Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models

Michael P Johnson; Mark A Muhlhauser; Eric S Nisenbaum; Rosa M A Simmons; Beth M Forster; Kelly L Knopp; Lijuan Yang; Denise Morrow; Dominic L Li; Jeffrey D Kennedy; Steven Swanson; James A Monn

doi:10.1111/bph.13740

Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models

British Journal of Pharmacology ◽

10.1111/bph.13740 ◽

2017 ◽

Vol 174 (9) ◽

pp. 822-835 ◽

Cited By ~ 11

Author(s):

Michael P Johnson ◽

Mark A Muhlhauser ◽

Eric S Nisenbaum ◽

Rosa M A Simmons ◽

Beth M Forster ◽

...

Keyword(s):

Broad Spectrum ◽

Receptor Agonist ◽

Metabotropic Glutamate ◽

Pain Models ◽

Oral Prodrug

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Effects of the metabotropic glutamate type II receptor agonist LY544344 on panic anxiety induced by cholecystokinin tetrapeptide in healthy volunteers

Pharmacopsychiatry ◽

10.1055/s-2005-918736 ◽

2005 ◽

Vol 38 (05) ◽

Author(s):

M Kellner ◽

C Muhtz ◽

K Stark ◽

A Yassouridis ◽

K Wiedemann

Keyword(s):

Healthy Volunteers ◽

Receptor Agonist ◽

Type Ii ◽

Metabotropic Glutamate

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EFFECTS OF GROUP III METABOTROPIC GLUTAMATE RECEPTOR AGONIST ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS

10.26226/morressier.59b63e3fd462b8029238916e ◽

2017 ◽

Author(s):

Masashi Honda

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Micturition Reflex ◽

Metabotropic Glutamate ◽

Anesthetized Rats ◽

Glutamate Receptor Agonist

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Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(95)00013-j ◽

1995 ◽

Vol 5 (3) ◽

pp. 223-228 ◽

Cited By ~ 30

Author(s):

S. Richard Baker ◽

John Goldsworthy ◽

Raymond C. Harden ◽

Craig R. Salhoff ◽

Darryle D. Schoepp

Keyword(s):

Glutamate Receptor ◽

Pharmacological Activity ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Enzymatic Resolution ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death

European Journal of Pharmacology ◽

10.1016/0014-2999(94)90624-6 ◽

1994 ◽

Vol 256 (1) ◽

pp. 109-112 ◽

Cited By ~ 90

Author(s):

Valeria Bruno ◽

Agata Copani ◽

Giuseppe Battaglia ◽

Rocco Raffaele ◽

Huruiko Shinozaki ◽

...

Keyword(s):

Protective Effect ◽

Glutamate Receptor ◽

Neuronal Death ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Excitotoxic Neuronal Death ◽

Glutamate Receptor Agonist

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LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

Neuroscience Letters ◽

10.1016/s0304-3940(99)00663-1 ◽

1999 ◽

Vol 273 (3) ◽

pp. 191-194 ◽

Cited By ~ 51

Author(s):

Ann Bond ◽

Nella Ragumoorthy ◽

James A. Monn ◽

Caroline A. Hicks ◽

Mark A. Ward ◽

...

Keyword(s):

Glutamate Receptor ◽

Cerebral Ischaemia ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Focal Cerebral Ischaemia ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice

European Journal of Neuroscience ◽

10.1111/ejn.13539 ◽

2017 ◽

Vol 45 (7) ◽

pp. 912-921 ◽

Cited By ~ 5

Author(s):

Thomas Boerner ◽

Alexei M. Bygrave ◽

Jingkai Chen ◽

Anushka Fernando ◽

Stephanie Jackson ◽

...

Keyword(s):

Working Memory ◽

Receptor Antagonist ◽

Glutamate Receptor ◽

Knockout Mice ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Spatial Working Memory ◽

D2 Receptor ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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Potentiation of excitatory postsynaptic potentials by a metabotropic glutamate receptor agonist (1S,3R-ACPD) in frog spinal motoneurons

Brain Research ◽

10.1016/0006-8993(95)00580-j ◽

1995 ◽

Vol 689 (2) ◽

pp. 281-288 ◽

Cited By ~ 11

Author(s):

Hiroyuki Gotani ◽

Miyuki Kuno ◽

Fusao Nakamura ◽

Shiushi Matsuura

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Excitatory Postsynaptic Potentials ◽

Spinal Motoneurons ◽

Postsynaptic Potentials ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

10.1126/science.281.5381.1349 ◽

1998 ◽

Vol 281 (5381) ◽

pp. 1349-1352 ◽

Cited By ~ 715

Author(s):

B. Moghaddam

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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A metabotropic glutamate receptor agonist DCG-IV suppresses synaptic transmission at mossy fiber pathway of the guinea pig hippocampus

Neuroscience Letters ◽

10.1016/0304-3940(96)12486-1 ◽

1996 ◽

Vol 207 (1) ◽

pp. 70-72 ◽

Cited By ~ 49

Author(s):

Masatoshi Yoshino ◽

Satsuki Sawada ◽

Chosaburo Yamamoto ◽

Haruyuki Kamiya

Keyword(s):

Guinea Pig ◽

Synaptic Transmission ◽

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Mossy Fiber ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist ◽

Mossy Fiber Pathway

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In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1

Drug Metabolism and Disposition ◽

10.1124/dmd.116.071118 ◽

2016 ◽

Vol 45 (2) ◽

pp. 137-144 ◽

Cited By ~ 4

Author(s):

Y. Anne Pak ◽

Amanda J. Long ◽

William F. Annes ◽

Jennifer W. Witcher ◽

Mary Pat Knadler ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Receptor Agonist ◽

Peptide Transporter ◽

Metabotropic Glutamate ◽

Clinical Evaluations ◽

Drug Drug Interaction ◽

Peptide Transporter 1

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