scholarly journals Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP-eGFP knock-in mice

2018 ◽  
Vol 175 (13) ◽  
pp. 2662-2675 ◽  
Author(s):  
Akihiko Ozawa ◽  
Gloria Brunori ◽  
Andrea Cippitelli ◽  
Nicholas Toll ◽  
Jennifer Schoch ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Model ◽  
Nop Receptors

scholarly journals Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243325
Author(s):  
Hisakatsu Ito ◽  
Yoshinori Takemura ◽  
Yuta Aoki ◽  
Mizuki Hattori ◽  
Hideyo Horikawa ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Sleep Disturbance ◽  
Thermal Hyperalgesia ◽  
Sleep Time ◽  
Tricyclic Antidepressant ◽  
Preclinical Model ◽  
Pain Model ◽  
Sleep Quantity ◽  
Sleep Condition ◽  
Neuropathic Pain Model

Chronic pain and sleep have a bidirectional relationship that promotes a vicious circle making chronic pain more difficult to treat. Therefore, pain and sleep should be treated simultaneously. In our previous study, we suggested that hyperactivation of ascending serotonergic neurons could cause secondary sleep disturbance in chronic pain. This study aimed to demonstrate the effects of a tricyclic antidepressant (amitriptyline) and a selective 5-hydroxy-tryptamine 2A (5-HT2A) antagonist (MDL 100907) that adjust serotonergic transmission, on secondary sleep disturbance induced in a preclinical chronic pain model. We produced a chronic neuropathic pain model by partial sciatic nerve ligation in mice, analyzed their electroencephalogram (EEG) and electromyogram (EMG) using the SleepSign software, and evaluated the sleep condition of the pain model mice after administration of amitriptyline or MDL 100907. Amitriptyline improved thermal hyperalgesia and the amount of sleep, especially non-REM sleep. Time change of normalized power density of δ wave in the nerve ligation group with amitriptyline administration showed a normal pattern that was similar to sham mice. In addition, MDL 100907 normalized sleep condition similar to amitriptyline, without improvement in pain threshold. In conclusion, amitriptyline could improve sleep quantity and quality impaired by chronic pain. 5-HT2A receptor antagonism could partially contribute to this sleep improvement, but is not associated with pain relief.

A Rat Chronic Pain Model of Spinal Cord Contusion Injury

2012 ◽  
pp. 195-203 ◽  
Author(s):  
Kelli Sharp ◽  
Amin Boroujerdi ◽  
Oswald Steward ◽  
Z. David Luo
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Pain Model ◽  
Contusion Injury ◽  
Spinal Cord Contusion

Influences of Suvorexant and Mirtazapine on Chronic Pain-related Sleep Disorder in Neuropathic Pain Model Mice 

2021 ◽  
Author(s):  
Hisakatsu Ito ◽  
Hiroshi Tusneki ◽  
Toshiyasu Sasaoka ◽  
Naoki Toyooka ◽  
Mitsuaki Yamazaki
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Sleep Disorders ◽  
Sleep Onset ◽  
Voluntary Activity ◽  
Pain Model ◽  
Neuropathic Pain Model ◽  
Pain State ◽  
Serotonergic Antidepressant

Abstract Chronic pain and sleep disorders are independently associated with a reduction in the quality of life. They can be both a cause and consequence of each other; therefore, they should be treated simultaneously. However, optimal treatments for chronic pain-related sleep disorders are not well established. Here, we aimed to investigate the effects of suvorexant, a novel sleep drug, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, on pain-related sleep disorders in a preclinical neuropathic pain mouse model, which was produced by partial sciatic nerve ligation. We calculated the quantity, duration, and depth of sleep by analyzing the electroencephalogram. Voluntary activity was also evaluated by counting the number of wheel rotations with special cages. Daily administration of suvorexant and mirtazapine normalized the reduced rapid eye movement (REM) and non-REM sleep and improved the fragmented sleep, further regaining the depth of sleep at sleep onset in the chronic pain state. Suvorexant decreased voluntary activity, which was prolonged after the end of administration; however, mirtazapine did not decrease it. Both suvorexant and mirtazapine could be potential therapeutic agents for chronic pain-related sleep disorders.

IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model

2020 ◽  
Author(s):  
Candelaria Leiguarda ◽  
Constanza Potilinski ◽  
Julia Rubione ◽  
Pablo Tate ◽  
Marcelo J. Villar ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Cell Infiltrate ◽  
Pain Model ◽  
Inflammatory Milieu

scholarly journals Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Claudio Laurido ◽  
Alejandro Hernández ◽  
Teresa Pelissier ◽  
Luis Constandil
Keyword(s):  
Chronic Pain ◽  
Aspartic Acid ◽  
Antinociceptive Effect ◽  
Serine Racemase ◽  
Pain Model ◽  
Acid Receptor ◽  
Culture Cells ◽  
Antinociceptive Effects ◽  
Nmdar Activation

N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence of D-serine, synthesized from L-serine by a pyridoxal 5′-phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the racemization of L-serine. L-serine-O-sulfate (LSOS) and L-erythro-3-hydroxyaspartate (LEHA), among others, have proven to be effective in reducing the D-serine levels in culture cells. It is tempting then to try these compounds in their effectiveness to decrease nociceptive levels in rat arthritic pain. We measured the C-reflex paradigm and wind-up potentiation in the presence of intrathecally injected LSOS (100 μg/10 μL) and LEHA (100 μg/10 μL) in normal and monoarthritic rats. Both compounds decreased the wind-up activity in normal and monoarthritic rats. Accordingly, all the antinociceptive effects were abolished when 300 μg/10 μL of D-serine were injected intrathecally. Since noin vivoresults have been presented so far, this constitutes the first evidence that SR inhibitions lower the D-serine levels, thus decreasing the NMDAr activity and the consequent development and maintenance of chronic pain.

scholarly journals Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Guo-Qiang Wang ◽  
Cheng Cen ◽  
Chong Li ◽  
Shuai Cao ◽  
Ning Wang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Prelimbic Cortex ◽  
Cyclin Dependent Kinase ◽  
Pain Sensation ◽  
Pain Model ◽  
Excitatory Neurons ◽  
Affective Pain ◽  
Underlying Mechanisms ◽  
Cyclin Dependent Kinase 5

Abstract The medial prefrontal cortex (mPFC) is implicated in processing sensory-discriminative and affective pain. Nonetheless, the underlying mechanisms are poorly understood. Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC, in the regulation of pain sensation and anxiety-like behaviours. Using a chronic inflammatory pain model, we show that lesion of the PL contralateral but not ipsilateral to the inflamed paw attenuates hyperalgesia and anxiety-like behaviours in rats. Optogenetic activation of contralateral PL excitatory neurons exerts analgesic and anxiolytic effects in mice subjected to chronic pain, whereas inhibition is anxiogenic in naive mice. The intrinsic excitability of contralateral PL excitatory neurons is decreased in chronic pain rats; knocking down cyclin-dependent kinase 5 reverses this deactivation and alleviates behavioural impairments. Together, our findings provide novel insights into the role of PL excitatory neurons in the regulation of sensory and affective pain.

Organizational systems in paediatric pain

2013 ◽  
pp. 642-652
Author(s):  
Mark Embrett ◽  
Norman Buckley
Keyword(s):  
Chronic Pain ◽  
Acute Pain ◽  
Patient Flow ◽  
Organizational Systems ◽  
Management Approach ◽  
Flow Process ◽  
Pain Model ◽  
Multidisciplinary Pain Management ◽  
Pain Services ◽  
Similar Elements

This chapter first focuses on an overview of the similar elements to approaches of chronic pain, acute pain, and palliative care, concluding with a description of the ideal multidisciplinary pain management approach (MPMA). The chapter then proceeds to review the specific organization and operations of acute pain and chronic pain services, respectively. Finally, research about the expectation of parents when they enter a clinic and importance of accommodating and promoting positive expectations is presented. The patient flow process in acute pain differs from the chronic pain model and is described. The emphasis remains on consistent clear communication among providers and between providers and patient/family.

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