scholarly journals Ependymoma‐like tumor with mesenchymal differentiation harboring C11orf95 ‐ NCOA1 / 2 or ‐ RELA fusion: A hitherto unclassified tumor related to ependymoma

2021 ◽  
Author(s):  
Ran Tomomasa ◽  
Yasuhito Arai ◽  
Reika Kawabata‐Iwakawa ◽  
Kohei Fukuoka ◽  
Yoshiko Nakano ◽  
...  
Keyword(s):  
Mesenchymal Differentiation

scholarly journals Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes

2021 ◽  
Vol 296 ◽  
pp. 100488
Author(s):  
Ewa Stypulkowski ◽  
Qiang Feng ◽  
Ivor Joseph ◽  
Victoria Farrell ◽  
Juan Flores ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Mesenchymal Differentiation

scholarly journals Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2721
Author(s):  
Tingting Qin ◽  
Shiting Li ◽  
Leanne E. Henry ◽  
Siyu Liu ◽  
Maureen A. Sartor
Keyword(s):  
Head And Neck ◽  
Stromal Cells ◽  
Clinical Characteristics ◽  
Molecular Subtypes ◽  
Squamous Cell Carcinomas ◽  
Head And Neck Cancers ◽  
Molecular Signatures ◽  
Tumor Subtypes ◽  
Mesenchymal Differentiation ◽  
High Incidence

Until recently, research on the molecular signatures of Human papillomavirus (HPV)-associated head and neck cancers mainly focused on their differences with respect to HPV-negative head and neck squamous cell carcinomas (HNSCCs). However, given the continuing high incidence level of HPV-related HNSCC, the time is ripe to characterize the heterogeneity that exists within these cancers. Here, we review research thus far on HPV-positive HNSCC molecular subtypes, and their relationship with clinical characteristics and HPV integration into the host genome. Different omics data including host transcriptomics and epigenomics, as well as HPV characteristics, can provide complementary viewpoints. Keratinization, mesenchymal differentiation, immune signatures, stromal cells and oxidoreductive processes all play important roles.

Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis

2003 ◽  
Vol 90 (2) ◽  
pp. 372-377 ◽  
Author(s):  
Frederic Amant ◽  
Veerle Vloeberghs ◽  
Heidi Woestenborghs ◽  
Philippe Moerman ◽  
Ignace Vergote
Keyword(s):  
Mesenchymal Differentiation ◽  
Ovarian Carcinosarcoma

scholarly journals Myogenic dedifferentiation is associated with poor outcomes in retroperitoneal dedifferentiated liposarcomas

Rare Tumors ◽  
2021 ◽  
Vol 13 ◽  
pp. 203636132098665
Author(s):  
Garcia-Ortega Dorian Yarih ◽  
Caro-Sánchez Claudia HS ◽  
Alvarez-Cano Alethia ◽  
Alvarez-Bojorquez Mario ◽  
Melgarejo-Estefan Emmanuel ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Myogenic Differentiation ◽  
Smooth Muscle Actin ◽  
Locally Advanced ◽  
Distant Recurrence ◽  
Differentiation Markers ◽  
Surgical Morbidity ◽  
Mesenchymal Differentiation ◽  
Heterogenous Group ◽  
Poor Outcomes

Sarcomas are a heterogenous group of malignant tumors with origin or mesenchymal differentiation, they comprise 1–2% of all solid tumors. Retroperitoneum is the second most frequent site affected. Prognosis is worse compared to the limbs, with a 5y OS of 36–58%, and 50–60% patients will relapse. Dedifferentiated liposarcomas (ddLPS) are more aggressive, it is known that presence of a de-differentiated component increases the probability of distant recurrence and lowers OS. There is little information about the specific impact of each type of de-differentiation. To determine if the presence of myogenic differentiation markers in DDLPS is an adverse prognostic factor. A retrospective, observational, analytic cohort study was performed. Cases identified from the electronic clinical files from the National Cancer Institute in Mexico City, we included cases from January 1st 2005 to December 31st 2016. We correlated the presence of expression of myogenic markers (Smooth muscle actin, Calponin, H-caldesmon, Desmin and Myogenin) in the dedifferentiated component of DDLPS with overall survival and surgical outcomes. One hundred and forty-three cases were analyzed. Eighty-two were liposarcomas, and 38 had a dedifferentiated component. Of these 38 cases, 21(55.3%) were males and, 17(44.7%) were females. Median age was 54.1(27–79) years, median tumor size was 28 cm (13–56). Most patients had locally advanced disease: 32(84.2%) were in stage IIIB. 2.6% had metastatic disease and 5(13.2%) had stage Ib at diagnosis. Myogenic marker expression was found in 18.4% of cases; these patients had a worse median survival than cases with no myogenic expression: 18 months (95% CI 15.4–20.5) vs 32 months (95% CI 21.8–42.1) p = 0.01, we also found a relation with higher postoperative morbidity in these cases ( p = 0.045). The presence of myogenic differentiation markers might be associated with a worse prognosis, in our series it corelated with worse OS, however it is not a common event. Relation with surgical morbidity is to be analyzed in further studies.

