(s):  
KIMBERLY V. BARNES ◽  
MYRA M. DAWSON ◽  
DONALD R. MENICK
Keyword(s):  
Sodium Calcium Exchanger ◽  
Sodium Calcium ◽  
Initial Characterization

Identification and Characterization of a Sodium/Calcium Exchanger, NCX-1, in Osteoclasts and Its Role in Bone Resorption

2001 ◽  
Vol 283 (4) ◽  
pp. 770-775 ◽  
Author(s):  
Baljit S. Moonga ◽  
Robert Davidson ◽  
Li Sun ◽  
Olugbenga A. Adebanjo ◽  
James Moser ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Sodium Calcium Exchanger ◽  
Sodium Calcium ◽  
Identification And Characterization

scholarly journals Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila

1999 ◽  
Vol 147 (3) ◽  
pp. 659-670 ◽  
Author(s):  
K. Haug-Collet ◽  
B. Pearson ◽  
R. Webel ◽  
R.T. Szerencsei ◽  
R.J. Winkfein ◽  
...  
Keyword(s):  
Critical Role ◽  
Sodium Calcium Exchanger ◽  
Intracellular Loop ◽  
Excitable Cells ◽  
Sodium Calcium ◽  
Membrane Spanning ◽  
Membrane Spanning Domains ◽  
Antennal Disc ◽  
Stimulation Of

Sodium/calcium(-potassium) exchangers (NCX and NCKX) are critical for the rapid extrusion of calcium, which follows the stimulation of a variety of excitable cells. To further understand the mechanisms of calcium regulation in signaling, we have cloned a Drosophila sodium/calcium-potassium exchanger, Nckx30C. The overall deduced protein topology for NCKX30C is similar to that of mammalian NCKX, having five membrane-spanning domains in the NH2 terminus separated from six at the COOH-terminal end by a large intracellular loop. We show that NCKX30C functions as a potassium-dependent sodium/calcium exchanger, and is not only expressed in adult neurons as was expected, but is also expressed during ventral nerve cord development in the embryo and in larval imaginal discs. Nckx30C is expressed in a dorsal–ventral pattern in the eye-antennal disc in a pattern that is similar to, but broader than that of wingless, suggesting that large fluxes of calcium may be occurring during imaginal disc development. Nckx30C may not only function in the removal of calcium and maintenance of calcium homeostasis during signaling in the adult, but may also play a critical role in signaling during development.

Biochemical and Molecular Characterization of the Sodium-Calcium Exchanger from Bovine Rod Photoreceptors

1991 ◽  
Vol 639 (1 Sodium-Calciu) ◽  
pp. 234-244 ◽  
Author(s):  
ANITA ACHILLES ◽  
UTE FRIEDEL ◽  
WINFRIED HAASE ◽  
HELMUT REILÄNDER ◽  
NEIL J. COOK
Keyword(s):  
Molecular Characterization ◽  
Sodium Calcium Exchanger ◽  
Rod Photoreceptors ◽  
Sodium Calcium

scholarly journals Characterization of Sodium-Calcium Exchanger NCX_Mj using Fluorescent Indicators

2017 ◽  
Vol 112 (3) ◽  
pp. 274a
Author(s):  
Irina Shlosman ◽  
José Faraldo-Gómez ◽  
Joseph Mindell
Keyword(s):  
Sodium Calcium Exchanger ◽  
Fluorescent Indicators ◽  
Sodium Calcium

scholarly journals Lithium-Calcium Exchange Is Mediated by a Distinct Potassium-independent Sodium-Calcium Exchanger

2004 ◽  
Vol 279 (24) ◽  
pp. 25234-25240 ◽  
Author(s):  
Raz Palty ◽  
Ehud Ohana ◽  
Michal Hershfinkel ◽  
Micha Volokita ◽  
Vered Elgazar ◽  
...  
Keyword(s):  
Sodium Calcium Exchanger ◽  
Sodium Calcium ◽  
Calcium Exchange
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