scholarly journals Old dog, new trick: Trivalent arsenic as an immunomodulatory drug

2020 ◽  
Vol 177 (10) ◽  
pp. 2199-2214 ◽  
Author(s):  
Yishan Ye ◽  
Béatrice Gaugler ◽  
Mohamad Mohty ◽  
Florent Malard
Keyword(s):  
Trivalent Arsenic ◽  
Immunomodulatory Drug

scholarly journals A Bibliometric Evaluation of the Top 100 Cited Dimethyl Fumarate Articles

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1085
Author(s):  
Francisco Javier García-Fernández ◽  
Alba Estela García-Fernández ◽  
Ichiro Ikuta ◽  
Eduardo Nava ◽  
Julian Solis García del Pozo ◽  
...  
Keyword(s):  
Dimethyl Fumarate ◽  
Original Research ◽  
H Index ◽  
Early Access ◽  
Research Areas ◽  
Electronic Search ◽  
Time Period ◽  
The Usa ◽  
Immunomodulatory Drug ◽  
Number Of Citations

Dimethyl fumarate is a cytoprotective and immunomodulatory drug used in the treatment of multiple sclerosis. We performed a bibliometric study examining the characteristics and trends of the top 100 cited articles that include dimethyl fumarate in the title. On 21 September 2020 we carried out an electronic search in the Web of Science (WOS), seeking articles that include the following terms within the title: dimethyl fumarate, BG-12, or Tecfidera. To focus our investigation on original research, we refined the search to include only articles, early access, others, case report, and clinical trials. We obtained a total of 1115 items, which were cited 7169 times, had a citation density of 6.43 citations/item, and an h-index of 40. Around 2010, there was a jump in the number of published articles per year, rising from 5 articles/year up to 12 articles/year. We sorted all the items by the number of citations and selected the top 100 most cited (T100). The T100 had 4164 citations, with a density of 37 citations/year and contained 16 classic research articles. They were published between 1961 and 2018; the years 2010–2018 amassed nearly 80% of the T100. We noted 17 research areas with articles in the T100. Of these, the number one ranking went to neurosciences/neurology with 39 articles, and chemistry ranked second on the T100 list with 14 items. We noticed that the percentage of articles belonging to different journals changed depending on the time period. Chemistry held the highest number of papers during 1961–2000, while pharmacology andneurosciences/neurology led the 2001–2018 interval. A total of 478 authors from 145 institutions and 25 countries were included in the T100 ranking. The paper by Gold R et al. was the most successful with 14 articles, 1.823 citations and a density of 140.23 citations/year. The biotechnological company Biogen led the T100 list with 20 articles. With 59 published articles, the USA was the leading country in publications. We concluded that this study analyzed the use of and research on dimethyl fumarate from a different perspective, which will allow the readership (expert or not) to understand the relevance of classic and recent literature on this topic.

scholarly journals Different Effects of the Immunomodulatory Drug GMDP Immobilized onto Aminopropyl Modified and Unmodified Mesoporous Silica Nanoparticles upon Peritoneal Macrophages of Women with Endometriosis

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Yuliya Antsiferova ◽  
Nataliya Sotnikova ◽  
Elena Parfenyuk
Keyword(s):  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Topical Delivery ◽  
Peritoneal Macrophages ◽  
Scavenger Receptors ◽  
Membrane Expression ◽  
Unmodified Silica ◽  
Immunomodulatory Drug ◽  
High Level

The aim of the present work was to compare in vitro the possibility of application of unmodified silica nanoparticles (UMNPs) and modified by aminopropyl groups silica nanoparticles (AMNPs) for topical delivery of immunomodulatory drug GMDP to the peritoneal macrophages of women with endometriosis. The absence of cytotoxic effect and high cellular uptake was demonstrated for both types of silica nanoparticles. The immobilization of GMDP on the UMNPs led to the suppression of the stimulatory effect of GMDP on the membrane expression of scavenger receptors SR-AI and SR-B, mRNAs expression of NOD2 and RAGE, and synthesis of proteolytic enzyme MMP-9 and its inhibitor TIMP-1. GMDP, immobilized onto AMNPs, enhanced the initially reduced membrane expression of SRs and increased NOD2, RAGE, and MMP-9 mRNAs expression by macrophages. Simultaneously high level of mRNAs expression of factors, preventing undesirable hyperactivation of peritoneal macrophages (SOCS1 and TIMP-1), was observed in macrophages incubated in the presence of GMDP, immobilized onto AMNPs. The effect of AMNPs immobilized GMDP in some cases exceeded the effect of free GMDP. Thus, among the studied types of silica nanoparticles, AMNPs are the most suitable nanoparticles for topical delivery of GMDP to the peritoneal macrophages.

