scholarly journals Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10

2014 ◽  
Vol 171 (18) ◽  
pp. 4155-4176 ◽  
Author(s):  
Wakako Fujita ◽  
Ivone Gomes ◽  
Lakshmi A Devi
Keyword(s):  
Opioid Receptor ◽  
Therapeutic Targets ◽  
Receptor Heteromers ◽  
Novel Therapeutic

scholarly journals Opioid receptor heteromers in analgesia

2012 ◽  
Vol 14 ◽  
Author(s):  
Cristina M. Costantino ◽  
Ivone Gomes ◽  
Steven D. Stockton ◽  
Maribel P. Lim ◽  
Lakshmi A. Devi
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Therapeutic Targets ◽  
Endogenous Opioid ◽  
Chronic Morphine ◽  
Receptor Complexes ◽  
Receptor Signalling ◽  
Receptor Heteromers ◽  
The Usa ◽  
Abused Drugs

Opiates such as morphine and fentanyl, a major class of analgesics used in the clinical management of pain, exert their effects through the activation of opioid receptors. Opioids are among the most commonly prescribed and frequently abused drugs in the USA; however, the prolonged use of opiates often leads to the development of tolerance and addiction. Although blockade of opioid receptors with antagonists such as naltrexone and naloxone can lessen addictive impulses and facilitate recovery from overdose, systemic disruption of endogenous opioid receptor signalling through the use of these antagonistic drugs can have severe side effects. In the light of these challenges, current efforts have focused on identifying new therapeutic targets that selectively and specifically modulate opioid receptor signalling and function so as to achieve analgesia without the adverse effects associated with chronic opiate use. We have previously reported that opioid receptors interact with each other to form heteromeric complexes and that these interactions affect morphine signalling. Since chronic morphine administration leads to an enhanced level of these heteromers, these opioid receptor heteromeric complexes represent novel therapeutic targets for the treatment of pain and opiate addiction. In this review, we discuss the role of heteromeric opioid receptor complexes with a focus on mu opioid receptor (MOR) and delta opioid receptor (DOR) heteromers. We also highlight the evidence for altered pharmacological properties of opioid ligands and changes in ligand function resulting from the heteromer formation.

Identification of novel therapeutic targets in SDH-mutated cancers: tracing dysfunction

2017 ◽  
Author(s):  
Charlotte Lussey-Lepoutre ◽  
Kate E R Hollinshead ◽  
Christian Ludwig ◽  
Melanie Menara ◽  
Aurelie Morin ◽  
...  
Keyword(s):  
Therapeutic Targets ◽  
Novel Therapeutic

Oxidized Haemoglobin–Driven Endothelial Dysfunction and Immune Cell Activation: Novel Therapeutic Targets for Atherosclerosis

2013 ◽  
Vol 20 (37) ◽  
pp. 4806-4814 ◽  
Author(s):  
Brigitta Buttari ◽  
Elisabetta Profumo ◽  
Rita Businaro ◽  
Luciano Saso ◽  
Raffaele Capoano ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cell Activation ◽  
Immune Cell ◽  
Therapeutic Targets ◽  
Immune Cell Activation ◽  
Novel Therapeutic

Recent Development in Identification of Potential Novel Therapeutic Targets Against Trypanosomatids

2016 ◽  
Vol 16 (20) ◽  
pp. 2303-2315 ◽  
Author(s):  
Rajender Kumar ◽  
Parvati Sharma ◽  
Deepak Kumar Gaur ◽  
Shikha Jain
Keyword(s):  
Therapeutic Targets ◽  
Novel Therapeutic
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