scholarly journals Myxoid glioneuronal tumor, PDGFRA p.K385L‐mutant, arising in midbrain tectum with multifocal CSF dissemination

2021 ◽  
Author(s):  
B. K. Kleinschmidt‐DeMasters ◽  
Jason Chiang ◽  
Andrew M. Donson ◽  
Thomas Borges ◽  
Ahmed Gilani
Keyword(s):  
Glioneuronal Tumor ◽  
Csf Dissemination

Glioneuronal tumor with neuropil-like islands

2000 ◽  
Vol 31 (11) ◽  
pp. 1435-1438
Author(s):  
Richard A. Prayson ◽  
Caroline M. Abramovich
Keyword(s):  
Glioneuronal Tumor

scholarly journals Diffuse leptomeningeal glioneuronal tumor with high-grade features masquerading as tubercular meningitis—a case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Sameer Peer ◽  
Vivek Murumkar ◽  
Karthik Kulanthaivelu ◽  
Chandrajit Prasad ◽  
Shilpa Rao ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Histopathological Examination ◽  
Glioneuronal Tumor ◽  
Communicating Hydrocephalus ◽  
High Grade ◽  
Endemic Region ◽  
Tubercular Meningitis ◽  
Leptomeningeal Enhancement ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

Abstract Background Diffuse leptomeningeal glioneuronal tumor (DLGNT) has been recently described in the literature. The complete neuroimaging spectrum and histopathological characteristics of this entity are yet to be elucidated. In an endemic region, diffuse leptomeningeal enhancement on neuroimaging with associated communicating hydrocephalus is usually suggestive of infective meningitis and the patients are started on empirical anti-microbial therapy. However, it is important to consider other differential diagnosis of leptomeningeal enhancement in such cases, particularly if the clinical condition does not improve on anti-microbial therapy. An early diagnosis of a neoplastic etiology may be of particular importance as the treatment regimens vary considerably depending on the underlying disease condition. Case presentation In this case report, we describe a case of DLGNT with high-grade histopathological features which was initially managed as tubercular meningitis based on the initial neuroimaging findings. Due to worsening of the clinical course and subsequent imaging findings at follow-up, a diagnosis of DLGNT was considered and subsequently proven to be DLGNT with features of anaplasia on histopathological examination of leptomeningeal biopsy specimen. Conclusion This case highlights the importance of recognizing certain subtle finding on MRI which may help in an early diagnosis of DLGNT which is crucial for appropriate treatment.

scholarly journals Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle: A Case of Relapse Treated with Proton Beam Therapy

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 903
Author(s):  
Antonella Cacchione ◽  
Angela Mastronuzzi ◽  
Andrea Carai ◽  
Giovanna Stefania Colafati ◽  
Francesca Diomedi-Camassei ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Proton Beam ◽  
Fourth Ventricle ◽  
Histopathological Examination ◽  
Local Level ◽  
Proton Beam Therapy ◽  
Disease Recurrence ◽  
Glioneuronal Tumor ◽  
First Case ◽  
Cystic Component

Rosette-forming glioneuronal tumors (RGNTs) are rare, grade I, central nervous system (CNS) tumors typically localized to the fourth ventricle. We describe a 9-year-old girl with dizziness and occipital headache. A magnetic resonance imaging (MRI) revealed a large hypodense posterior fossa mass lesion in relation to the vermis, with cystic component. Surgical resection of the tumor was performed. A RGNT diagnosis was made at the histopathological examination. During follow-up, the patient experienced a first relapse, which was again surgically removed. Eight months after, MRI documented a second recurrence at the local level. She was a candidate for the proton beam therapy (PBT) program. Three years after the end of PBT, the patient had no evidence of disease recurrence. This report underlines that, although RGNTs are commonly associated with an indolent course, they may have the potential for aggressive behavior, suggesting the need for treatment in addition to surgery. Controversy exists in the literature regarding effective management of RGNTs. Chemotherapy and radiation are used as adjuvant therapy, but their efficacy management has not been adequately described in the literature. This is the first case report published in which PBT was proposed for adjuvant therapy in place of chemotherapy in RGNT relapse.

