scholarly journals Cerebral amyloidoma is characterized by B-cell clonality and a stable clinical course

2017 ◽  
Vol 28 (2) ◽  
pp. 234-239 ◽  
Author(s):  
Katharina Heß ◽  
Jan Purrucker ◽  
Ute Hegenbart ◽  
Benjamin Brokinkel ◽  
Rouven Berndt ◽  
...  
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Cell Clonality ◽  
Cerebral Amyloidoma

scholarly journals Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hidekazu Nishikii ◽  
Naoki Kurita ◽  
Atsushi Shinagawa ◽  
Tatsuhiro Sakamoto ◽  
Manabu Kusakabe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
B Cell ◽  
Clinical Remission ◽  
Clinical Course ◽  
Lymphocytic Leukemia ◽  
Hematopoietic Stem ◽  
Cell Clonality

A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. Clinical remission was achieved, while B-cell clonality remained. Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (fludarabine and 2-Gy total body irradiation). However, autologous hematopoietic recovery occurred within a month after the transplant. Nevertheless, B-cell clonality became undetectable at 14 days after transplant, which has been kept so for over 10 years with clinical remission. Cytogenetic analyses were repeatedly performed and demonstrated nonclonal chromosomal aberrations, although the patient did not develop any secondary malignancies. One possible explanation for the clinical course is a very short-term allogeneic immune reaction helping eradication of residual CLL cells.

Gastric MALT lymphoma (GML) after helicobacter pylori (Hp) eradication: Prognostic value of histological and molecular findings in 120 patients of a prospective multicenter trial

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 8041-8041
Author(s):  
T. Wündisch ◽  
A. Neubauer ◽  
A. Gunther ◽  
M. Stolte
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Molecular Data ◽  
Multicenter Trial ◽  
Histological Findings ◽  
Long Term Follow Up ◽  
Cell Clonality ◽  
Prospective Multicenter Trial

8041 Background: Long lasting remissions occur in most patients with localized GML after Hp eradication. Ongoing B-cell clonality and the translocation t(11;18) have been described as factors associated with no response, relapse and histological residual disease (hRD). Systematic evaluation of histological findings associated with the clinical course and molecular data has not been described yet. Methods: Detailed analysis of long term follow up data of a prospective multicenter trial including 120 patients (median follow up > 5 years) with Hp-positive stage I1E GML was performed. Histological and molecular data of biopsies from 1187 endoscopies were analyzed using a large data base. Hp-status, granulocytic-, lymphocytic infiltration and intestinal metaplasia (IM) were histologically graduated according to the Updated Sydney system. The histological findings empty lamina propria (ELP), fibrosis, lymphoid follicles (LF) and lymphoepithelial lesions and lymphoid aggregates (LA) were evaluated. Prospective molecular data concerning B-cell clonality as well as retrospective data concerning the status of the translocation t(11;18) were also collected. Results: LA and LF were more present in patients not responding towards Hp eradication [P < 0.0001]. ELP in high frequency is a positive predictor for reaching complete remission (CR) [P= <0,0001]. Fibrosis was only found in CR patients. In patients reaching a histological CR presence of LA and LF were associated with hRD and relapse [P=0.04]. LA / LF were also more prevalent in t(11;18) positive and patients with ongoing B-cell clonality. An association between ongoing monoclonality and t (11;18) was also demonstrated [p=0,012]. In 66% of patients IM was detected, it does not disappear during long term follow up after successful Hp eradication. Conclusions: Simple histological findings can help to predict the clinical course of GML after Hp eradication and are associated with known molecular data. No significant financial relationships to disclose.

scholarly journals T-Cell Lymphoma Clonality by Copy Number Variation Analysis of T-Cell Receptor Genes

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 340
Author(s):  
Ming Liang Oon ◽  
Jing Quan Lim ◽  
Bernett Lee ◽  
Sai Mun Leong ◽  
Gwyneth Shook-Ting Soon ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
T Cell Receptor ◽  
Copy Number ◽  
Nk Cell ◽  
Cell Receptor ◽  
T Cell Lymphomas ◽  
Number Variation ◽  
Diagnostic Applications ◽  
Cell Clonality

