scholarly journals Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats

2013 ◽  
Vol 169 (5) ◽  
pp. 1048-1057 ◽  
Author(s):  
Nattayaporn Apaijai ◽  
Hiranya Pintana ◽  
Siriporn C Chattipakorn ◽  
Nipon Chattipakorn
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Function ◽  
Mitochondrial Function ◽  
Insulin Resistant

Protective effects of garlic extract on cardiac function, heart rate variability, and cardiac mitochondria in obese insulin-resistant rats

2013 ◽  
Vol 53 (3) ◽  
pp. 919-928 ◽  
Author(s):  
Luerat Supakul ◽  
Hiranya Pintana ◽  
Nattayaporn Apaijai ◽  
Siriporn Chattipakorn ◽  
Krekwit Shinlapawittayatorn ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Function ◽  
Garlic Extract ◽  
Protective Effects ◽  
Cardiac Mitochondria ◽  
Insulin Resistant

scholarly journals Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats

2017 ◽  
Vol 232 (2) ◽  
pp. 189-204 ◽  
Author(s):  
Pongpan Tanajak ◽  
Hiranya Pintana ◽  
Natthaphat Siri-Angkul ◽  
Juthamas Khamseekaew ◽  
Nattayaporn Apaijai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Function ◽  
Cardiac Dysfunction ◽  
Metabolic Regulation ◽  
Left Ventricular ◽  
Lv Function ◽  
Insulin Resistant

Long-term high-fat diet (HFD) consumption causes cardiac dysfunction. Although calorie restriction (CR) has been shown to be useful in obesity, we hypothesized that combined CR with dipeptidyl peptidase-4 (DPP-4) inhibitor provides greater efficacy than monotherapy in attenuating cardiac dysfunction and metabolic impairment in HFD-induced obese-insulin resistant rats. Thirty male Wistar rats were divided into 2 groups to be fed on either a normal diet (ND, n = 6) or a HFD (n = 24) for 12 weeks. Then, HFD rats were divided into 4 subgroups (n = 6/subgroup) to receive just the vehicle, CR diet (60% of mean energy intake and changed to ND), vildagliptin (3 mg/kg/day) or combined CR and vildagliptin for 4 weeks. Metabolic parameters, heart rate variability (HRV), cardiac mitochondrial function, left ventricular (LV) and fibroblast growth factor (FGF) 21 signaling pathway were determined. Rats on a HFD developed insulin and FGF21 resistance, oxidative stress, cardiac mitochondrial dysfunction and impaired LV function. Rats on CR alone showed both decreased body weight and visceral fat accumulation, whereas vildagliptin did not alter these parameters. Rats in CR, vildagliptin and CR plus vildagliptin subgroups had improved insulin sensitivity and oxidative stress. However, vildagliptin improved heart rate variability (HRV), cardiac mitochondrial function and LV function better than the CR. Chronic HFD consumption leads to obese-insulin resistance and FGF21 resistance. Although CR is effective in improving metabolic regulation, vildagliptin provides greater efficacy in preventing cardiac dysfunction by improving anti-apoptosis and FGF21 signaling pathways and attenuating cardiac mitochondrial dysfunction in obese-insulin-resistant rats.

Effects of PPARγ agonist on heart rate variability and cardiac mitochondrial function in obese-insulin resistant rats

2015 ◽  
Vol 201 ◽  
pp. 121-122 ◽  
Author(s):  
Noppamas Pipatpiboon ◽  
Jirapas Sripetchwandee ◽  
Siriporn C. Chattipakorn ◽  
Nipon Chattipakorn
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Mitochondrial Function ◽  
Insulin Resistant ◽  
Pparγ Agonist

Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability—The ARIC study

1995 ◽  
Vol 76 (12) ◽  
pp. 906-912 ◽  
Author(s):  
Duanping Liao ◽  
Ralph W. Barnes ◽  
Lloyd E. Chambless ◽  
Ross J. Simpson ◽  
Paul Sorlie ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sex Differences ◽  
Spectral Analysis ◽  
Cardiac Function ◽  
Aric Study

scholarly journals Autonomic Dysfunction Predicts Early Cardiac Affection in Patients with Systemic Sclerosis

2010 ◽  
Vol 3 ◽  
pp. CMAMD.S4940 ◽  
Author(s):  
Khaled M. Othman ◽  
Naglaa Youssef Assaf ◽  
Hanan Mohamed Farouk ◽  
Iman M. Aly Hassan
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Systemic Sclerosis ◽  
Cardiac Function ◽  
Cardiac Involvement ◽  
Holter Monitoring ◽  
Significant Negative Correlation ◽  
Skin Thickness ◽  
Noninvasive Methods ◽  
Premature Ventricular Contractions

