scholarly journals Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling

2013 ◽  
Vol 168 (7) ◽  
pp. 1758-1770 ◽  
Author(s):  
Bing Sun ◽  
Jing Xiao ◽  
Xiao-Bo Sun ◽  
Ying Wu
Keyword(s):  
Cardiac Dysfunction ◽  
Oestrogen Receptor ◽  
Receptor Activation ◽  
Insight Into

Structural aspects of agonism and antagonism in the oestrogen receptor

2000 ◽  
Vol 28 (4) ◽  
pp. 396-400 ◽  
Author(s):  
A. C. W. Pike ◽  
A. M. Brzozowski ◽  
J. Walton ◽  
R. E. Hubbard ◽  
T. Bonn ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Oestrogen Receptor ◽  
Three Dimensional ◽  
Receptor Activation ◽  
Structural Basis ◽  
Diverse Range ◽  
Antagonist Action ◽  
Receptor Agonists And Antagonists ◽  
Insight Into ◽  
Structural Aspects

We have determined the three-dimensional structures of both α- and β-forms of the ligand-binding domain of the oestrogen receptor (ER) in complexes with a range of receptor agonists and antagonists. Here, we summarize how these structures provide both an understanding of the ER's distinctive pharmacophore and a rationale for its ability to bind a diverse range of chemically distinct compounds. In addition, these studies provide a unique insight into the mechanisms that underlie receptor activation, as well as providing a structural basis for the antagonist action of molecules, such as raloxifene.

scholarly journals A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

2010 ◽  
Vol 79 (2) ◽  
pp. 262-269 ◽  
Author(s):  
Kamonchanok Sansuk ◽  
Xavier Deupi ◽  
Ivan R. Torrecillas ◽  
Aldo Jongejan ◽  
Saskia Nijmeijer ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Activation ◽  
Transmembrane Domains ◽  
G Protein Coupled Receptor ◽  
Structural Insight ◽  
G Protein Coupled ◽  
Insight Into

scholarly journals Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Wataru Shihoya ◽  
Tamaki Izume ◽  
Asuka Inoue ◽  
Keitaro Yamashita ◽  
Francois Marie Ngako Kadji ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Receptor Activation ◽  
Partial Activation ◽  
Mechanistic Insight ◽  
Etb Receptor ◽  
Insight Into

scholarly journals Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation

2013 ◽  
Vol 591 (17) ◽  
pp. 4223-4235 ◽  
Author(s):  
G. Cristina Brailoiu ◽  
Khalid Benamar ◽  
Jeffrey B. Arterburn ◽  
Erhe Gao ◽  
Joseph E. Rabinowitz ◽  
...  
Keyword(s):  
G Protein ◽  
Oestrogen Receptor ◽  
Vagal Tone ◽  
Receptor Activation ◽  
Cardiac Vagal Tone ◽  
G Protein Coupled

scholarly journals Inhibiting Insulin-Mediated β 2 -Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction

Circulation ◽  
2017 ◽  
Vol 135 (1) ◽  
pp. 73-88 ◽  
Author(s):  
Qingtong Wang ◽  
Yongming Liu ◽  
Qin Fu ◽  
Bing Xu ◽  
Yuan Zhang ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Adrenergic Receptor ◽  
Receptor Activation

scholarly journals The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation

2015 ◽  
Vol 29 (8) ◽  
pp. 785-790 ◽  
Author(s):  
Kai Xu ◽  
Olav Olsen ◽  
Dorothea Tzvetkova-Robev ◽  
Marc Tessier-Lavigne ◽  
Dimitar B. Nikolov
Keyword(s):  
Crystal Structure ◽  
Amyloid Precursor Protein ◽  
Death Receptor ◽  
Receptor Activation ◽  
Precursor Protein ◽  
Insight Into
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