scholarly journals Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase

2020 ◽  
Vol 177 (12) ◽  
pp. 2765-2778 ◽  
Author(s):  
Damian D. Guerra ◽  
Rachael Bok ◽  
Ramón A. Lorca ◽  
K. Joseph Hurt
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Nitric Oxide Synthase ◽  
Protein Kinase A ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Kinase A ◽  
Mouse Ileum

Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors

2002 ◽  
Vol 99 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Jianqiang Yu ◽  
Long Yu ◽  
Zheng Chen ◽  
Lihua Zheng ◽  
Xiaosong Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Nitric Oxide Synthase ◽  
Protein Kinase A ◽  
Neuronal Nitric Oxide Synthase ◽  
Protein Inhibitor ◽  
Oxide Synthase ◽  
Kinase A

scholarly journals Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 117 ◽  
Author(s):  
Pablo Llévenes ◽  
Raquel Rodrigues-Díez ◽  
Laia Cros-Brunsó ◽  
Mᵃ Isabel Prieto ◽  
Laura Casaní ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Protein Kinase ◽  
Nitric Oxide Synthase ◽  
Protein Kinase A ◽  
Neuronal Nitric Oxide Synthase ◽  
The Body ◽  
Oxide Synthase ◽  
Kinase A

A high fat diet (HFD) intake is crucial for the development and progression of metabolic syndrome (MtS). Increasing evidence links gut dysbiosis with the metabolic and vascular alterations associated with MtS. Here we studied the use of a combination of various probiotic strains together with a prebiotic (synbiotic) in a commercially available Prodefen® Plus. MtS was induced by HFD (45%) in male Wistar rats. Half of the MtS animals received Prodefen® Plus for 4 weeks. At 12 weeks, we observed an increase in body weight, together with the presence of insulin resistance, liver steatosis, hypertriglyceridemia and hypertension in MtS rats. Prodefen® Plus supplementation did not affect the body weight gain but ameliorated all the MtS-related symptoms. Moreover, the hypertension induced by HFD is caused by a diminished both nitric oxide (NO) functional role and release probably due to a diminished neuronal nitric oxide synthase (nNOS) activation by protein kinase A (PKA) pathway. Prodefen® Plus supplementation for 4 weeks recovered the NO function and release and the systolic blood pressure was returned to normotensive values as a result. Overall, supplementation with Prodefen® Plus could be considered an interesting non-pharmacological approach in MtS.

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