scholarly journals Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis

2018 ◽  
Vol 175 (9) ◽  
pp. 1535-1547 ◽  
Author(s):  
Sarah J MacEachern ◽  
Catherine M Keenan ◽  
Evangelia Papakonstantinou ◽  
Keith A Sharkey ◽  
Bhavik Anil Patel
Keyword(s):  
Sodium Sulfate ◽  
Colonic Mucosa ◽  
Dextran Sodium Sulfate

scholarly journals The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Aleksandra Matuszyk ◽  
Dagmara Ceranowicz ◽  
Zygmunt Warzecha ◽  
Piotr Ceranowicz ◽  
Krzysztof Fyderek ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Sodium Sulfate ◽  
Colonic Mucosa ◽  
Body Weight Gain ◽  
Interleukin 1 ◽  
Mucosal Damage ◽  
Dextran Sodium Sulfate ◽  
Therapeutic Effects ◽  
Preventive Effect ◽  
Effect Of Treatment

Ghrelin has protective and therapeutic effects in the gut. The aim of present studies was to investigate the effect of treatment with ghrelin on the development of colitis evoked by dextran sodium sulfate (DSS). Methods. Studies have been performed on rats. Colitis was induced by adding 5% DSS to the drinking water for 5 days. During this period animals were treated intraperitoneally twice a day with saline or ghrelin given at the dose of 8 nmol/kg/dose. On the sixth day, animals were anesthetized and the severity of colitis was assessed. Results. Treatment with ghrelin during administration of DSS reduced the development of colitis. Morphological features of colonic mucosa exhibited a reduction in the area and deep of mucosal damage. Ghrelin reversed the colitis-induced decrease in blood flow, DNA synthesis, and superoxide dismutase activity in colonic mucosa. These effects were accompanied by a decrease in the colitis-evoked increase in mucosal concentration of interleukin-1β and malondialdehyde. Treatment with ghrelin reversed the DSS-induced reduction in body weight gain. Conclusions. Administration of ghrelin exhibits the preventive effect against the development of DSS-induced colitis. This effect seems to be related to ghrelin’s anti-inflammatory and antioxidative properties.

scholarly journals Erratum: Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

2014 ◽  
Vol 7 (6) ◽  
pp. 1504-1504 ◽  
Author(s):  
D Demon ◽  
A Kuchmiy ◽  
A Fossoul ◽  
Q Zhu ◽  
T-D Kanneganti ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Colonic Mucosa ◽  
Dextran Sodium Sulfate

scholarly journals Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

2014 ◽  
Vol 7 (6) ◽  
pp. 1480-1491 ◽  
Author(s):  
D Demon ◽  
A Kuchmiy ◽  
A Fossoul ◽  
Q Zhu ◽  
T-D Kanneganti ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Colonic Mucosa ◽  
Dextran Sodium Sulfate

Naringin protects against dextran sodium sulfate-induced colitis in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
E Giner ◽  
M Marin ◽  
C Recio ◽  
J Ríos ◽  
R Giner
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

Comparative effects of STW 5 and STW 5-II in dextran sodium sulfate-induced colitis

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MT Khayyal ◽  
W Wadie ◽  
D Weiser ◽  
H Abdel-Aziz
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate
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