scholarly journals Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation

2018 ◽  
Vol 175 (20) ◽  
pp. 3928-3946 ◽  
Author(s):  
Rou-Ling Cho ◽  
Chien-Chung Yang ◽  
Hui-Ching Tseng ◽  
Li-Der Hsiao ◽  
Chih-Chung Lin ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Antioxidant Response ◽  
Response Elements ◽  
Antioxidant Response Elements ◽  
Haem Oxygenase

ZFARED: A Database of the Antioxidant Response Elements in Zebrafish

2020 ◽  
Vol 15 (5) ◽  
pp. 415-419
Author(s):  
Azhwar Raghunath ◽  
Raju Nagarajan ◽  
Ekambaram Perumal
Keyword(s):  
Target Genes ◽  
Antioxidant Response ◽  
Zebrafish Genome ◽  
Promoter Regions ◽  
Protein Coding ◽  
Response Elements ◽  
Toxic Agents ◽  
Upstream Promoter ◽  
Its Gene ◽  
Antioxidant Response Elements

Background: Antioxidant Response Elements (ARE) play a key role in the expression of Nrf2 target genes by regulating the Keap1-Nrf2-ARE pathway, which offers protection against toxic agents and oxidative stress-induced diseases. Objective: To develop a database of putative AREs for all the genes in the zebrafish genome. This database will be helpful for researchers to investigate Nrf2 regulatory mechanisms in detail. Methods: To facilitate researchers functionally characterize zebrafish AREs, we have developed a database of AREs, Zebrafish Antioxidant Response Element Database (ZFARED), for all the protein-coding genes including antioxidant and mitochondrial genes in the zebrafish genome. The front end of the database was developed using HTML, JavaScript, and CSS and tested in different browsers. The back end of the database was developed using Perl scripts and Perl-CGI and Perl- DBI modules. Results: ZFARED is the first database on the AREs in zebrafish, which facilitates fast and efficient searching of AREs. AREs were identified using the in-house developed Perl algorithms and the database was developed using HTML, JavaScript, and Perl-CGI scripts. From this database, researchers can access the AREs based on chromosome number (1 to 25 and M for mitochondria), strand (positive or negative), ARE pattern and keywords. Users can also specify the size of the upstream/promoter regions (5 to 30 kb) from transcription start site to access the AREs located in those specific regions. Conclusion: ZFARED will be useful in the investigation of the Keap1-Nrf2-ARE pathway and its gene regulation. ZFARED is freely available at http://zfared.buc.edu.in/.

Genome-wide identification and analysis of Nrf2 binding sites – Antioxidant response elements in zebrafish

2018 ◽  
Vol 360 ◽  
pp. 236-248 ◽  
Author(s):  
Azhwar Raghunath ◽  
Raju Nagarajan ◽  
Kiruthika Sundarraj ◽  
Lakshmikanthan Panneerselvam ◽  
Ekambaram Perumal
Keyword(s):  
Binding Sites ◽  
Antioxidant Response ◽  
Response Elements ◽  
Genome Wide ◽  
Antioxidant Response Elements

scholarly journals Identification of polymorphic antioxidant response elements in the human genome

2007 ◽  
Vol 16 (22) ◽  
pp. 2780-2780 ◽  
Author(s):  
X. Wang ◽  
D. J. Tomso ◽  
B. N. Chorley ◽  
H.-Y. Cho ◽  
V. G. Cheung ◽  
...  
Keyword(s):  
Human Genome ◽  
Antioxidant Response ◽  
Response Elements ◽  
Antioxidant Response Elements

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

2008 ◽  
Vol 477 (1) ◽  
pp. 139-145 ◽  
Author(s):  
Atsushi Maruyama ◽  
Saho Tsukamoto ◽  
Keizo Nishikawa ◽  
Aruto Yoshida ◽  
Nobuhiko Harada ◽  
...  
Keyword(s):  
Antioxidant Response ◽  
Response Elements ◽  
Antioxidant Response Elements

scholarly journals A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

Redox Biology ◽  
2018 ◽  
Vol 19 ◽  
pp. 235-249 ◽  
Author(s):  
Daniel C. Levings ◽  
Xuting Wang ◽  
Derek Kohlhase ◽  
Douglas A. Bell ◽  
Matthew Slattery
Keyword(s):  
Antioxidant Response ◽  
Response Elements ◽  
Distinct Class ◽  
Antioxidant Response Elements
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