scholarly journals Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension

2015 ◽  
Vol 172 (12) ◽  
pp. 3159-3176 ◽  
Author(s):  
R Hernanz ◽  
S Martínez-Revelles ◽  
R Palacios ◽  
A Martín ◽  
V Cachofeiro ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Toll Like Receptor ◽  
Vascular Remodelling ◽  
Toll Like Receptor 4 ◽  
Induced Hypertension

scholarly journals Toll‐Like Receptor 4 Contributes to Hypertension and Endothelial Dysfunction Produced By Angiotensin II

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Vijay Palvia ◽  
Chelsea Pyle ◽  
Erin Mezzetti ◽  
Xunsheng Chen ◽  
Sean Didion
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

K V 1.3 channels are novel determinants of macrophage‐dependent endothelial dysfunction in angiotensin II‐induced hypertension in mice

2021 ◽  
Vol 178 (8) ◽  
pp. 1836-1854
Author(s):  
Miguel A. Olivencia ◽  
Marta Martínez‐Casales ◽  
Diego A. Peraza ◽  
Ana B. García‐Redondo ◽  
Gema Mondéjar‐Parreño ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Induced Hypertension

scholarly journals Expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/Tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary diseases and their relationships with pulmonary vascular remodelling

2018 ◽  
Vol 64 (4) ◽  
pp. 361-367 ◽  
Author(s):  
Wen-Cheng Yu ◽  
Jin-Peng Cong ◽  
Li-Yun Mi
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Control Group ◽  
Chronic Obstructive ◽  
Toll Like Receptor ◽  
Vascular Remodelling ◽  
Toll Like Receptor 4 ◽  
Metalloproteinase 9 ◽  
Pulmonary Vascular Remodelling

SUMMARY OBJECTIVE: This study aims at investigating the expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/ tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary disease (COPD) and their relationships with pulmonary vascular remodelling (PVR). METHODS: 60 para-tumour tissues were divided into the COPD group and the control group (n=30); the inflammations, pulmonary artery wall area/total artery area (WA%), and wall thickness/vascular outer diameter (WT%) were compared. The expressions of TLR-4, MMP-9/TIMP-1, and PCNA in pulmonary vascular smooth muscle cells were detected, and their relationships with PVR were then analysed. RESULTS: The inflammations (1.6±0.8), WA% (44.0±6.4), and WT% (27.3±3.3) in the COPD group were higher than in the control group (0.3±0.5, 26.1±2.8, 15.6±1.8), and the expressions of TLR-4 (31.4±147) and MMP-9/TIMP-1 (2.2±2.6) were increased compared to the control group (4.7±4.5, 1.9±12). Correlation analysis: TLR-4 and MMP-9/TIMP-1 were positively correlated with the inflammations (r=0.18, P<0.01), WA% (r=0.68, P<0.01), and WT% (r=0.73, P<0.01), as well as positively correlated with the expression of PCNA (r=0.44, P<0.01); the upregulation of TLR-4 was positively correlated with the expressions of MMP-9 and TIMP-1. CONCLUSIONS: The upregulation of TLR-4 in the pulmonary arterial smooth muscle cells of COPD patients could promote the inflammations and the MMP-9 expression, thus causing abnormal degradation of extracellular matrix, so it played an important role in the process of PVR.

scholarly journals Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II‐infused rats

2019 ◽  
Vol 104 (6) ◽  
pp. 946-956 ◽  
Author(s):  
Jian Wei ◽  
Lian Xu ◽  
Ya‐Nan Du ◽  
Xiao‐Feng Tang ◽  
Mao‐Qing Ye ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Thoracic Aorta ◽  
Membrane Raft ◽  
Vascular Remodelling ◽  
Redox Signalling

scholarly journals Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin

2015 ◽  
Vol 309 (9) ◽  
pp. E767-E776 ◽  
Author(s):  
Jeong-a Kim ◽  
Hyun-Ju Jang ◽  
Daniel H. Hwang
Keyword(s):  
Endoplasmic Reticulum ◽  
Endothelial Dysfunction ◽  
Er Stress ◽  
Saturated Fatty Acids ◽  
Chow Diet ◽  
Toll Like Receptor ◽  
Proinflammatory Response ◽  
Toll Like Receptor 4 ◽  
Aortic Endothelial Cells ◽  
Vasodilator Action

Impairment of vasodilator action of insulin is associated with endothelial dysfunction and insulin resistance. Activation of Toll-like receptor 4 (TLR4) induces proinflammatory response and endoplasmic reticulum (ER) stress. Saturated fatty acids (SFA) activate TLR4, which induces ER stress and endothelial dysfunction. Therefore, we determined whether TLR4-mediated ER stress is an obligatory step mediating SFA-induced endothelial dysfunction. Palmitate stimulated proinflammatory responses and ER stress, and this was suppressed by knockdown of TLR4 in primary human aortic endothelial cells (HAEC). Next, we examined the role of TLR4 in vasodilatory responses in intact vessels isolated from wild-type (WT, C57BL/6) and TLR4-KO mice after feeding high-fat (HFD) or normal chow diet (NCD) for 12 wk. Arterioles isolated from HFD WT mice exhibited impaired insulin-stimulated vasodilation compared with arterioles isolated from NCD WT mice. Deficiency of TLR4 was protective from HFD-induced impairment of insulin-stimulated vasodilation. There were no differences in acetylcholine (Ach)- or sodium nitroprusside (SNP)-stimulated vasodilation between the two groups. Furthermore, we examined whether ER stress is involved in SFA-induced impairment of vasodilator actions of insulin. Infusion of palmitate showed the impairment of vasodilatory response to insulin, which was ameliorated by coinfusion with tauroursodeoxycholic acid (TUDCA), an ER stress suppressor. Taken together, the results suggest that TLR4-induced ER stress may be an obligatory step mediating the SFA-mediated endothelial dysfunction.

scholarly journals Sonic Hedgehog Carried by Microparticles Corrects Angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72861 ◽  
Author(s):  
Vannina González Marrachelli ◽  
Maria Letizia Mastronardi ◽  
Mamadou Sarr ◽  
Raffaella Soleti ◽  
Daniela Leonetti ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Sonic Hedgehog ◽  
Induced Hypertension

EPA:DHA 6:1 prevents angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase- and COX-derived oxidative stress

2017 ◽  
Vol 40 (12) ◽  
pp. 966-975 ◽  
Author(s):  
Zahid Rasul Niazi ◽  
Grazielle C Silva ◽  
Thais Porto Ribeiro ◽  
Antonio J León-González ◽  
Mohamad Kassem ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Nadph Oxidase ◽  
Induced Hypertension

scholarly journals Inhibition of STAT3 activation mediated by toll‐like receptor 4 attenuates angiotensin II‐induced renal fibrosis and dysfunction

2019 ◽  
Vol 176 (14) ◽  
pp. 2627-2641 ◽  
Author(s):  
Zheng Xu ◽  
Chunpeng Zou ◽  
Weihui Yu ◽  
Sujing Xu ◽  
Lan Huang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renal Fibrosis ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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