T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide

2003 ◽  
Vol 74 (6) ◽  
pp. 1083-1093 ◽  
Author(s):  
Esther Layseca-Espinosa ◽  
Gustavo Pedraza-Alva ◽  
José Luis Montiel ◽  
Roxana del Río ◽  
Nora A. Fierro ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Aggregation ◽  
Intracellular Signals ◽  
Immunomodulatory Drug

scholarly journals Blood parameters and reproductive function of highly productive cows using an organic immunomodulatory drug

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Murat Baimishev ◽  
Sergey Eremin ◽  
Hamidulla Baimishev ◽  
Kirill Plymyashov ◽  
Georgy Nikitin ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Blood Parameters ◽  
Immunomodulatory Drug

scholarly journals Evaluation of The Therapeutic Regimen in COVID-19 in Transplant Patients: Where Do Immunomodulatory and Antivirals Stand?

2021 ◽  
Author(s):  
Mojtaba Shafiekhani ◽  
Farbod Shahabinezhad ◽  
Tahmoores Niknam ◽  
Seyed Ahmad Tara ◽  
Elham Haem ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Organ Transplant ◽  
P Value ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Clinical Complications ◽  
Hospitalization Period ◽  
Significant Difference ◽  
Immunocompromised Status ◽  
Immunomodulatory Drug

Abstract Background The management of COVID-19 in organ transplant recipients is among the most imperative, yet less discussed, issues based on their immunocompromised status along with their vast post-transplant medication regimens. No conclusive study has been published to evaluate proper anti-viral and immunomodulator medications effect in treating COVID-19 patients to this date. Method: This retrospective study was conducted in Shiraz Transplant Hospital, Iran from March 2020 to May 2021 and included COVID-19 diagnosed patients based on SARS-CoV-2 RT-PCR positive test who had been hospitalized for at least 48 hours before enrolling in the study. Clinical and demographic information of patients, along with their treatment course and the medication used were evaluated and analyzed using multiple regression analysis. Results A total of 245 patients with a mean age of 49.59 years were included with a mortality rate of 8.16%. The administration of Remdesivir as an anti-viral drug (P-value˂0.001) and Tocilizumab as an immunomodulator drug (P-value < 0.001) could reduce the hospitalization period in the hospital and the intensive care unit, as well as the mortality rates significantly. Meanwhile, the patients treated with Lopinavir/Ritonavir experienced a lower chance of survival (OR < 1, P-value = 0.04). No significant difference was observed between various therapeutic regimens in clinical complications such as bacterial coinfections, cardiovascular and gastrointestinal adverse reactions, and liver or kidney dysfunctions. Conclusion The administration of Remdesivir as an anti-viral and Tocilizumab as an immunomodulatory drug in SOT recipients could be promising treatments of choice to manage COVID-19.

scholarly journals Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on NA+ transport in frog skin

2019 ◽  
Vol 484 (5) ◽  
pp. 629-632
Author(s):  
Z. I. Krutetskaya ◽  
A. V. Melnitskaya ◽  
V. G. Antonov ◽  
A. D. Nozdrachev
Keyword(s):  
Voltage Clamp ◽  
Frog Skin ◽  
Na Transport ◽  
Receptor Antagonists ◽  
Sigma 1 Receptor ◽  
Voltage Clamp Technique ◽  
Frog Skin Epithelium ◽  
Sigma 1 ◽  
Immunomodulatory Drug ◽  
First Time

Using voltage-clamp technique, the involvement of sigma-1 receptors in immunomodulatory drug glutoxim regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with sigma-1 receptor antagonists – haloperidol or chlorpromazine – attenuates the stimulatory effect of glutoxim on Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in glutoxim effect on Na+transport in frog skin epithelium.

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