T-cell lymphomas arise from a single neoplastic clone and exhibit identical patterns of deletions in T-cell receptor (TCR) genes. Whole genome sequencing (WGS) data represent a treasure trove of information for the development of novel clinical applications. However, the use of WGS to identify clonal T-cell proliferations has not been systematically studied. In this study, based on WGS data, we identified monoclonal rearrangements (MRs) of T-cell receptors (TCR) genes using a novel segmentation algorithm and copy number computation. We evaluated the feasibility of this technique as a marker of T-cell clonality using T-cell lymphomas (TCL, n = 44) and extranodal NK/T-cell lymphomas (ENKTLs, n = 20), and identified 98% of TCLs with one or more TCR gene MRs, against 91% detected using PCR. TCR MRs were absent in all ENKTLs and NK cell lines. Sensitivity-wise, this platform is sufficiently competent, with MRs detected in the majority of samples with tumor content under 25% and it can also distinguish monoallelic from biallelic MRs. Understanding the copy number landscape of TCR using WGS data may engender new diagnostic applications in hematolymphoid pathology, which can be readily adapted to the analysis of B-cell receptor loci for B-cell clonality determination.

Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient

2021 ◽  
Vol 14 (7) ◽  
pp. e243307
Author(s):  
Orlando De Jesus ◽  
Christian Rios-Vicil ◽  
Frances M Gómez-González ◽  
Román Vélez
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Cell Lymphoma ◽  
Brain Mri ◽  
B Cell Lymphoma ◽  
Optic Chiasm ◽  
Immunocompetent Patient ◽  
Primary Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Primary lymphoma of the visual pathway is rare, especially at the chiasm. Very few cases have been reported. The lesion is frequently confused with an optic–hypothalamic glioma. A 55-year-old man was found disoriented at his home by a friend and evaluated with a brain MRI which demonstrated an expansile mass located at the optic chiasm and hypothalamus level. The principal differential was a high-grade hypothalamic glioma due to the contrast enhancement. A biopsy of the chiasmal lesion was performed. Histological diagnosis of the lesion was compatible with a diffuse large B cell lymphoma. He was started on methotrexate and rituximab; however, his clinical course kept deteriorating, and he died 64 days after his presentation. All prior cases of primary lymphoma of the chiasm are reviewed.

Long-term clinical course of immunotactoid glomerulopathy complicated with diffuse large B-cell lymphoma

2021 ◽  
Author(s):  
Haruka Takahashi ◽  
Takashi Sano ◽  
Sayumi Kawamura ◽  
Keiko Sano ◽  
Ryoma Miyasaka ◽  
...  
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Immunotactoid Glomerulopathy ◽  
Large B Cell

scholarly journals Prognostic significance of aberrant CD5 expression in B-cell leukemia

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Kaveh Jaseb ◽  
Daryush Purrahman ◽  
Saeid Shahrabi ◽  
Majid Ghanavat ◽  
Hadi Rezaeean ◽  
...  
Keyword(s):  
B Cell ◽  
English Language ◽  
Clinical Course ◽  
Relevant Literature ◽  
Prognostic Significance ◽  
Cell Leukemia ◽  
B Cell Malignancies ◽  
Aberrant Expression ◽  
B Cell Leukemia ◽  
Prognostic Importance

