scholarly journals Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt-sensitive Dahl rats

2017 ◽  
Vol 175 (8) ◽  
pp. 1305-1317 ◽  
Author(s):  
Zi-Rui Wang ◽  
Hui-Bin Liu ◽  
Ying-Ying Sun ◽  
Qing-Qing Hu ◽  
Yu-Xia Li ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Sodium Channels ◽  
Dietary Salt ◽  
Epithelial Sodium Channels

scholarly journals Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt

2015 ◽  
Vol 172 (23) ◽  
pp. 5634-5646 ◽  
Author(s):  
Hui-Bin Liu ◽  
Jun Zhang ◽  
Ying-Ying Sun ◽  
Xin-Yuan Li ◽  
Shuai Jiang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Sodium Channels ◽  
Dietary Salt ◽  
Epithelial Sodium Channels

Abstract 072: Brain Epithelial Sodium Channels on Organum Vasculosum of the Lamina Terminalis Neurons Mediate Sympathoexcitatory Pressor Responses and Neuronal Excitation by Hypertonic NaCl

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Brian J Kinsman ◽  
Kirsteen N Browning ◽  
Sean D Stocker
Keyword(s):  
Sodium Channels ◽  
Salt Intake ◽  
Lamina Terminalis ◽  
Dietary Salt ◽  
Epithelial Sodium Channels ◽  
Adult Rats ◽  
Neuronal Excitation ◽  
Arterial Blood ◽  
Organum Vasculosum

High dietary salt intake raises cerebrospinal fluid (CSF) [Na + ] in salt sensitive subjects to elevate sympathetic nerve activity (SNA), and arterial blood pressure (ABP). This occurs through excitation of NaCl-sensitive sites in the brain, including the organum vasculosum of the lamina terminalis (OVLT). Intriguingly, intracerebroventricular (ICV) pretreatment with benzamil (a non-voltage gated Na + channel blocker) also attenuates those systemic responses to central NaCl. Thus, I hypothesized that benzamil acts on NaCl-sensitive OVLT neurons to attenuate neuronal excitation and elevated SNA and ABP in response to hypertonic NaCl. To evaluate this hypothesis, lumbar SNA and ABP were measured in anesthetized adult rats in response to ICV infusion of 0.15, 0.5, and 1.0 M NaCl with and without prior OVLT microinjection of benzamil (5nmol per 20nL). ICV infusion of NaCl produced concentration-dependent increases in lumbar SNA (0.15M: 101±3%, 0.5M: 118±3%, 1.0M: 130±9% n=4 per group, P<0.05) and mean ABP (0.15M: 1±1mmHg; 0.5M: 5±1mmHg, 1.0M: 12±2mmHg). OVLT microinjection of benzamil significantly attenuated the increase in lumbar SNA (0.15M: 100±2%, 0.5M: 108±2%, 1.0M: 115±3% n=4 per group, P<0.05) and mean ABP (0.15M: 1±0mmHg; 0.5M: 2±1mmHg, 1.0M: 6±2mmHg). In a parallel set of experiments, in vitro whole-cell recordings of OVLT neurons in slices were performed to assess whether blockade of epithelial sodium channels (ENaC) attenuated NaCl-induced excitation. Bath application of +7.5mM NaCl increase action potential (AP) discharge of OVLT neurons (n=11) from 0.46±0.16 Hz to 1.09±0.26 Hz (P<0.05). Subsequent addition of an ENaC selective concentration of benzamil (0.5μM) reversed AP discharge (0.75±0.24 Hz, P<0.05). Isotonic 0.5μM benzamil did not significantly change NaCl-sensitive OVLT neuron (n=13) AP discharge from baseline (0.54±0.14 Hz to 0.60±0.16 Hz, P>0.05). Collectively, this data indicates that elevations in CSF NaCl concentrations excite OVLT neurons via ENaC to elevate SNA and ABP.

scholarly journals Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice

Metabolism ◽  
2019 ◽  
Vol 99 ◽  
pp. 57-66 ◽  
Author(s):  
James R. Sowers ◽  
Javad Habibi ◽  
Annayya R. Aroor ◽  
Yan Yang ◽  
Guido Lastra ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Sodium Channels ◽  
Vascular Relaxation ◽  
Epithelial Sodium Channels ◽  
Female Mice ◽  
Obese Female

Medullary epithelial sodium channels (ENAC) participate in cerebral blood flow (CBF) autoregulation

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S190-S190
Author(s):  
Eugene Golanov ◽  
Heather Drummond ◽  
Jasleen Shant ◽  
Benjamin Clower ◽  
Betty Chen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sodium Channels ◽  
Epithelial Sodium Channels

scholarly journals The Plant-Derived Glucocorticoid Receptor Agonist Endiandrin A Acts as Co-Stimulator of Colonic Epithelial Sodium Channels (ENaC) via SGK-1 and MAPKs

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49426 ◽  
Author(s):  
Dana Kuntzsch ◽  
Theresa Bergann ◽  
Petra Dames ◽  
Anja Fromm ◽  
Michael Fromm ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Sodium Channels ◽  
Receptor Agonist ◽  
Epithelial Sodium Channels

scholarly journals Proteolytic Regulation of Epithelial Sodium Channels by Urokinase Plasminogen Activator

2015 ◽  
Vol 290 (9) ◽  
pp. 5241-5255 ◽  
Author(s):  
Hong-Long Ji ◽  
Runzhen Zhao ◽  
Andrey A. Komissarov ◽  
Yongchang Chang ◽  
Yongfeng Liu ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Sodium Channels ◽  
Urokinase Plasminogen Activator ◽  
Epithelial Sodium Channels

scholarly journals Ethanol Alters Alveolar Fluid Balance via Nadph Oxidase (NOX) Signaling to Epithelial Sodium Channels (ENaC) in the Lung

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54750 ◽  
Author(s):  
Charles A. Downs ◽  
David Q. Trac ◽  
Lisa H. Kreiner ◽  
Amity F. Eaton ◽  
Nicholle M. Johnson ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Sodium Channels ◽  
Fluid Balance ◽  
Epithelial Sodium Channels

scholarly journals Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells

2016 ◽  
Vol 12 (9) ◽  
pp. 1150-1154 ◽  
Author(s):  
Yang Liu ◽  
Bi-Jie Jiang ◽  
Run-Zhen Zhao ◽  
Hong-Long Ji
Keyword(s):  
Stem Cells ◽  
Sodium Channels ◽  
Epithelial Sodium Channels
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