Objective To detect the early preclinical alterations in cardiac autonomic control as well as altered cardiac function in systemic sclerosis (SSc) patients and their relevance to the clinical features of the disease using noninvasive methods. Methods 30 SSc patients and 15 healthy controls matched for age and sex underwent clinical examination, serological analysis, and echocardiographic assessment including Doppler flow imaging to evaluate cardiac function, and 24-hour Holter monitoring analyzed for arrhythmia and heart rate variability (HRV) in the time and frequency domains. Results The trans-mitral Doppler of early to atrial wave (E/A) ratio was reversed in five patients (16.6%) and the tricuspid E/A ratio was reversed in 10 patients (33.3%). Holter analysis for SSc patients revealed an increased prevalence of premature ventricular contractions (PVC) ≥ 10/h ( P = 0.02), supra-ventricular tachycardias (SVTs) ( P = 0.2), and total PVC count ( P = 0.0000). Highly significant ( P = 0.000) impairment in all HRV parameters was demonstrated in the SSc patients. Total skin thickness score (TSS), Raynaud's phenomenon and anti-scleroderma 70 (anti-SCL70) showed significant positive correlations with all arrhythmia parameters, while showing a significant negative correlation with the impaired ventricular diastolic function and various HRV parameters. No correlation was found between arrhythmia and HRV parameters and disease duration, disease type, or presence of anti-centromere antibodies. Conclusion Low heart rate variability, increased TSS and the presence of anti-SCL70 are correlated with preclinical cardiac involvement in SSc patients and may predict the likelihood of malignant arrhythmia and sudden cardiac death. Therefore, noninvasive HRV evaluation before clinical cardiac involvement in these patients might be beneficial when added to the clinical and laboratory assessments in detecting high-risk patients, and may allow for implementation of preventive measures and initiation of appropriate therapy early in the course of the disease.

Chronic Istaroxime Improves Cardiac Function and Heart Rate Variability in Cardiomyopathic Hamsters

2011 ◽  
Vol 25 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Pietro Lo Giudice ◽  
Giovan Giuseppe Mattera ◽  
Jean-Pierre Gagnol ◽  
Franco Borsini
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Function ◽  
Cardiomyopathic Hamsters

scholarly journals Heart rate variability and cardiac function in heart failure rats treated with allogeneic mesenchymal stem cells (547.21)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Sharon Morais ◽  
Renata Lataro ◽  
Carlos Alberto Silva ◽  
Luciano Oliveira ◽  
Eduardo Carvalho ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function

Abstract WP377: Heart Rate Variability Biofeedback Improves Cardiac Autonomic Function in Patients With Acute Ischaemic Stroke: A Randomized Controlled Study

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Timo Siepmann ◽  
Paulin Ohle ◽  
Erik Simon ◽  
Annahita Sedghi ◽  
Lars P Pallesen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Spectral Analysis ◽  
Cardiac Function ◽  
Functional Outcomes ◽  
Stroke Unit ◽  
Autonomic Function ◽  
Cardiac Autonomic Function ◽  
Autonomic Symptoms ◽  
Stroke Unit Care

Introduction: In patients with acute ischaemic stroke (AIS) dysregulation of cardiac function with decreased heart rate variability (HRV) due to impaired integrity of the autonomic nervous system is a frequent complication which is associated with increased mortality and worsening of clinical outcome. HRV biofeedback has previously been suggested to improve cardiac autonomic function by increasing parasympathetic tone. Hypothesis: We hypothesized that HRV biofeedback can be used to complement stroke unit care and alleviate autonomic cardiac dysfunction following AIS. Methods: We randomly allocated patients with AIS to either receive 9 sessions of HRV (n=24) or sham (n=24) biofeedback in addition to standard stroke unit care. These patients underwent detailed assessment of autonomic cardiac function including analysis of HRV via standard deviation of NN intervals (SDNN) and spectral analysis. Furthermore, we assessed vasomotor and sudomotor autonomic function, severity of autonomic symptoms and neurological and functional outcomes. Results: We included 48 patients (19 females, ages 65±14 years, baseline NIHSS 2.2 ± 2.2, mean ± standard deviation). Patients who had undergone HRV biofeedback displayed improved cardiac function compared to baseline (SDNN 72.6 ± 52.4 ms vs. 45.5 ± 34.7 ms, p<0.01) which was not seen in those who received sham biofeedback (p=ns). Similar changes were seen on spectral analysis measures of parasympathetic function (p<0.01). Improvement of autonomic cardiac function following HRV biofeedback was paralleled by decreased severity of autonomic symptoms (p<0.05). Contrasting our observation of an increase in predominantly parasympathetic parameters such as CVNN, sympathetic measures of sudomotor and vasomotor function remained unchanged in both groups (p=ns). Neurological and functional outcomes were unchanged immediately post intervention, however 3-month follow up is yet to be completed. Discussion: HRV biofeedback can modulate autonomic cardiac function post AIS to increase HRV and alleviate autonomic symptoms which might be beneficial in facilitating recovery from functional impairment. This seems to be mediated by a predominantly parasympathetic mechanism of action.

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