scholarly journals Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative

2019 ◽  
Vol 176 (20) ◽  
pp. 3924-3938 ◽  
Author(s):  
Aisling Minard ◽  
Claudia C. Bauer ◽  
Eulashini Chuntharpursat‐Bon ◽  
Isabelle B. Pickles ◽  
David J. Wright ◽  
...  
Keyword(s):  
Xanthine Derivative ◽  
Trpc5 Channels

scholarly journals Effects of Propentofylline on Hypoxia—Hypoglycemia-Induced Calcium Accumulation in Gerbil Hippocampal Slices

1992 ◽  
Vol 12 (2) ◽  
pp. 301-305 ◽  
Author(s):  
Fumito Kadoya ◽  
Akira Mitani ◽  
Tatsuru Arai ◽  
Kiyoshi Kataoka
Keyword(s):  
Cerebral Ischemia ◽  
Intracellular Calcium ◽  
Neuronal Damage ◽  
Hippocampal Slices ◽  
Dependent Manner ◽  
Protective Effects ◽  
Calcium Accumulation ◽  
Xanthine Derivative ◽  
Acute Increase ◽  
Dose Dependent

The xanthine derivative propentofylline (HWA 285) has been reported to show protective effects against neuronal damage induced by cerebral ischemia. In the present study, microfluorometry was used to investigate the effect of propentofylline on the hypoxia–hypoglycemia-induced intracellular calcium accumulation in gerbil hippocampal slices. When slices were superfused with hypoxic–hypoglycemic medium that did not contain propentofylline, an acute increase in calcium accumulation was detected 75–200 s (mean latency of 123 s) after the beginning of hypoxia–hypoglycemia. When slices were superfused with hypoxic–hypoglycemic mediums that contained 10 μ M, 100 μ M, and 1 m M propentofylline, the latency of the acute increase in calcium accumulation was prolonged in all subregions of the hippocampus in a dose-dependent manner: mean latencies in field CA1 were 146, 168, and 197 s after hypoxia–hypoglycemia, respectively. This retardation in calcium accumulation may be involved in the mechanisms by which propentofylline diminishes ischemic injury.

Xanthine Derivative KMUP-1 Reduces Inflammation and Hyperalgesia in a Bilateral Chronic Constriction Injury Model by Suppressing MAPK and NFκB Activation

2014 ◽  
Vol 11 (5) ◽  
pp. 1621-1631 ◽  
Author(s):  
Zen-Kong Dai ◽  
Ting-Chun Lin ◽  
Jau-Cheng Liou ◽  
Kuang-I Cheng ◽  
Jun-Yih Chen ◽  
...  
Keyword(s):  
Chronic Constriction Injury ◽  
Xanthine Derivative ◽  
Injury Model ◽  
Chronic Constriction Injury Model

scholarly journals Critical Role of Pertussis Toxin Sensitive G Proteins in the Activation of TRPC4 and TRPC5 Channels

2010 ◽  
Vol 98 (3) ◽  
pp. 326a-327a
Author(s):  
Rui Xiao ◽  
Jinbin Tian ◽  
Jisen Tang ◽  
Alexander V. Zholos ◽  
Michael X. Zhu
Keyword(s):  
G Proteins ◽  
Pertussis Toxin ◽  
Critical Role ◽  
Trpc5 Channels

Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs

1993 ◽  
Vol 249 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Stefano Manzini ◽  
Francesca Perretti ◽  
Luigi Abelli ◽  
Stefano Evangelista ◽  
Esther A.M. Seeds ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Guinea Pigs ◽  
Airway Hyperresponsiveness ◽  
Xanthine Derivative

Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells

2000 ◽  
Vol 279 (6) ◽  
pp. C1925-C1937 ◽  
Author(s):  
Laurence Bulteau ◽  
Renaud Dérand ◽  
Yvette Mettey ◽  
Thierry Métayé ◽  
M. Rachel Morris ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Short Circuit ◽  
Cystic Fibrosis Gene ◽  
Intracellular Camp ◽  
Airway Epithelial ◽  
Whole Cell ◽  
Xanthine Derivative ◽  
Human Airway ◽  
High Level

