scholarly journals Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865

2018 ◽  
Vol 175 (4) ◽  
pp. 708-725 ◽  
Author(s):  
Sarah A Nickolls ◽  
Rachel Gurrell ◽  
Guido van Amerongen ◽  
Juha Kammonen ◽  
Lishuang Cao ◽  
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Keyword(s):  
Gabaa Receptor ◽  
Clinical Profile ◽  
Allosteric Modulator ◽  
The Novel ◽  
Positive Allosteric Modulator

Efficacy and side effects of baclofen and the novel GABAB receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction

2018 ◽  
Vol 235 (7) ◽  
pp. 1955-1965 ◽  
Author(s):  
Valentina Vengeliene ◽  
Tatiane T. Takahashi ◽  
Olga A. Dravolina ◽  
Irina Belozertseva ◽  
Edwin Zvartau ◽  
...  
Keyword(s):  
Side Effects ◽  
Animal Models ◽  
Gabab Receptor ◽  
Cocaine Addiction ◽  
Allosteric Modulator ◽  
The Novel ◽  
Positive Allosteric Modulator

Characterization of the Novel Positive Allosteric Modulator, LY2119620, at the Muscarinic M2and M4Receptors

2014 ◽  
Vol 86 (1) ◽  
pp. 106-115 ◽  
Author(s):  
Carrie H. Croy ◽  
Douglas A. Schober ◽  
Hongling Xiao ◽  
Anne Quets ◽  
Arthur Christopoulos ◽  
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Keyword(s):  
Allosteric Modulator ◽  
The Novel ◽  
Positive Allosteric Modulator

S100. Efficacy and Safety of Brexanolone IV Across Phase 2/3 Studies: A First-In-Class GABAA Receptor Positive Allosteric Modulator for Postpartum Depression

2018 ◽  
Vol 83 (9) ◽  
pp. S385-S386 ◽  
Author(s):  
Samantha Meltzer-Brody ◽  
Stephen Kanes ◽  
Robert Riesenberg ◽  
C. Neill Epperson ◽  
Kristina Deligiannidis ◽  
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Keyword(s):  
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Gabaa Receptor ◽  
Allosteric Modulator ◽  
Phase 2 ◽  
Efficacy And Safety ◽  
Positive Allosteric Modulator

scholarly journals Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

2020 ◽  
Vol 181 ◽  
pp. 108333
Author(s):  
Alison L. Althaus ◽  
Michael A. Ackley ◽  
Gabriel M. Belfort ◽  
Steven M. Gee ◽  
Jing Dai ◽  
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Keyword(s):  
Gabaa Receptor ◽  
Allosteric Modulator ◽  
Neuroactive Steroid ◽  
Positive Allosteric Modulator

scholarly journals A novel positive allosteric modulator of the GABAA receptor: the action of (+)-ROD188

2000 ◽  
Vol 131 (4) ◽  
pp. 843-850 ◽  
Author(s):  
Urs Thomet ◽  
Roland Baur ◽  
Rodolphe Razet ◽  
Robert H Dodd ◽  
Roman Furtmüller ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator
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