Recurrent intracranial solitary fibrous tumor with cerebrospinal fluid dissemination

2004 ◽  
Vol 101 (6) ◽  
pp. 1045-1048 ◽  
Author(s):  
Katsuyoshi Miyashita ◽  
Yutaka Hayashi ◽  
Hironori Fujisawa ◽  
Mitsuhiro Hasegawa ◽  
Junkoh Yamashita
Keyword(s):  
Cerebrospinal Fluid ◽  
Malignant Transformation ◽  
Solitary Fibrous Tumor ◽  
S100 Protein ◽  
Spinal Tumors ◽  
Content Type ◽  
Csf Dissemination ◽  
Fibrous Tumor ◽  
Fine Print ◽  
Mib 1

✓ Solitary fibrous tumor (SFT) is a benign and rare neoplasm. To date, only 37 patients with intracranial SFTs have been reported. Although a number of the tumors were recurrent and some later underwent malignant transformation, none of these lesions progressed to cerebrospinal fluid (CSF) dissemination. In this paper the authors report a case of SFT in which the lesion recurred several times and ultimately was disseminated by the CSF. The patient was a 63-year-old woman with multiple intracranial and spinal tumors. Fifteen years before this presentation, at the age of 48 she had been hospitalized for resection of a falcotentorial tumor. During the ensuing 15 years she underwent multiple surgeries and sessions of radiation therapy for recurrent lesions. The exclusive location of her tumors in the subarachnoid space at the end of this 15-year period indicate CSF dissemination of the tumor. The tumor that was resected when the patient was 48 years old and the latest resected lesion were analyzed by performing immunohistological CD34, epithelial membrane antigen, vimentin, S100 protein, and reticulin staining, and determining the MIB-1 labeling index (LI). Most of the results were identical, and both tumors were diagnosed as SFT according to a staining pattern that showed a strong and diffuse positive reaction for CD34. Nevertheless, the authors noted that the MIB-1 LI increased from less than 1% in the original tumor to 13% in the latest tumor. The increased proliferation of MIB-1 indicates that the malignant transformation could have occurred during tumor recurrence with CSF dissemination.

Papillary glioneuronal tumor: A clinicopathological and immunohistochemical study of two cases

2006 ◽  
Vol 26 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Li Chen ◽  
Yue-Shan Piao ◽  
Qing-Zhong Xu ◽  
Xiao-Ping Yang ◽  
Hong Yang ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Glioneuronal Tumor ◽  
Papillary Glioneuronal Tumor

scholarly journals Cerebellar liponeurocytoma with atypical histological features – a rare example of a glioneuronal tumor

2017 ◽  
Vol 3 ◽  
pp. 227-234 ◽  
Author(s):  
Blanka Hermann ◽  
Michal Woznica ◽  
Wojciech Kloc ◽  
Piotr Borkowski ◽  
Witold Libionka ◽  
...  
Keyword(s):  
Glioneuronal Tumor ◽  
Histological Features ◽  
Cerebellar Liponeurocytoma

Papillary glioneuronal tumor: a case report and review of the literature

2006 ◽  
Vol 37 (7) ◽  
pp. 914-918 ◽  
Author(s):  
Daniel C. Dim ◽  
Daniel C. Lingamfelter ◽  
Eugenio M. Taboada ◽  
Russell M. Fiorella
Keyword(s):  
Case Report ◽  
Glioneuronal Tumor ◽  
Review Of The Literature ◽  
Papillary Glioneuronal Tumor

Rosette-forming glioneuronal tumor of the fourth ventricle

2012 ◽  
Vol 39 (2) ◽  
pp. 129-130 ◽  
Author(s):  
Bo Yin ◽  
Li Liu ◽  
Xing-rong Chen ◽  
Ke Li ◽  
Dao-ying Geng
Keyword(s):  
Fourth Ventricle ◽  
Glioneuronal Tumor
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