scholarly journals Noradrenaline stimulates cell proliferation by suppressing potassium channels via Gi/o-protein-coupled α1B-adrenoceptors in human osteoblasts

2013 ◽  
Vol 168 (5) ◽  
pp. 1230-1239 ◽  
Author(s):  
D Kodama ◽  
A Togari
Keyword(s):  
Cell Proliferation ◽  
Potassium Channels ◽  
Human Osteoblasts

scholarly journals Calcium-Activated Potassium Channels BK and IK1 Are Functionally Expressed in Human Gliomas but Do Not Regulate Cell Proliferation

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12304 ◽  
Author(s):  
Iskandar F. Abdullaev ◽  
Alena Rudkouskaya ◽  
Alexander A. Mongin ◽  
Yu-Hung Kuo
Keyword(s):  
Cell Proliferation ◽  
Potassium Channels ◽  
Human Gliomas ◽  
Calcium Activated Potassium Channels

Observations on Biological Effects of Carbon-13, Based on the Effects of 13C-Testosterone on Growth of Human Osteoblasts, Human Aortic Endothelial Cells, and Human Umbilical Vein Endothelial Cells in Vitro

2021 ◽  
Author(s):  
Mengqi Zhang ◽  
Wenning Yang ◽  
Xinchen Wu ◽  
Tengfei Zhang
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Isotope Effect ◽  
Umbilical Vein ◽  
Biological Effects ◽  
Bioactive Compound ◽  
Human Osteoblasts ◽  
Aortic Endothelial Cells ◽  
Umbilical Vein Endothelial Cells

Abstract Despite the increasing knowledge of biological isotope effect, comprehensive understanding of heavy isotope effect in the biological contexts has remained far less than expectation. The present study investigated the carbon isotope effect of 13C enriched testosterone on human cells. It was among the rare studies on carbon isotope effect of bioactive compound. Human osteoblasts, human aortic endothelial cells, and human umbilical vein endothelial cells were cultured in vitro and treated with testosterone and 13C enriched testosterone (13C/12C:6.7%). The impacts of physiological to pharmacological concentrations (10-10-10-5mol/L) of the bioactive compound were taken into account. The cell proliferation activities were measured using MTS assay. The levels of alkaline phosphatase and osteocalcin in osteoblasts were tested. Our results established that 13C enriched testosterone exhibited different biological effects from testosterone. At the concentrations of 10-10mol/L and 10-5mol/L, there were significant differences in prompting cell proliferation between testosterone and 13C enriched testosterone. At physiological concentrations, testosterone prompted proliferations of the three kinds of cells; whereas, 13C enriched testosterone did not prompt the cell proliferation, and its effects were not concentration dependent. At supraphysiological concentration (10-5mol/L), testosterone had the trend of inhibiting cell growth; whereas, 13C enriched testosterone had the trend of prompting cell growth. 13C enriched testosterone significantly enhanced osteocalcin secretion in human osteoblasts at supraphysiological concentration. These findings challenged the common view of growth retardation effect of heavy isotope, which imply that biological isotope effects are worthy of further study. The potential applications of 13C enriched compound were discussed.

Effect of celecoxib on Ca2+ movement and cell proliferation in human osteoblasts

2004 ◽  
Vol 67 (6) ◽  
pp. 1123-1130 ◽  
Author(s):  
Jue-L. Wang ◽  
Ko-L. Lin ◽  
Jin-S. Chen ◽  
Yih-C. Lu ◽  
Bang-P. Jiann ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Human Osteoblasts

Upregulation of ATP-sensitive potassium channels for estrogen-mediated cell proliferation in human uterine leiomyoma cells

2008 ◽  
Vol 24 (5) ◽  
pp. 250-256 ◽  
Author(s):  
Sung-Hee Park ◽  
Sabarish Ramachandran ◽  
Sang-Hoon Kwon ◽  
Soon-Do Cha ◽  
Eul Won Seo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Potassium Channels ◽  
Uterine Leiomyoma

Cell proliferation, potassium channels, polyamines and their interactions: a mini review

Amino Acids ◽  
2013 ◽  
Vol 46 (3) ◽  
pp. 681-688 ◽  
Author(s):  
Thomas M. Weiger ◽  
Anton Hermann
Keyword(s):  
Cell Proliferation ◽  
Potassium Channels
Sign in / Sign up

Export Citation Format

Share Document