scholarly journals TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia

2018 ◽  
Vol 28 (6) ◽  
pp. 806-821 ◽  
Author(s):  
Parul H. Kothari ◽  
Grant R. Kolar ◽  
Joanna C. Jen ◽  
Rula Hajj-Ali ◽  
Paula Bertram ◽  
...  
Keyword(s):  
Human Brain ◽  
Normal Human Brain ◽  
Normal Human

Aldosteronotrophic and Corticosteronotrophic Substances in Normal Human Brain

Pharmacology ◽  
1960 ◽  
Vol 3 (2) ◽  
pp. 113-116 ◽  
Author(s):  
K. Kovács ◽  
Margrit A. Dávid ◽  
P. Weisz
Keyword(s):  
Human Brain ◽  
Normal Human Brain ◽  
Normal Human

scholarly journals Quantitative lithium magnetic resonance spectroscopy in the normal human brain on a 3 T clinical scanner

2011 ◽  
Vol 66 (4) ◽  
pp. 945-949 ◽  
Author(s):  
Fiona E. Smith ◽  
David A. Cousins ◽  
Peter E. Thelwall ◽  
I. Nicol Ferrier ◽  
Andrew M. Blamire
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Human Brain ◽  
Resonance Spectroscopy ◽  
Normal Human Brain ◽  
Normal Human ◽  
Clinical Scanner

Age-related changes in proton T1 values of normal human brain

1995 ◽  
Vol 5 (1) ◽  
pp. 43-48 ◽  
Author(s):  
R. Grant Steen ◽  
Suzanne A. Gronemeyer ◽  
June S. Taylor
Keyword(s):  
Human Brain ◽  
Normal Human Brain ◽  
Age Related ◽  
Normal Human ◽  
Age Related Changes

Radiosurgical Lesions in the Normal Human Brain 17 Years after Gamma Knife Capsulotomy

Neurosurgery ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 396-402 ◽  
Author(s):  
Lars Kihlström ◽  
Tomas Hindmarsh ◽  
Ingmar Lax ◽  
Bodo Lippitz ◽  
Per Mindus ◽  
...  
Keyword(s):  
Human Brain ◽  
Gamma Knife ◽  
Normal Human Brain ◽  
Normal Human

scholarly journals Ferumoxytol enhanced resting state fMRI and relative cerebral blood volume mapping in normal human brain

NeuroImage ◽  
2013 ◽  
Vol 83 ◽  
pp. 200-209 ◽  
Author(s):  
Helen D'Arceuil ◽  
Alexandre Coimbra ◽  
Pamela Triano ◽  
Margaret Dougherty ◽  
Julie Mello ◽  
...  
Keyword(s):  
Human Brain ◽  
Blood Volume ◽  
Resting State ◽  
Cerebral Blood Volume ◽  
Resting State Fmri ◽  
Normal Human Brain ◽  
Relative Cerebral Blood Volume ◽  
Normal Human

Longitudinal Stability of Personality

1992 ◽  
Vol 70 (2) ◽  
pp. 483-498 ◽  
Author(s):  
David D. Smith
Keyword(s):  
Human Brain ◽  
Predictive Power ◽  
Total Variance ◽  
Global Dynamics ◽  
Longitudinal Stability ◽  
Normal Human Brain ◽  
Adult Personality ◽  
Normal Human ◽  
Personality Theories ◽  
Over Time

Estimates of the longitudinal stability of the normal adult personality decrease with increase in the length of the assessment-reassessment interval over which stability is measured, regardless of the method employed. This randomness in the evolution of personality is attributed to the inherent indeterminacy of the global dynamics of the normal human brain. The predictive power of theories of personality is fundamentally constrained. Explanatory personality theories should not be evaluated in terms of the proportion of the total variance that they predict over time but rather on the proportion of the predictable variance they account for.

scholarly journals Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2520 ◽  
Author(s):  
Anchal Sharma ◽  
Asgar Hussain Ansari ◽  
Renu Kumari ◽  
Rajesh Pandey ◽  
Rakhshinda Rehman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Corpus Callosum ◽  
Human Brain ◽  
Frontal Cortex ◽  
Oxidative Stress Marker ◽  
Somatic Variation ◽  
Single Nucleotide ◽  
Normal Human Brain ◽  
Normal Human ◽  
The Brain

Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base variations measuring up to 0.48% of the total variations. Interestingly, about 64% of these somatic variations in the brain are expected to lead to non-synonymous changes, and as much as 87% of these represent G:C>T:A transversion events. Further, the transversion events in the brain were mostly found in the frontal cortex, whereas the corpus callosum from the same individuals harbors the reference genotype. We found a significantly higher amount of 8-OHdG (oxidative stress marker) in the frontal cortex compared to the corpus callosum of the same subjects (p<0.01), correlating with the higher G:C>T:A transversions in the cortex. We found significant enrichment for axon guidance and related pathways for genes harbouring somatic variations. This could represent either a directed selection of genetic variations in these pathways or increased susceptibility of some loci towards oxidative stress. This study highlights that oxidative stress possibly influence single nucleotide somatic variations in normal human brain.

Sign in / Sign up

Export Citation Format

Share Document