scholarly journals The use and limitations of single‐cell mass cytometry for studying human microglia function

2020 ◽  
Vol 30 (6) ◽  
pp. 1178-1191 ◽  
Author(s):  
Camila Fernández‐Zapata ◽  
Julia K. H. Leman ◽  
Josef Priller ◽  
Chotima Böttcher
Keyword(s):  
Single Cell ◽  
Cell Mass ◽  
Mass Cytometry ◽  
Human Microglia

scholarly journals Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

2018 ◽  
Vol 22 (1) ◽  
pp. 78-90 ◽  
Author(s):  
Chotima Böttcher ◽  
◽  
Stephan Schlickeiser ◽  
Marjolein A. M. Sneeboer ◽  
Desiree Kunkel ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Mass ◽  
Mass Cytometry ◽  
Regional Heterogeneity ◽  
Human Microglia

scholarly journals Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Christos Nikolaou ◽  
Kerstin Muehle ◽  
Stephan Schlickeiser ◽  
Alberto Sada Japp ◽  
Nadine Matzmohr ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Mass ◽  
High Dimensional ◽  
Mass Cytometry ◽  
Hematopoietic System

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry

2019 ◽  
Vol 200 ◽  
pp. 24-30 ◽  
Author(s):  
Min Sun Shin ◽  
Kristina Yim ◽  
Kevin Moon ◽  
Hong-Jai Park ◽  
Subhasis Mohanty ◽  
...  
Keyword(s):  
T Cells ◽  
Single Cell ◽  
Cd8 T Cells ◽  
Cell Mass ◽  
High Dimensional ◽  
Mass Cytometry

scholarly journals Scalable Conjugation and Characterization of Immunoglobulins with Stable Mass Isotope Reporters for Single-Cell Mass Cytometry Analysis

2019 ◽  
pp. 55-81 ◽  
Author(s):  
Felix J. Hartmann ◽  
Erin F. Simonds ◽  
Nora Vivanco ◽  
Trevor Bruce ◽  
Luciene Borges ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Mass ◽  
Mass Cytometry

scholarly journals Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice

2014 ◽  
Vol 111 (46) ◽  
pp. 16466-16471 ◽  
Author(s):  
Michael Mingueneau ◽  
Smita Krishnaswamy ◽  
Matthew H. Spitzer ◽  
Sean C. Bendall ◽  
Erica L. Stone ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Mass ◽  
Nod Mice ◽  
Mass Cytometry ◽  
Tcr Signaling ◽  
Erk Activation

scholarly journals CBIO-19. DISSECTING THE MULTICELLULAR ECOSYSTEM OF HUMAN GLIOBLASTOMA TUMORS USING SINGLE CELL MASS CYTOMETRY

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi39-vi39
Author(s):  
Nalin Leelatian ◽  
Justine Sinnaeve ◽  
Bret Mobley ◽  
Kyle Weaver ◽  
Reid Thompson ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Mass ◽  
Mass Cytometry ◽  
Human Glioblastoma

scholarly journals Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage

2020 ◽  
Vol 6 (11) ◽  
pp. eaay5352 ◽  
Author(s):  
Fiorella Carla Grandi ◽  
Reema Baskar ◽  
Piera Smeriglio ◽  
Shravani Murkherjee ◽  
Pier Francesco Indelli ◽  
...  
Keyword(s):  
Single Cell ◽  
Interleukin 1 ◽  
Cell Mass ◽  
Tumor Necrosis Factor Receptor ◽  
Mass Cytometry ◽  
Therapeutic Approaches ◽  
Osteoarthritic Cartilage ◽  
Regenerative Cells ◽  
Cell Subpopulations ◽  
D Cells

Aging or injury leads to degradation of the cartilage matrix and the development of osteoarthritis (OA). Because of a paucity of single-cell studies of OA cartilage, little is known about the interpatient variability in its cellular composition and, more importantly, about the cell subpopulations that drive the disease. Here, we profiled healthy and OA cartilage samples using mass cytometry to establish a single-cell atlas, revealing distinct chondrocyte progenitor and inflammation-modulating subpopulations. These rare populations include an inflammation-amplifying (Inf-A) population, marked by interleukin-1 receptor 1 and tumor necrosis factor receptor II, whose inhibition decreased inflammation, and an inflammation-dampening (Inf-D) population, marked by CD24, which is resistant to inflammation. We devised a pharmacological strategy targeting Inf-A and Inf-D cells that significantly decreased inflammation in OA chondrocytes. Using our atlas, we stratified patients with OA in three groups that are distinguished by the relative proportions of inflammatory to regenerative cells, making it possible to devise precision therapeutic approaches.

scholarly journals Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells

2019 ◽  
Vol 37 (3) ◽  
pp. 259-266 ◽  
Author(s):  
Zinaida Good ◽  
Luciene Borges ◽  
Nora Vivanco Gonzalez ◽  
Bita Sahaf ◽  
Nikolay Samusik ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Single Cell ◽  
Cell Mass ◽  
Mass Cytometry ◽  
Cell Memory
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