Aberrant expression of CD5 (as a T-cell marker) is seen in some leukemia and lymphoma of B lineage origin. Given that the signaling resulting from the expression of this marker plays an essential role in the development of leukemia and lymphoma, evaluating the expression of this marker is of paramount importance. Therefore, our goal in this study was to investigate the prognostic importance of CD5 expression in B-cell leukemia and lymphoma. We evaluate CD5 expression in normal and leukemic B-cells by identifying relevant literature through a PubMed search (1998-2018) of English language papers using the terms: ‘CD5,’ ‘B-cell,’ ‘Leukemia,’ and ‘Lymphoma.’ We are doing this thorough comparison of results from CD5 positive and negative cases to make a correct decision about prognostic importance of CD5 expression in these malignancies. In a number of B-cell malignancies, CD5 is expressed in varying degrees. Due to the different origins and characteristics of these malignancies, the results of CD5 expression evaluations are heterogeneous and impossible to generalize. However, CD5 expression is sometimes associated with clinicopathologic findings, more invasive clinical course, and even resistance to treatment (specifically in DLBCL) among CD5- positive patients, which appears to be a function of CD5 signaling and its downstream factors such as STAT3. Depending on the type of malignancy, CD5 expression is associated with good or bad prognosis, which can be used as an auxiliary prognostic factor to assess the clinical course of B-cell malignancies. Moreover, the difference in expression levels of CD5 in a variety of B-cell malignancies allows for differential diagnosis of these malignancies, which can be helpful when diagnosis is difficult.

Non-invasive B-cell clonality markers may help in the rational approach to HCV SVR cryoglobulinemic patients with persisting manifestations

2018 ◽  
Vol 50 (3) ◽  
pp. e356
Author(s):  
S. Lorini ◽  
L. Gragnani ◽  
V. Santarlasci ◽  
M. Monti ◽  
U. Basile ◽  
...  
Keyword(s):  
B Cell ◽  
Rational Approach ◽  
Non Invasive ◽  
Cell Clonality

The Relevance of VDJ PCR Protocols in Detecting B-Cell Clonal Expansion in Lymphomas and Other Lymphoproliferative Disorders

1995 ◽  
Vol 81 (6) ◽  
pp. 405-409 ◽  
Author(s):  
Valli De Re ◽  
Salvatore De Vita ◽  
Antonino Carbone ◽  
Gianfranco Ferraccioli ◽  
Annunziata Gloghini ◽  
...  
Keyword(s):  
B Cell ◽  
Wide Spectrum ◽  
Clonal Expansion ◽  
Lymphoproliferative Disorders ◽  
Region Gene ◽  
B Cell Malignancy ◽  
Polymerase Chain ◽  
Hodgkin's Lymphomas ◽  
Cell Clonality ◽  
Cell Clonal Expansion

Aims and background The detection of immunoglobulin heavy chain variable (VH)-diversity (DH)-joining (JH) region gene rearrangement by polymerase chain reaction (VDJ PCR) has been recently proposed as a rapid approach to assess B-cell clonality in lymphoproliferative disorders. The aim of the present study was to determine the efficacy of VDJ PCR in a wide spectrum of lymphoproliferative disorders previously characterized by immunohistochemistry and Southern blot (SB). Methods 83 SB-rearranged B-cell non-Hodgkin's lymphomas (NHL) of different histotype, 22 cases of SB-unrearranged classical Hodgkin's disease (HD), 18 cases of HIV-related reactive lymphadenopathy, and 4 frankly pre-lymphomatous lesions (MESA) in the course of Sjögren's syndrome were investigated by 2 different VDJ PCR protocols (FR3, FR2). Results The detection rate in NHL was 64% and 71% using the protocols FR3 and FR2, respectively. However, the overall VDJ PCR efficacy increased to 81% by combining the results of both protocols. In addition, differences in the combined, as well as in the single FR3 or FR2 protocol efficacy, were noted in the different NHL subgroups. B-cell clonality was also detected in 4/22 (18%) SB-unrearranged classical HD cases and in 2/18 (11%) reactive lymphadenopathy cases, whereas it was demonstrated in all the MESA lesions, 2 of them being SB-negative. Conclusions VDJ PCR represents a useful and rapid technique to detect B-cell clonality in NHL, although with some differences depending on the NHL histotype and the panel of primers employed. The technique may also be of value to investigate the possible progression of early B-cell clonal expansion into frankly B-cell malignancy and to contribute to the controversy about the clonal lineage origin of the putative HD malignant cells.

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