scholarly journals Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists

2016 ◽  
Vol 173 (8) ◽  
pp. 1393-1403 ◽  
Author(s):  
David Winpenny ◽  
Mellissa Clark ◽  
Darren Cawkill
Keyword(s):  
Drug Discovery ◽  
Opioid Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Receptor Agonists ◽  
Μ Opioid Receptor ◽  
Opioid Receptor Agonists

Transformation of μ-opioid receptor agonists into biologically potent μ-opioid receptor antagonists

2007 ◽  
Vol 15 (3) ◽  
pp. 1237-1251 ◽  
Author(s):  
Tingyou Li ◽  
Yunden Jinsmaa ◽  
Masahiro Nedachi ◽  
Anna Miyazaki ◽  
Yuko Tsuda ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Antagonists ◽  
Receptor Agonists ◽  
Opioid Receptor Antagonists ◽  
Μ Opioid Receptor ◽  
Opioid Receptor Agonists

scholarly journals Absence of G-protein activation by μ-opioid receptor agonists in the spinal cord of μ-opioid receptor knockout mice

1999 ◽  
Vol 126 (2) ◽  
pp. 451-456 ◽  
Author(s):  
Minoru Narita ◽  
Hirokazu Mizoguchi ◽  
Michiko Narita ◽  
Ichiro Sora ◽  
George R Uhl ◽  
...  
Keyword(s):  
Spinal Cord ◽  
G Protein ◽  
Opioid Receptor ◽  
Knockout Mice ◽  
Protein Activation ◽  
Receptor Agonists ◽  
G Protein Activation ◽  
Μ Opioid Receptor ◽  
Opioid Receptor Agonists

Involvement of β-arrestin-2 in modulation of the spinal antinociception induced by μ-opioid receptor agonists in the mouse

2003 ◽  
Vol 346 (1-2) ◽  
pp. 13-16 ◽  
Author(s):  
Masahiro Ohsawa ◽  
Hirokazu Mizoguchi ◽  
Minoru Narita ◽  
Hiroshi Nagase ◽  
Nae J. Dun ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonists ◽  
Μ Opioid Receptor ◽  
Opioid Receptor Agonists

scholarly journals μ-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD

2009 ◽  
Vol 77 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Hui Zheng ◽  
Yan Zeng ◽  
Xiaoxiao Zhang ◽  
Ji Chu ◽  
Horace H. Loh ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonists ◽  
Μ Opioid Receptor ◽  
Opioid Receptor Agonists
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