scholarly journals p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

PLoS ONE ◽  
2008 ◽  
Vol 3 (11) ◽  
pp. e3707 ◽  
Author(s):  
Alina Molchadsky ◽  
Igor Shats ◽  
Naomi Goldfinger ◽  
Meirav Pevsner-Fischer ◽  
Melissa Olson ◽  
...  
Keyword(s):  
Cell Fate ◽  
Dependent Manner ◽  
Mesenchymal Differentiation ◽  
A Cell

scholarly journals E1a induces the expression of epithelial characteristics.

1994 ◽  
Vol 127 (4) ◽  
pp. 1085-1096 ◽  
Author(s):  
S M Frisch
Keyword(s):  
Tumor Cells ◽  
Present Report ◽  
Human Tumor ◽  
Cell Types ◽  
Suppressor Gene ◽  
Specific Cell ◽  
Human Tumor Cells ◽  
Mammalian Embryo ◽  
Adenovirus E1a ◽  
Mesenchymal Differentiation

Cells closely resembling epithelia constitute the first specific cell type in a mammalian embryo. Many other cell types emerge via epithelial-mesenchymal differentiation. The transcription factors and signal transduction pathways involved in this differentiation are being elucidated. I have previously reported (Frisch, 1991) that adenovirus E1a is a tumor suppressor gene in certain human cell lines. In the present report, I demonstrate that E1a expression caused diverse human tumor cells (rhabdomyosarcoma, fibrosarcoma, melanoma, osteosarcoma) and fibroblasts to assume at least two of the following epithelial characteristics: (a) epithelioid morphology; (b) epithelial-type intercellular adhesion proteins localized to newly formed junctional complexes; (c) keratin-containing intermediate filaments; and (d) down-regulation of non-epithelial genes. E1a thus appeared to partially convert diverse human tumor cells into an epithelial phenotype. This provides a new system for molecular analysis of epithelial-mesenchymal interconversions. This effect may also contribute to E1a's tumor suppression activity, possibly through sensitization to anoikis (Frisch, S.M., and H. Francis, 1994. J. Cell Biol. 124:619-626).

scholarly journals Matrix Nanopatterning Regulates Mesenchymal Differentiation through Focal Adhesion Size and Distribution According to Cell Fate

Biomimetics ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 43 ◽  
Author(s):  
Ignasi Casanellas ◽  
Anna Lagunas ◽  
Yolanda Vida ◽  
Ezequiel Pérez-Inestrosa ◽  
José A. Andrades ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Fate ◽  
Focal Adhesion ◽  
Membrane Receptors ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Local Surface ◽  
Mesenchymal Differentiation ◽  
Cell Substrate ◽  
Arginine Glycine Aspartic Acid

Extracellular matrix remodeling plays a pivotal role during mesenchyme patterning into different lineages. Tension exerted from cell membrane receptors bound to extracellular matrix ligands is transmitted by the cytoskeleton to the cell nucleus inducing gene expression. Here, we used dendrimer-based arginine–glycine–aspartic acid (RGD) uneven nanopatterns, which allow the control of local surface adhesiveness at the nanoscale, to unveil the adhesive requirements of mesenchymal tenogenic and osteogenic commitments. Cell response was found to depend on the tension resulting from cell–substrate interactions, which affects nuclear morphology and is regulated by focal adhesion size and distribution.

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