scholarly journals Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity

2016 ◽  
Vol 173 (14) ◽  
pp. 2208-2223 ◽  
Author(s):  
Jun Yin ◽  
Lichen Bao ◽  
Hong Tian ◽  
Qun Wang ◽  
Xiangdong Gao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Genetic Fusion ◽  
Synthetic Polypeptide ◽  
Human Fgf21

scholarly journals Pharmacokinetics and Pharmacodynamics of Clofazimine in a Mouse Model of Tuberculosis

2015 ◽  
Vol 59 (6) ◽  
pp. 3042-3051 ◽  
Author(s):  
Rosemary V. Swanson ◽  
John Adamson ◽  
Chivonne Moodley ◽  
Bongani Ngcobo ◽  
Nicole C. Ammerman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Bactericidal Activity ◽  
Tuberculosis Treatment ◽  
Pharmacokinetic Parameters ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Content Type ◽  
Optimal Dosing ◽  
Drug Concentrations ◽  
Dosing Regimens ◽  
Dose Dependent

ABSTRACTThe antileprosy drug clofazimine has shown potential for shortening tuberculosis treatment; however, the current dosing of the drug is not evidence based, and the optimal dosing is unknown. Our objective was to conduct a preclinical evaluation of the pharmacokinetics and pharmacodynamics of clofazimine in the mouse model of tuberculosis, with the goal of providing useful information on dosing for future studies. Pharmacokinetic parameters were evaluated in infected and uninfected BALB/c mice. Pharmacodynamic parameters were evaluated inMycobacterium tuberculosis-infected mice that were treated for 12 weeks with one of six different clofazimine dosing regimens, i.e., doses of 6.25, 12.5, and 25 mg/kg of body weight/day and 3 regimens with loading doses. Clofazimine progressively accumulated in the lungs, livers, and spleens of the mice, reaching levels of greater than 50 μg/g in all tissues by 4 weeks of administration, while serum drug levels remained low at 1 to 2 μg/ml. Elimination of clofazimine was extremely slow, and the half-life was dependent on the duration of drug administration. Clofazimine exhibited dose-dependent tissue and serum concentrations. At any dose, clofazimine did not have bactericidal activity during the first 2 weeks of administration but subsequently demonstrated potent, dose-independent bactericidal activity. The antituberculosis activity of clofazimine was dependent on neither the dose administered nor the drug concentrations in the tissues, suggesting that much lower doses could be effectively used for tuberculosis treatment.

Regenerating myofibers in tibialis anterior muscles of young ‘MDX’ mice

1987 ◽  
Vol 45 ◽  
pp. 726-727
Author(s):  
H. D. Geissinge ◽  
L.D. Rhodes
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Tibialis Anterior ◽  
Physiological Activity ◽  
Mdx Mice ◽  
Mode Of Inheritance

A recently discovered mouse model (‘mdx’) for muscular dystrophy in man may be of considerable interest, since the disease in ‘mdx’ mice is inherited by the same mode of inheritance (X-linked) as the human Duchenne (DMD) muscular dystrophy. Unlike DMD, which results in a situation in which the continual muscle destruction cannot keep up with abortive regenerative attempts of the musculature, and the sufferers of the disease die early, the disease in ‘mdx’ mice appears to be transient, and the mice do not die as a result of it. In fact, it has been reported that the severely damaged Tibialis anterior (TA) muscles of ‘mdx’ mice seem to display exceptionally good regenerative powers at 4-6 weeks, so much so, that these muscles are able to regenerate spontaneously up to their previous levels of physiological activity.

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer

Pharmacokinetics and pharmacodynamics of meperidine in healthy horses

2020 ◽  
Vol 47 (6) ◽  
pp. 855.e11-855.e12
Author(s):  
H. Trenholme ◽  
A. Hanafi ◽  
R. Reed ◽  
D. Sakai ◽  
C. Ryan ◽  
...  
Keyword(s):  
Pharmacokinetics And Pharmacodynamics
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