The pharmacological activation of the cystic fibrosis gene protein cystic fibrosis transmembrane conductance regulator (CFTR) was studied in human airway epithelial Calu-3 cells, which express a high level of CFTR protein as assessed by Western blot and in vitro phosphorylation. Immunolocalization shows that CFTR is located in the apical membrane. We performed iodide efflux, whole cell patch-clamp, and short-circuit recordings to demonstrate that the novel synthesized xanthine derivative 3,7-dimethyl-1-isobutylxanthine (X-33) is an activator of the CFTR channel in Calu-3 cells. Whole cell current activated by X-33 or IBMX is linear, inhibited by glibenclamide and diphenylamine-2-carboxylate but not by DIDS or TS-TM calix[4]arene. Intracellular cAMP was not affected by X-33. An outwardly rectifying Cl− current was recorded in the absence of cAMP and X-33 stimulation, inhibited by DIDS and TS-TM calix[4]arene. With the use of short-circuit recordings, X-33 and IBMX were able to stimulate a large concentration-dependent CFTR transport that was blocked by glibenclamide but not by DIDS. Our results show that manipulating the chemical structure of xanthine derivatives offers an opportunity to identify further specific activators of CFTR in airway cells.

scholarly journals Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

2015 ◽  
Vol 172 (14) ◽  
pp. 3495-3509 ◽  
Author(s):  
Yingmin Zhu ◽  
Yungang Lu ◽  
Chunrong Qu ◽  
Melissa Miller ◽  
Jinbin Tian ◽  
...  
Keyword(s):  
Trpc5 Channels

scholarly journals Pecularities of lipid peroxidation in conditions of acute respiratory distress syndrome and its correction

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
O. V. Oliynyk ◽  
S. O. Savchuk ◽  
D. B. Korobko
Keyword(s):  
Lipid Peroxidation ◽  
Acute Respiratory Distress Syndrome ◽  
Hydrochloric Acid ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Diene Conjugate ◽  
Xanthine Derivative

<p>The article considers insufflation of oxygen, xanthine derivative – salt 3-(8-brom-1,3-dymethyl-2,6-dioxo-2,3-<br />dihidro-1Н-purin-7(6Н)-il)propanoat (substance “KD-234”) and reamberin efficiency on the parameters of lipid<br />peroxidation (LPO) in middle-steady and low-steady to hypoxia rats with hydrochloric acid-inducedacute respiratory<br />distress syndrome.<br />It was established, that during experimental acute respiratory distress syndromein tissue of liver thecontentof<br />TBA-active metabolits, diene and triene conjugate statistically reliably increase, moreover in middle-steady to hypoxia<br />rats the value of TBA-active metabolits and diene conjugate in this condition substantially less, than in low-steady to<br />hypoxia rats. The use with corrective purpose of oxygen insufflation promotеs to substantial decreasing of TBA-active<br />metabolits concentration in both experimental groups, moreover in middle-steady to hypoxia rats the rate become<br />reliably substantially less, than in low-steady to hypoxia rats. The useof xanthine derivative – substance “KD-234”<br />and reamberinis accompanied by similar deviations in content of TBA-active metabolitsin hepar tissue.</p>

scholarly journals TRPC5 Channels are Inhibited by Wt Presenilin1 but not the Alzheimer's Disease Mutant M146V

2017 ◽  
Vol 112 (3) ◽  
pp. 406a
Author(s):  
Sukhjinder Kaur ◽  
Zuleen Chia-Chang ◽  
Paris Hanson ◽  
Laura Yorke ◽  
Zafir Buraei
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Trpc5 Channels

Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels

2012 ◽  
Vol 83 (7) ◽  
pp. 923-931 ◽  
Author(s):  
Hongni Jiang ◽  
Bo Zeng ◽  
Gui-Lan Chen ◽  
David Bot ◽  
Sarah Eastmond ◽  
...  
Keyword(s):  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Trpc5 Channels
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