scholarly journals Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor

2016 ◽  
Vol 173 (15) ◽  
pp. 2446-2459 ◽  
Author(s):  
Mark L Bannister ◽  
Anita Alvarez‐Laviada ◽  
N Lowri Thomas ◽  
Sammy A Mason ◽  
Sharon Coleman ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Direct Action ◽  
Sarcoplasmic Reticulum Calcium ◽  
Cardiac Ryanodine Receptor

scholarly journals Effect of gadolinium on the ryanodine receptor/sarcoplasmic reticulum calcium release channel of skeletal muscle

FEBS Journal ◽  
2004 ◽  
Vol 272 (2) ◽  
pp. 464-471 ◽  
Author(s):  
Sándor Sárközi ◽  
Csaba Szegedi ◽  
Balázs Lukács ◽  
Michel Ronjat ◽  
István Jóna
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Sarcoplasmic Reticulum Calcium

scholarly journals Effect of Flecainide Derivatives on Sarcoplasmic Reticulum Ca2+ Release Confirms a Lack of Direct Action on the Cardiac Ryanodine Receptor

2016 ◽  
Vol 110 (3) ◽  
pp. 450a-451a
Author(s):  
Anita Alvarez-Laviada ◽  
Mark L. Bannister ◽  
Nia Lowri Thomas ◽  
Sammy A. Mason ◽  
Christo L. du Plessis ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Direct Action ◽  
Cardiac Ryanodine Receptor

Two novel types of calcium release from skeletal sarcoplasmic reticulum by phosphatidylinositol 4,5-bisphosphate

1999 ◽  
Vol 77 (4) ◽  
pp. 276-285 ◽  
Author(s):  
Yasushi Ohizumi ◽  
Yutaka Hirata ◽  
Atsuko Suzuki ◽  
Masaki Kobayashi
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Ruthenium Red ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Steady Level ◽  
Ryanodine Receptor 1 ◽  
Sarcoplasmic Reticulum Calcium

In both the heavy and light fractions of fragmented sarcoplasmic reticulum (SR) vesicles from the fast skeletal muscle, about 27 min after beginning the active Ca2+ uptake, the extravesicular Ca2+ concentration suddenly increased to reach a steady level (delayed Ca2+ release). Phosphatidylinositol 4,5-bisphosphate (PIP2) not only shortened the time to delayed Ca2+ release but also induced prompt Ca2+ release from the heavy fraction of SR. Delayed Ca2+ release and prompt Ca2+ release stimulated by 100 µM PIP2 were not modified by ruthenium red. PIP2 (>0.1 µM) markedly accelerated the rate of 45Ca2+ efflux from SR vesicles in a concentration-dependent manner. The PIP2-induced 45Ca2+ efflux was potentiated by ruthenium red but profoundly inhibited by La3+. The concentration-response curve for Ca2+ or Mg2+ in PIP2-induced 45Ca2+ release was clearly different from that in the Ca2+-induced Ca2+ release. PIP2 caused a concentration-dependent increase in Ca2+ release from SR of chemically skinned fibers from skeletal muscle. Furthermore, [3H]ryanodine or [3H]methyl-7-bromoeudistomin D (MBED) binding to SR was increased by PIP2 in a concentration-dependent manner. These observations present the first evidence that PIP2 most likely activates two types of SR Ca2+ release channels whose properties are entirely different from those of Ca2+-induced Ca2+ release channels (the ryanodine receptor 1).Key words: phosphatidylinositol 4,5-bisphosphate, sarcoplasmic reticulum, calcium release, ryanodine receptor, ryanodine.

scholarly journals Zinc Modulates Skeletal Ryanodine Receptor Function Resulting in Altered Sarcoplasmic Reticulum Calcium Release

2016 ◽  
Vol 110 (3) ◽  
pp. 270a
Author(s):  
Gavin B. Robertson ◽  
Benedict Reilly-O'Donnell ◽  
Craig Balmforth ◽  
Samantha J. Pitt
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Receptor Function ◽  
Sarcoplasmic Reticulum Calcium
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