scholarly journals Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits

2015 ◽  
Vol 172 (5) ◽  
pp. 1237-1249 ◽  
Author(s):  
Yasuhiro Nakagami ◽  
Kayoko Masuda ◽  
Emiko Hatano ◽  
Tatsuya Inoue ◽  
Takuya Matsuyama ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Transformation Products ◽  
Blood Retinal Barrier ◽  
Barrier Permeability

Microbial Transformation of Isosteviol Lactone and Evaluation of the Transformation Products on Androgen Response Element

2008 ◽  
Vol 71 (4) ◽  
pp. 602-607 ◽  
Author(s):  
Bo-Hon Chou ◽  
Li-Ming Yang ◽  
Shwu-Fen Chang ◽  
Feng-Lin Hsu ◽  
Chia-Hsin Lo ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Transformation Products ◽  
Response Element ◽  
Androgen Response Element

High-Throughput Identification of Microbial Transformation Products of Organic Micropollutants

2010 ◽  
Vol 44 (17) ◽  
pp. 6621-6627 ◽  
Author(s):  
Damian E. Helbling ◽  
Juliane Hollender ◽  
Hans-Peter E. Kohler ◽  
Heinz Singer ◽  
Kathrin Fenner
Keyword(s):  
High Throughput ◽  
Microbial Transformation ◽  
Transformation Products ◽  
Organic Micropollutants

Microbial Transformations of Azaarenes in Creosote-Contaminated Soil and Ground Water: Laboratory and Field Studies

1988 ◽  
Vol 20 (11-12) ◽  
pp. 17-23 ◽  
Author(s):  
Wilfred E. Pereira ◽  
Colleen E. Rostad ◽  
David M. Updegraff ◽  
Jon L. Bennett
Keyword(s):  
Ground Water ◽  
Contaminated Soil ◽  
Isotope Labeling ◽  
Microbial Transformation ◽  
Wood Preservative ◽  
Transformation Products ◽  
Gas Chromatography Mass Spectrometry ◽  
Experimental Conditions ◽  
Hydroxylation Reaction ◽  
Contaminated Aquifers

Azaarenes or aromatic nitrogen heterocycles are a class of compounds found in wood-preservative wastes containing creosote. The fate and movement of these compounds in contaminated aquifers is not well understood. Water-quality studies in an aquifer contaminated with creosote near Pensacola, Florida, indicated that ground water was contaminated with several azaarenes and their oxygenated and alkylated derivatives, suggesting that these oxygenated compounds may be products of microbial transformation reactions. Accordingly, laboratory studies were designed to investigate the fate of these compounds. Under aerobic conditions, soil pseudomonads isolated from creosote-contaminated soil converted quinoline to 2(lH)quinolinone that subsequently was degraded to unknown products. A methanogenic consortium isolated from an anaerobic sewage digestor, in presence of ground-water and creosote-contaminated soil, converted quinoline, isoquinoline, and 4-methylquinoline to their respective oxygenated analogs. In addition, N-, C-, and O-methylated analogs of oxygenated azaarenes were identified by gas chromatography-mass spectrometry (GC-MS) in anaerobic cultures. Under the experimental conditions, 2-methylquinoline was biorefractory. Presence of similar biotransformation products in anaerobic cultures and contaminated ground water from the Pensacola site provided further evidence that these compounds indeed were microbial transformation products. Stable isotope labeling studies indicated that the source of the oxygen atom for this hydroxylation reaction under aerobic and anaerobic conditions was water. A mechanism was proposed for this hydroxylation reaction. Whereas parent azaarenes are biodegradable in both anaerobic and aerobic zones, oxygenated and alkylated analogs are more biorefractory and, hence, persistent in anaerobic zones of contaminated aquifers.

Inhibitory effects of bucillamine on increased blood-retinal barrier permeability in streptozotocin-induced diabetic rats

2002 ◽  
Vol 25 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Taiichi Hikichi ◽  
Fumihiko Mori ◽  
Masao Nakamura ◽  
Naomi Shishido ◽  
Mai Sasaki ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Inhibitory Effects ◽  
Blood Retinal Barrier ◽  
Barrier Permeability

Fluorophotometric Evaluation of Blood-Retinal Barrier Permeability in Patients with Essential Hypertension

2004 ◽  
Vol 218 (3) ◽  
pp. 180-184 ◽  
Author(s):  
A. Pogrzebielski ◽  
W. Lubaszewski ◽  
M. Starzycka ◽  
K. Kawecka-Jaszcz
Keyword(s):  
Essential Hypertension ◽  
Blood Retinal Barrier ◽  
Barrier Permeability

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

1993 ◽  
Vol 25 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Keith Green ◽  
Tracey Slagle ◽  
Manuel J. Chaknis ◽  
Lisa Cheeks ◽  
Stanley Chang
Keyword(s):  
Blood Retinal Barrier ◽  
Barrier Permeability ◽  
Rabbit Blood
Sign in / Sign up

Export Citation Format

Share Document