scholarly journals Recent advances on the molecular pathogenesis of prion diseases

2019 ◽  
Vol 29 (2) ◽  
pp. 245-247
Author(s):  
Markus Glatzel ◽  
Christina J. Sigurdson
Keyword(s):  
Prion Diseases ◽  
Molecular Pathogenesis ◽  
Recent Advances

The molecular pathogenesis of HIV-1 associated nephropathy: recent advances

2011 ◽  
Vol 89 (5) ◽  
pp. 429-436 ◽  
Author(s):  
Natalia Papeta ◽  
Roel Sterken ◽  
Krzysztof Kiryluk ◽  
Robert Kalyesubula ◽  
Ali G. Gharavi
Keyword(s):  
Molecular Pathogenesis ◽  
Recent Advances ◽  
Hiv 1

scholarly journals TSE Diagnostics: Recent Advances in Immunoassaying Prions

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Anja Lukan ◽  
Tanja Vranac ◽  
Vladka Čurin Šerbec
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodegenerative Diseases ◽  
Brain Tissue ◽  
Prion Diseases ◽  
Cellular Prion Protein ◽  
Transmissible Spongiform Encephalopathies ◽  
Post Mortem ◽  
Definite Diagnosis ◽  
Spongiform Encephalopathies ◽  
Recent Advances

Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals. They are believed to be the consequence of the conversion of the cellular prion protein to its aggregation-prone,β-sheet-rich isoform, named prion. Definite diagnosis of TSEs is determinedpost mortem. For this purpose, immunoassays for analyzing brain tissue have been developed. However, the ultimate goal of TSE diagnostics is anante mortemtest, which would be sensitive enough to detect prions in body fluids, that is, in blood, cerebrospinal fluid, or urine. Such a test would be of paramount importance also for screening of asymptomatic carriers of the disease with the aim of increasing food, drugs, and blood-derived products safety. In the present paper, we have reviewed recent advances in the development of immunoassays for the detection of prions.

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