scholarly journals Mast cells mediate early neutrophil recruitment and exhibit anti-inflammatory propertiesviathe formyl peptide receptor 2/lipoxin A4receptor

2017 ◽  
Vol 174 (14) ◽  
pp. 2393-2408 ◽  
Author(s):  
Ellen L Hughes ◽  
Felix Becker ◽  
Roderick J Flower ◽  
Julia C Buckingham ◽  
Felicity N E Gavins
Keyword(s):  
Mast Cells ◽  
Neutrophil Recruitment ◽  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Formyl Peptide ◽  
Anti Inflammatory

Dual modulation of formyl peptide receptor 2 by aspirin‐triggered lipoxin contributes to its anti‐inflammatory activity

2020 ◽  
Vol 34 (5) ◽  
pp. 6920-6933 ◽  
Author(s):  
Yunjun Ge ◽  
Shuo Zhang ◽  
Junlin Wang ◽  
Fangbo Xia ◽  
Jian‐Bo Wan ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Formyl Peptide ◽  
Anti Inflammatory

scholarly journals Evidence for an Anti-Inflammatory Loop Centered on Polymorphonuclear Leukocyte Formyl Peptide Receptor 2/Lipoxin A4Receptor and Operative in the Inflamed Microvasculature

2011 ◽  
Vol 186 (8) ◽  
pp. 4905-4914 ◽  
Author(s):  
Vincenzo Brancaleone ◽  
Jesmond Dalli ◽  
Stefania Bena ◽  
Roderick J. Flower ◽  
Giuseppe Cirino ◽  
...  
Keyword(s):  
Polymorphonuclear Leukocyte ◽  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Formyl Peptide ◽  
Anti Inflammatory

scholarly journals A New Staphylococcal Anti-Inflammatory Protein That Antagonizes the Formyl Peptide Receptor-Like 1

2006 ◽  
Vol 177 (11) ◽  
pp. 8017-8026 ◽  
Author(s):  
Cristina Prat ◽  
Jovanka Bestebroer ◽  
Carla J. C. de Haas ◽  
Jos A. G. van Strijp ◽  
Kok P. M. van Kessel
Keyword(s):  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Inflammatory Protein ◽  
Formyl Peptide ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

2010 ◽  
Vol 184 (5) ◽  
pp. 2611-2619 ◽  
Author(s):  
Neil Dufton ◽  
Robert Hannon ◽  
Vincenzo Brancaleone ◽  
Jesmond Dalli ◽  
Hetal B. Patel ◽  
...  
Keyword(s):  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Specific Effects ◽  
Formyl Peptide ◽  
Experimental Inflammation ◽  
Anti Inflammatory

scholarly journals Lipoxin Receptors

2007 ◽  
Vol 7 ◽  
pp. 1393-1412 ◽  
Author(s):  
Mario Romano ◽  
Irene Recchia ◽  
Antonio Recchiuti
Keyword(s):  
Current Knowledge ◽  
Cell Types ◽  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
The Family ◽  
Pathophysiological Role ◽  
Formyl Peptide ◽  
Anti Inflammatory ◽  
Main Components

Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti-inflammatory properties, LXA4and LXB4being the main components of this series. LXs are generated by cooperation between 5-lipoxygenase (LO) and 12- or 15-LO during cell-cell interactions or by single cell types. LX epimers at carbon 15, the 15-epi-LXs, are formed by aspirin-acetylated cyclooxygenase-2 (COX-2) in cooperation with 5-LO. 15-epi-LXA4is also termed aspirin-triggered LX (ATL).In vivostudies with stable LX and ATL analogs have established that these eicosanoids possess potent anti-inflammatory activities. A LXA4receptor has been cloned. It belongs to the family of chemotactic receptors and clusters with formyl peptide receptors on chromosome 19. Therefore, it was initially denominated formyl peptide receptor like 1 (FPRL1). This receptor binds with high affinity and stereoselectivity LXA4and ATL. It also recognizes a variety of peptides, synthetic, endogenously generated, or disease associated, but with lower affinity compared to LXA4. For this reason, this receptor has been renamed ALX. This review summarizes the current knowledge on ALX expression, signaling, and potential pathophysiological role. The involvement of additional recognition sites in LX bioactions is also discussed.

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